Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cerilliant Offers New Certified Spiking Solutions®

Published: Thursday, November 29, 2012
Last Updated: Thursday, November 29, 2012
Bookmark and Share
Preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Cerilliant has introduced new Certified Spiking Solutions® of nicotine metabolites norcotinine and trans-3-hydroxycotinine as well as nicotine nitrosamines NNN, NNK, and NAB at concentrations of 1.0 mg/mL in methanol for each solution standard.

These certified reference solutions can be used as Snap-N-Spike® starting materials in the laboratory’s matrix of choice for preparation of calibrators and controls in nicotine testing and other clinical or diagnostic applications by LC/MS or GC/MS.

Nicotine biomarkers are commonly monitored in patients who smoke cigarettes, use other nicotine products such as nicotine gum and electronic cigarettes, or are exposed to environmental tobacco smoke.

Accurate patient results in clinical and diagnostic testing of nicotine use depend on accurate and consistent Certified Reference Materials for the numerous nicotine metabolites.

Neat material handling of nicotine analogs and their preparation as certified reference solutions offer significant challenges to the laboratory due to high toxicity of the neat materials and their sensitivity to air and light.

Cerilliant’s validated process includes manufacturing controls for sensitive compounds such as raw material handling and solution preparation under inert conditions and flame-sealing of ampoules under argon to minimize degradation and promote long-term shelf life.

Toxic materials are handled in isolation chambers and are gravimetrically prepared using precision balances which have been qualified to ensure minimal uncertainty.

“Protection of both production staff and the correct handling of these highly toxic neat materials are of paramount importance in the preparation of these solution standards. Consequently the formulation of the nicotine metabolites is limited to staff who have received and passed the appropriated level of internal training through our proficiency testing program to ensure proper use of equipment and accurate preparation using the glove boxes,” added Gregory Kirkovits, PhD, manager of the Standards & Packaging group.

Cerilliant’s latest nicotine metabolite and nitrosamine products complement their current offering of Certified Spiking Solutions® for nicotine, including anabasine, cotinine, and nornicotine and their internal standards, all offered at concentrations suitable for dilution to working levels in the laboratory’s matrix of choice.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
AACC 2016 Sees Clinical Chemistry Labs Drive Precision Medicine Offerings
Biomarker assays to enable precision medicine and risk assessment, mass spec-based tests designed for use in clinical labs large and small, and liquid biopsy technology captured the spotlight at the AACC annual meeting.
Diagnosing Bacterial Infections in Blood Samples
Researchers have diagnosed a bacterial infection from a blood sample in infants.
Neurodvelopmental Disorder Cause Linked to SON Gene
A genetic link has been discovered for a previously unxplained neurodevelopmental disorder.
World's Most In-Depth Study to Detect Alzheimer's Disease
A multisite team will see the most thorough and vigorous testing for Alzheimer's ever performed on volunteers.
Personalised Medicine: Dose by Design
Personalised medicine holds the promise of a new approach to healthcare, tailored exactly to our individual needs, as Congenica's Nick Lench discussed on a recent BBC Radio 4 programme.
Misdiagnosis in HCM Tests
Genetic tests for potentially fatal heart anomaly can misdiagnose condition in black Americans.
Computers Better Predict Lung Cancer Type, Severity
Study shows automating the analysis of cancer tissue samples increases the accuracy of tumor classification and patient prognoses.
Examining New Hypotheses for Undiagnosed Patients
UnDx Consortium gathers in San Diego to create new paths to identifying currently undiagnosed illnesses.
Automating Genetic Analysis
Researchers are looking to have computers help perform genetic analysis when scientists study a patient's genome to diagnose a disease.
Understanding Tumor Evolution
Study provides insight into tumor evolution; may point to improved diagnosis and treatment.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!