Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

HPV Vaccine May Help Women With Cervical Conditions

Published: Thursday, March 29, 2012
Last Updated: Thursday, March 29, 2012
Bookmark and Share
Healthcare article reports how study suggests immunization can reduce their risk for cervical disease later on.

A new study finds that women diagnosed with pre-cancerous cervical conditions after they get the human papillomavirus (HPV) vaccine can still benefit from the shot because it cuts their risk of future HPV-related cervical disease.

"This study helps to clarify the effects of the HPV vaccine and further define its use," noted one expert, Dr. Elizabeth Poynor, a gynecologic oncologist and pelvic surgeon at Lenox Hill Hospital in New York City.

Poynor, who was not involved in the new research, said it "is the first to address the effect of the HPV vaccine in women who have undergone treatment for HPV-related disease."
The study was published online March 27 in the BMJ.

HPV remains the most common sexually transmitted infection in the United States and can cause health problems ranging from genital warts to cervical cancer, according to the U.S. Centers for Disease Control and Prevention. HPV infection is thought to be the leading cause of cervical cancer, and two HPV vaccines, Gardasil and Cervarix, have received U.S. Food and Drug Administration approval.

Previous research has shown that HPV vaccination does not prevent progression to cervical pre-cancers in women who have an HPV infection when they receive the vaccine.

However, this is the first study to examine if HPV vaccination can prevent future cervical disease in these women after they've been successfully treated for their current condition, the researchers pointed out in a journal news release.

The study involved an international team of researchers led by Dr. Elmar Joura of the Medical University of Vienna. The investigators analyzed data from 1,350 young women in 24 developed and developing countries who took part in two clinical trials in which they received either the HPV vaccine or an inactive placebo. The women were subsequently diagnosed with either a vulvar or vaginal disease (including genital warts) or had required cervical surgery.

Among women who required cervical surgery after taking part in the studies, the risk of getting a subsequent HPV-related disease was 6.6 cases per 100 women per year among those who received the HPV vaccine and 12.2 cases per 100 women per year among those who received the placebo. This translates into more than a 46 percent reduced risk for women who received the HPV vaccine, the authors noted.

The researchers also found that the risk of pre-cancerous changes of the cervix and other "high-grade" cervical disease was almost 65 percent lower in those who received the HPV vaccination than in those who received the placebo.

Among women who were diagnosed with and treated for vaginal or vulvar disease, the risk of any future HPV-related disease was about 35 percent lower among those who received the HPV vaccine than among those who received the placebo, the study authors reported.

Two other experts said the findings appear heartening.

"While questions remain on the design of the study, it offers another reassurance that the efficacy of the quadrivalent HPV vaccine as initial protection may extend to decreasing subsequent diseases after initial vaccination," said Dr. Linus Chuang, director of gynecologic oncology at Mount Sinai Medical Center in New York City.

And Dr. Stephanie Blank, director of the gynecologic oncology fellowship at NYU School of Medicine, agreed that the study "describes potential further benefits of the HPV vaccine. HPV causes cervical cancer but affects even more women by causing cervical dysplasia [abnormal cell growth]." She noted that "dysplasia, which itself is only dangerous due to its association with cancer, results in multiple procedures, extensive health care costs and patient angst."


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
Experimental MERS Vaccine Shows Promise in Animal Studies
A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines.
Sweet Revenge Against Superbugs
A special type of synthetic sugar could be the latest weapon in the fight against superbugs.
Researchers Develop Vaccine that Protects Primates Against Ebola
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola.
Universal Flu Vaccine in the Works
A new study has demonstrated a potential strategy for developing a flu vaccine with potent, broad protection.
Immunotherapy Shows Promise for Myeloma
A strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Ferring Bets on Bacteriophages to Treat Inflammatory Bowel Disease
Ferring Pharmaceuticals have annoucned that it will collaborate with Intralytix in the latest phase of its early stage development programme for a bacteriophage-based therapy for inflammatory bowel disease (IBD).
A Novel Drug to FIght Malaria
An international team of scientists has announced that a new compound to fight malaria is ready for human trials.
Ebola Vaccine Trial Begins in Senegal
A clinical trial to evaluate an Ebola vaccine has begun in Dakar, Senegal, after initial research started at the Jenner Institute, Oxford University.
New Cell Structure Finding Might Lead to Novel Cancer Therapies
University of Warwick scientists in the U.K. say they have discovered a cell structure which could help researchers understand why some cancers develop.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!