Merck Millipore have introduced the Clarisolve® depth filter for single-stage clarification of pretreated feed streams. The Clarisolve® depth filter is a novel clarification device with a gradient density structure specifically designed to the particle size distributions of pretreated feed streams.
Delivering improved volumetric capacity and reduced turbidity over any currently available depth filtration technologies, Clarisolve® depth filters process pretreated feeds in a significantly reduced footprint without the need for the secondary stage of clarification. The use of Clarisolve® depth filters eliminates the need for centrifugation which enables implementation of a fully single-use process train, and also considerably reduces the pre-use flushing requirements. This technology was developed to address the shortcomings of traditional downstream clarification approaches when processing high cell density and high-product titer cell cultures.
”Until now, higher titers coming from upstream bioreactors have posed a challenge to conventional approaches to clarification,” described Vin Donovan, Vice President of Biopharm Process Solutions, Merck Millipore. “With Clarisolve® depth filters, our customers can now take full advantage of high density pre-treated feed streams and improve overall process economics.
Clarisolve® filters are available from lab, to pilot, to process scale in the industry leading disposable Pod format.