Corporate Banner
Satellite Banner
Cell Culture
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Stem Cells Develop Best in 3D

Published: Monday, November 26, 2012
Last Updated: Monday, November 26, 2012
Bookmark and Share
Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells.

In the long term this new knowledge can improve diabetes treatment with cell therapy. The results have just been published in the scientific journal Cell Reports.

Stem cells are responsible for tissue growth and tissue repair after injury. Therefore, the discovery that these vital cells grow better in a three-dimensional environment is important for the future treatment of disease with stem cell therapy.

"We can see that the quality of the cells produced two-dimensionally is not good enough. By putting the cells in a three-dimensional environment and giving them the proper growth conditions, we get much better results. Therefore we are developing a three-dimensional culture medium in gelatine in the laboratory to mimic the one inside an embryo," says Professor Anne Grapin-Botton from DanStem at the University of Copenhagen, who produced the results together with colleagues from Switzerland and Belgium.

The international research team hopes that the new knowledge about three-dimensional cell growth environments can make a significant contribution to the development of cell therapies for treating diabetes. In the long term this knowledge can also be used to develop stem cell treatments for chronic diseases in internal organs such as the liver or lungs. Like the pancreas, these organs are developed from stem cells in 3D.

From stem cells to specialised cells

The research team has investigated how the three-dimensional organisation of tissue in the early embryonic stage influences development from stem cells to more specialised cells.

"We can see that the pancreas looks like a beautiful little tree with branches. Stem cells along the branches need this structure to be able to create insulin-producing cells in the embryo. Our research suggests that in the laboratory beta cells can develop better from stem cells in 3D than if we try to get them to develop flat in a Petri dish," explains Professor Grapin-Botton.

"Attempts to develop functional beta cells in 2D have unfortunately most often resulted in poorly functioning cells. Our results from developing cells in 3D have yielded promising results and are therefore an important step on the way to developing cell therapies for treating diabetes."

The research is supported by the Novo Nordisk Foundation, Swiss National Research Foundation, and the National Institute of Health (NIH), USA.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Shape Of Tumor May Affect Whether Cells Can Metastasize
Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.
‘Mini-Brains’ to Study Zika
Novel tool expected to speed research on brain and drug development.
Cytokine Triggers Immune Response at Expense of Blood Renewal
Research highlights promise of Anti-IL-1 drugs to treat chronic inflammatory disease.
Micro Heart Muscle Created from Stem Cells
Researchers have designed a new way to create micro heart muscle from stem cells using a unique dog bone dish.
“Secret Sauce” for Personalized, Functional Insulin-producing Cells
Researchers uncover molecular switch to make effective sugar-responsive, insulin-releasing cells in a dish, offering hope for diabetes therapy.
Insights into Early Human Embryo Development
Researchers at Karolinska Institutet and the Ludwig Cancer Research in Stockholm have conducted a detailed molecular analysis of the embryo’s first week of development.
Boosting Gene Transfer Capabilities
A new and highly efficient method for gene transfer has been developed.
Liver-On-Chip Tracks Dynamics of Cellular Function
Hebrew University’s liver-on-chip platform is uniquely able to monitor metabolic changes indicating mitochondrial damage occurring at drug concentrations previously regarded as safe.
EU Project Aims to Cure Type 1 Diabetes
Researchers develop organoids from insulin-producing cells for transplantation.
Hope for Combating Muscular Dystrophy
Decoding a sugar molecule and identifying a mechanism linking it to MS could help in the development of therapy for the disease.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!