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Friday, August 22, 2014
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Best Quality Insulin for Cell Culture

Webcasts
A Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial ResultsA Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial Results
Qasim Rafiq, Loughbrough University, speaking at Advances in Cellular Assays & Cell Culture 2014
Diagnosis and Prevention of Cell Line Cross Contamination; Causes, Identification and PreventionDiagnosis and Prevention of Cell Line Cross Contamination; Causes, Identification and Prevention
John Masters, University College London, speaking at Advances in Cellular & Cell Culture 2014

Market Reports
Biologics
RI Technologies

This report on Biologics gives a market insight into products types including Monoclonal Antibodies, Blood & Blood Products, Vaccines, Insulin and Other, for both human and animal consumption.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
3D Cell Culture Trends 2013
HTStec

This market report summarizes the results of HTStec’s 3rd industry-wide global web-based benchmarking survey on three dimensional (3D) cell culture technologies carried out in July 2013.
Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities
Global Data

The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.
Cell Migration Assays Trends
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on cell migration, motility or invasion assays carried out in July 2012.
Scientific News
Assessing Anticancer Drugs Efficacy by Amino Acid Metabolomics
Researchers aimed to develop a method that determines the therapeutic efficacy of anticancer drugs based on the changes in amino acid metabolism at the cellular level.
Apple Derived Cellulose Scaffolds for 3D Mammalian Cell Culture
Researchers demonstrate that cellulose scaffolds are a potentially useful biomaterial that can be successfully employed for in vitro 3D cell culture.
Advanced Cell Culture Techniques for Cancer Drug Discovery
This review focuses on the culturing of cell lines representative of solid cancers in advanced cell culture conditions.
Silicon Substrate as a Novel Cell Culture Device for Myoblast Cells
Researchers describe the use of a commercially available monocrystaline silicon PV device to be used as substrate for culturing of C2C12 mammalian cells.
Ptychographic Microscope for Three-Dimensional Imaging
3D ptychographic method used to visualize 3D specimens up to 34 tomographic sections in depth.
3D Cell Culture System to Study Tumour-Stroma Interactions
The model allows investigation of tumour-stroma interactions, addressing the importance of having a more in vivo like cell culture model.
What Fuels Salmonella’s Invasion Strategy?
As well as reducing the effects Salmonella can have we also need more effective ways to combat it once it's inside our bodies.
InSphero Publishes 3D Tumor-Stroma Model for Non-Small Cell Lung Cancer
PLOS One article delivers promising co-culture method to mimic tumor microenvironment, demonstrating potential for biomarker and drug discovery.
How a Silly Putty Ingredient Could Advance Stem Cell Therapies
The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become.
AMSBIO Publishes Comprehensive Cell Culture Handbook
Extensive 48-page handbook is intended for research scientists looking to culture cells in more physiologically relevant environments.
Business News
Fujifilm Diosynth Biotechnologies Expands Cell Culture Manufacturing Capacity
The company expands capabilities with the addition of two new 2,000l single-use bioreactors.
Miltenyi Biotec Acquires Gene Therapy Assets from Lentigen Corporation
Addition of lentiviral gene delivery capabilities complements strategic partnering portfolio.
Reprocell Acquires Reinnervate and BioServe
The company group now offers products and services that spans 2D and 3D cell culture, stem cell culture media, iPSC-derived cells and human tissue samples.
International Bioprinting Congress
Select Biosciences South East Asia is pleased to report on the success of the inaugural International Bioprinting Congress, which took place at the Biopolis, Singapore on the 24-25 July 2014.
ELRIG Announces Drug Discovery 2014 Programme and Pre-Conference SLAS Short Courses
Now in its 8th year, the conference and exhibition is the largest drug discovery meeting in the UK, and is expected to attract over 1000 delegates.
Horizon and OPDC Sign Collaboration Agreement
Horizon CombinatoRx to perform in-vitro cell line screening of OPDC clinical stage development candidates.
Bruker Awarded Fourth PeakForce Tapping Patent
AFM mode uniquely combines highest resolution imaging and material property mapping.
Promega to Break Ground for New Processing and Manufacturing Facility
Facility will allow for efficiency improvements for processing, packaging, staging and shipping products.
SLAS Short Courses at ELRIG Drug Discovery 2014
SLAS short courses will focus on high content screening, cell-based assays and 3D culture models, and laboratory automation.
Rentschler Invests EUR 24 Million in Stainless Steel Bioreactor Manufacturing
The Twin system should be operational in early 2017.

Events
Enabling Genomic Technologies
11 Sep 2014
Enabling Genomic Technologies ...
More Information
Advances in Stem Cell Research
16 Sep 2014
Advances in Stem Cell Research ...
More Information
3rd Annual BioPharma Asia Cong
25 Sep 2014
3rd Annual BioPharma Asia Cong ...
More Information
2nd Annual Cell Culture Asia C
25 Sep 2014
2nd Annual Cell Culture Asia C ...
More Information

ePosters
The Effects of Dimethylphthalate on the Viability and Development of Drosophila melanogaster
Wagner College

My research studies the effect of dimethylphthalate (DMP), a putative endocrine disruptor, on the viability and development of the model organism Drosophila melanogaster.
Targeted cancer therapy based on blocking the expression of genes and small doses of oxaliplatin.
Centre for Medical Genetics Russian Academy of Medical Sciences, Koltsov Institute of Developmental Biology Russian Academy of Sciences

The major drawbacks of the prescribed chemotherapy, are still remain the significant side effects and drug - resistance. Even targeted chemotherapy by means of specific antibodies do not always help to solve these complications. Our purpose was to identify potential biological targets associated with the development of drug resistance and to develop a specific method of suppressing the viability of cancer cells exposed to low doses of standard chemotherapy.
Comparison of Three Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development
ReachBio LLC

Objective: To identify an assay that can accurately predict the risk of CRS and CS associated with investigational biotherapeutics. A comparison of three methods were used: (a) immobilization of test antibody on plastic, (b) co-culture of PBMC's on HUVEC's and (c) pre-culture of PBMC's at high cell density.
Droplet Microfluidics for 3D Epithelial Cell Culture
CEA Grenoble

The challenge facing 3D cell culture today is to adapt current models to a systems biology approach - in particular, to enable RNA interference-based screens to study the effects of the microenvironment on cellular function.
Droplet Microfluidics for 3D Epithelial Cell Culture
CEA Grenoble – DSV/iRTSV/BGE/ BIOMICS, INSERM U1038 – UJF, Grenoble-France

The challenge facing 3D cell culture today is to adapt current models to a systems biology approach - in particular, to enable RNA interference-based screens to study the effects of the microenvironment on cellular function.
Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
TTP Labtech

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.
Does the increase of exosomal microRNAs reflect an activated immune system in melanoma?
Miltenyi Biotec GmbH

Cutaneous malignant melanoma is a form of skin cancer that accounts for 65% of skin cancer-related deaths. The incidence increases continuously, and while early detection leads to nearly 100% survival rates, the mortality raises to greater than 80% for patients with advanced disease.
A New Approach to Increase Yields and Improve Functionality of Recombinant Proteins
BioSilta Oy

The ability to express and extract fully functional proteins in sufficient quantities from bacterial cultures is a prerequisite for many projects in which recombinant proteins are required for structural studies, functional characterization, as assay components or for other applications. However, low yield, poor solubility and lack of functionality are often associated with, what should be, a routine procedure.
A Novel Synthetic Peptide as a Tool for Microvesicles / Exosomes isolation ©
New England Peptide, Inc

We have engineered and validated a synthetic peptide (Vn96*) with specific affinity for canonical heat shock proteins (HSPs) as a tool for rapid isolation of Exosomes or extracellular microvesicles (together referred to as eMVs here) from cell culture media, human and animal body-fluids.
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Chang Gung University

Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech
Application Notes
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
3D cell culture: a realistic and reproducible collagen-based environment
Tecan Group

Researchers are increasingly turning to 3D cell culture techniques, due to the improved physiological relevance of the cellular environment. 3D cell cultures offer a more in vivo-like response to stimuli more closely resembling the behavior of animal models or the human body.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Determination of microbial cell viability
Tecan Group Ltd.

The BacTiter-Glo Microbial Cell Viability Assay is a luminescence-based assay for the determination of the viability of microbial cells, using quantification of ATP as an indicator of metabolically active, viable cells. The assay protocol comprises the addition of the BacTiter-Glo reagent directly to the sample, and subsequent measurement of luminescence; cell washing, removal of culture medium, and multiple pipetting steps are not required.
Stem cell research: Creating blood for high throughput screening
Tecan Group Ltd.

Many different research fields, including investigation of early human development processes, disease research, drug discovery and cellular therapy applications, require appropriate in vitro models which can accurately mimic in vivo processes to provide biologically relevant results. Pluripotent stem cells (PSCs) offer a powerful system for creating in vitro models to address these questions.
Live Cell Biosensor Assay Used To Interrogate GPCRs - Comparative Analysis of Biosensor Variants
BioTek Instruments

This application note compares the performance of the highest and lowest affinity variants using automated methods and the highly-sensitive bottom reading capabilities of an HTS microplate reader. Sensitive detection of the 22F basal signal allows for use of this variant under a broad range of conditions, providing an assay with both superior dynamic range and sensitivity.
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
NanoSight Ltd

Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.
Automated Growth Monitoring of Microaerophilic Organisms
Tecan Group - Products

Walkaway growth monitoring of Helicobacter pylori in the Infinite® 200 PRO reader with Gas Control Module (GCM™).
Rapid Screening of a Cell-based Assay for GLP-1 Receptor Using a Natural Product Library
BioTek Instruments

Here we demonstrate the detection of GLP-1R binding through the incorporation of a homogeneous cell-based binding assay using HTRF Tag-lite® technology.
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