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Scientific News
Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression
The transcription factors that control YAP gene expression are unknown. This study demonstrates that ß-catenin/TCF4 complexes bind a DNA enhancer element within the first intron of the YAP gene to drive YAP expression in CRC cells.
Cholinesterases, a Target of Pharmacology and Toxicology
This review’s main focus is on cholinesterases as targets of toxins and drugs. The biochemistry of AChE and BuChE is also discussed. Drugs and toxins are divided in chapters according to target sites.
Launch of DIRECT - An Innovative Medicines Initiative Project for Personalized Medicine in Diabetes
Academia and the pharmaceutical industry working together in the fight against diabetes.
Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expression
The lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.
Biodegradable Nanoparticles of mPEG-PLGA-PLL Triblock Copolymers as Novel Non-Viral Vectors for Improving siRNA Delivery and Gene Silencing
The gene silencing efficiency of mPEG-PLGA-PLL NPs is shown to be higher than that of commercially available transfecting agent Lipofectamine, while showing no cytotoxicity. The purpose of this work was to synthesize the novel biodegradable mPEG-PLGA-PLL NPs encapsulating siRNA, and examine the physical properties of NPs and in vitro siRNA release profile from NPs.
Study on Pivot-Point Vibration of Molecular Bond-Rupture Events by Quartz Crystal Microbalance for Biomedical Diagnostics
Molecular bond-rupture scanning is an effective method for the measurement of the energy level necessary to break a bond and distinguishing specific and nonspecific binding of biological molecules.
FDA Approves Gen-Probe's PROGENSA® PCA3 Assay
Company reveals first molecular test to help determine the need for repeat prostate biopsies in men who have had a previous negative biopsy.
An ice age flower 30,000 year old revived - resurrection of seed from permafrost
It was an Ice Age squirrel's treasure chamber, a burrow containing fruit and seeds that had been stuck in the Siberian permafrost for over 30,000 years. From the fruit tissues, a team of Russian scientists managed to resurrect an entire plant in a pioneering experiment that paves the way for the revival of other species.
NIH Common Fund Researchers Uncover Structure of Important Target for Drug Design
Researchers have uncovered a potent class of small molecules that selectively turn on the S1P1 receptor.
Two Decades of Studying Non-Covalent Biomolecular Assemblies by Means of Electrospray Ionization Mass Spectrometry
MS has evolved to impact a wide range of applications in structural biology. This paper charts some of the milestones in MS development as they pertain to the study of non-covalent complexes, and the novel applications they have enabled.
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It's Official...LABVANTAGE 6 Has Been Released!
24 Jan 2012

Video Blog by Dave Ciabattoni and Jeff Vannest of LABVANTAGE Solutions, Inc.

Dave Ciabattoni, Senior Director of Software Development, and Jeff Vannest, Director of Strategic Solutions, discuss the recent release of LABVANTAGE 6.

LABVANTAGE 6, which was released on Monday, January 16th, was an intensive, 18-month project. Jeff and Dave touch upon many topics, including how the developers worked closely with customers, the three leading industry application servers and opportunities for SQL*LIMS customers. The video below explains much more on these and other important topics.

The video can be viewed here 

About LABVANTAGE

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ, with offices around the world. We offer a comprehensive portfolio of products and solutions for the laboratory, including Laboratory Information Management Solutions (LIMS), quality electronic laboratory notebook (ELN) and business intelligence. www.labvantage.com.

Posted By: KRAT7270 Comments
 

JBoss Application Administration Training
24 Jan 2012

Written by Jeff Zollars of LABVANTAGE Solutions, Inc. 

I had the opportunity to attend a Red Hat training class on JBoss Application Administration in the LABVANTAGE training center located in Somerset, NJ. Before this class, I’d only worked with the Oracle Application Server 10g. I was quite impressed with the capabilities of the JBoss Application server.

First, I want to mention that the LABVANTAGE training center is wonderful. The classroom is configured well for PC training classes, well-stocked with snacks, drinks and coffee, therefore creating a very inviting learning environment. I appreciated the one cup at a time coffee maker, those of you who know me know that I am a “coffee achiever” and run on a high-grade dark roast coffee. This requirement was well satisfied the whole week. The desks and computers were comfortable to work on as there was plenty of room for both the keyboard and manual on the desk, which can easily make many PC training classes awkward.

JBoss is an open-source Java EE-based application server from Red Hat. JBoss implements the full Java EE part of Java. Also, because it is Java-based, the JBoss application server operates cross-platform, running on any OS that supports Java. I was quite impressed with the capabilities of JBoss and how easy it is to install and configure. The install is essentially to unzip the distribution onto the server. I also found it quite easy to deploy applications. In addition, once installed and configured it is also simple to backup and restore.

Unlike other application servers, JBoss is not an integrated environment. There is no development environment, JVM or database built into the application server. Instead, each of these can be supplied by your in-house standard installations or a preferred vendor.

The current JBoss application server is fully featured, and supports SSL, LDAP and clustering. The app server has a new GUI, called JConsole, that displays the application server processes and work in progress.

The class exercises were quite complete and provided a chance to work with all the major features discussed in the class. These included the installation of the Java JVM, the JBoss application server, configuring and connecting via LDAP, setting up encrypted passwords, SSL and configuring clustering to name a few.

While I do not feel like a fully seasoned JBoss administrator just yet, I do feel like I have a solid foundation to install, configure and deploy applications in a JBoss application server. I also whole-heartedly recommend installing applications on this robust app server.

About LABVANTAGE

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ, with offices around the world. We offer a comprehensive portfolio of products and solutions for the laboratory, including Laboratory Information Management Solutions (LIMS), quality electronic laboratory notebook (ELN) and business intelligence. www.labvantage.com.

Posted By: KRAT7270 Comments
 

An Instrument Interfacing Business Case: Interview with Hera Group
24 Jan 2012

Written by Sergio Nasi of LABVANTAGE Solutions, Inc.

Yet, effective and streamlined interfaces between a LIMS system and analytical instruments can have a great and positive impact on the productivity and profitability of the laboratory.

We discuss this topic with Daniele Nasci, Head of the analytical laboratory of Sasso Marconi (Bologna, Italy) of Hera Group, one of the biggest Italian, multi-utility companies which provides environmental, water and energy services. Hera Group was created in 2002 from the merger of eleven public utilities companies operating in Regione Emilia Romagna. They are publicly traded on the Italian stock exchange, have a workforce of almost 7,000 employees and have impressive revenues, which exceeded 3.7 billion euros in 2010.

Q: Mr. Nasci, could you please give us a short history of the evolution of the laboratory within the Hera Group?

DN: Since the inception of the holding, the laboratory  has always been an important part of our enterprise business processes and over the years it has become a paramount business unit, playing a critical role in the control of the quality of the services provided by Hera to its customers.

Q: How many laboratory units belong to your organization and what geographical area do they cover?

DN: There are three lab units, specialized by analytical matrix and localized in the following sites:

  • Sasso Marconi (Bologna) for water and microbiology analyses
  • Forlì for solid waste, micro-pollutants and atmosphere emissions
  • Ravenna for hazardous liquid waste

The collected samples come from an area covering more than 60% of Regione Emilia Romagna and in particular the districts of Bologna, Modena, Ferrara ,Bologna, Forlì, Cesena and Rimini.

Q: For how many years have you been using a LIMS system and what are the most important benefits?

DN: We adopted a LIMS system back in 1991 when we launched the initial implementation on SQL*LIMS version 4.0.16, subsequently upgraded to newer versions, a milestone achievement which drastically boosted laboratory productivity and produced countless benefits. To name a few: a dramatic increase in speed and accuracy of the electronic processing, management and archiving of data, ease of access by our customers to the information stored in the system. Our LIMS is centralized, it serves the three laboratories and our clients can review analytical results in real-time, be notified via email in case of out-of-specs, generate and print analysis reports, etc.

Q: What were the main factors which drove the adoption of interfaces between LIMS and laboratory instruments?

DN: In the Sasso Marconi laboratory alone, we perform about 500,000 analytical tests per year. Prior to establishing the connectivity between LIMS and the instrumentation and automating the data collection procedures, 2 FTEs were assigned to manual result entry. With the adoption of instrument interfacing we were able to re-assign this staff to more productive tasks, almost eliminate the errors in the transcription of results from the instrument to the LIMS and greatly reduce the task turn-around and time. We could then deliver analytical results to our customers faster and more reliably, reduce the re-analysis rate, abate the number of complaints and increase the overall quality of our services.

Q: What are the types of instruments currently interfaced?

DN: We connected the most commonly used analytical methods such as Inductively Coupled Plasma (ICP), Gas Chromatography and Mass Spectrometry (GC-MS), Total Organic Carbon (TOC).

Q: In light of your experience ,what do you think future developments might be?

DN: We aim to implement fully bi-directional protocols in that complete worklists (including the list of samples to be analyzed and the required analytical parameters) can be transmitted to the instrument, sparing the operator from the hassle of manually specifying on the instrument’s computer the list of submitted samples and the wanted analytical determinations.

Q: Where do you see margins for improvement and how do you think LABVANTAGE can help you?

DN: I’m seeing a clear trend towards the adoption of fully computerized procedures and progressive elimination of paperwork. This trend, which is proceeding at a fast pace in other industries such as pharmaceuticals, is now gaining momentum in laboratory units of utility companies like ours. We are therefore considering with great interest the electronic laboratory notebook solution (ELN) offered by LABVANTAGE.

About LABVANTAGE

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ, with offices around the world. We offer a comprehensive portfolio of products and solutions for the laboratory, including Laboratory Information Management Solutions (LIMS), quality electronic laboratory notebook (ELN) and business intelligence. www.labvantage.com.

Posted By: KRAT7270 Comments
 

ESBB Inaugural Conference 2011
23 Jan 2012

Written by Andrew Miles of LABVANTAGE Solutions, Inc.

Matt Rogers and I were very proud to attend the first annual meeting of ESBB (European, Middle Eastern & African Society for Biopreservation and Biobanking) held in Marseille, France from November 16th to 19th 2011. LABVANTAGE has supported this European chapter of ISBER since its inception in 2010 and is delighted to have 2 representatives on the ESBB Vendor Committee.

The organizing committee couldn’t have chosen a better venue to host this inaugural meeting. It opened in warm autumn sunshine and clear blue skies at the Pullman Palm Beach Hotel, off the shores of the Mediterranean. I have known the ESBB President, Pasquale De Blasio, for two years now, through our work with Biorep in Italy. It was great to meet him again as he personally welcomed us to the conference.

Approximately 350 delegates, from all around the world, registered for the event and enjoyed a challenging and varied agenda of lectures and presentations following the conference theme of “Identifying the challenges and opportunities for biorepositories today and in the next 5 years.” Focused sessions highlighting ethical issues, funding, biobank networks, and novel technologies, amongst other subjects, were well attended and generated much interest and lively debate amongst the audience. Having the opportunity to attend some of the lectures in person is a valuable opportunity to broaden and update our domain knowledge within the company, therefore allowing us to provide better solutions for our customers. An informal evening reception provided the ideal opportunity for delegates to catch up with old friends and colleagues and relax over a glass (or two) of wine. Matt and I took the opportunity to enjoy a leisurely dinner with one of our partners from France who was attending the meeting.

LIMS & BI by LABVANTAGE | Andy Miles ESBB 2011An extensive exhibition area was open to delegates throughout the 3 days of the conference, 36 vendors and sponsors representing a broad range of hardware and software solutions from across the Biobanking sector were present. LABVANTAGE was delighted to welcome both new prospects and existing customers to its exhibition stand during the event. As always, there was a significant amount of interest in our market-leading Bio-Bank solution. An existing customer came over to say hello and mentioned a couple of issues that needed attention. A short discussion and a phone call later, the issues were resolved. You never know what will come up during these meetings, but we are always happy to help.

For more information on ESBB and to view the full conference agenda visit www.esbb.org.

About LABVANTAGE

LABVANTAGE Solutions, Inc. is headquartered in Somerset, NJ, with offices around the world. We offer a comprehensive portfolio of products and solutions for the laboratory, including Laboratory Information Management Solutions (LIMS), quality electronic laboratory notebook (ELN) and business intelligence. www.labvantage.com.

Posted By: KRAT7270 Comments
 
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