Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Dentistry School Receives $5M to Study Saliva Biomarkers

Published: Thursday, August 15, 2013
Last Updated: Thursday, August 15, 2013
Bookmark and Share
Imagine having a sample of your saliva taken at the dentist's office, and then learning within minutes whether your risk for stomach cancer is higher than normal.

The UCLA School of Dentistry received $5 million in funding from the National Institutes for Health to study biological markers in saliva to attempt to develop a tool for detecting stomach cancer. The study has the potential to create a new paradigm in the field of salivary diagnostics, and it could supply concrete evidence that saliva can be used in the detection of life-threatening diseases, including diabetes and cancers of the pancreas, breasts, ovaries and stomach.

The award comes from the NIH Common Fund, a program established to overcome obstacles in biomedical research that have hindered scientific discovery and its translation into improved human health. The funding awarded to the School of Dentistry comes from the Common Fund's Extracellular RNA Communication initiative, which has awarded leading research institutes around the world a total of $160 million to address the transformative potential of the emerging field of salivary diagnostics.

Leading UCLA's five-year project is Dr. David Wong, a pioneer in the field of salivary diagnostics, the dentistry school's associate dean of research, and the Felix and Mildred Yip Endowed Professor in Dentistry. His team will develop and definitively validate salivary extracellular ribonucleic acid (exRNA) biomarkers for stomach cancer detection.

Conventionally, RNA - which translates genetic code from DNA to make protein - was always believed to reside within cells. However, scientists have recently found that RNA is secreted into extracellular spaces, or spaces outside the cell. Researchers surmised that exRNA acts as an exocrine signal, a signal that travels by way of a duct, to alter the cell traits of target cells. This messaging system occurs in the body's central organs, such as the stomach and heart, and in the extremities, such as the fingers, toes and mouth.

With the Common Fund award, Wong's team will conduct a prospective study to develop a salivary biomarker panel that would definitively validate for stomach cancer detection. Their hope is to capture exRNAs in saliva samples secreted by stomach cancer cells to confirm whether the patient is at risk for stomach cancer.

"Salivary diagnostics is a very dynamic field with a lot of potential and I am excited that our research is advancing toward clinical maturation," Wong said. "The National Institutes for Health's support for developing salivary exRNA biomarkers as part of the Common Fund initiative is a strong statement that saliva is scientifically credible for the detection of systemic disease."

Wong's laboratory, along with collaborators, first discovered salivary exRNA molecules in 2004 and demonstrated their translational utility for detecting oral cancer. Over the next several years, the team developed salivary exRNA biomarkers for a number of oral and systemic diseases, including salivary gland tumors, Sjögren's syndrome and many life-threatening cancers. While there are other diagnostic constituents in saliva, salivary exRNAs are the most reliable markers for disease.

This NIH Common Fund initiative highlights the transformative potential of biological information revealed in exRNAs towards the regulation of health and diseases. Moreover, it echoes President Barrack Obama's Strategy for American Innovation to address the so-called Grand Challenges of the 21st century. High on the list of those challenges is the goal of "early detection of dozens of disease from a saliva sample."

"UCLA is uniquely poised to advance the basic, translational and clinical sciences of salivary diagnostics," said Dr. No-Hee Park, dean of the UCLA School of Dentistry. "A new landscape of saliva biology is on the horizon."

The research will be conducted in collaboration with Dr. Sung Kim, executive vice president and director of gastric cancer at the Samsung Medical Center in Seoul, Korea; Dr. David Chia, a professor in the department of pathology at the David Geffen School of Medicine at UCLA; Dr. David Elashoff, a professor in the department of biostatistics at the UCLA Fielding School of Public Health; and Dr. Yong Kim, an associate professor in the division of oral biology and medicine at the UCLA School of Dentistry.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Ultrafast DNA Diagnostics
New technology developed by UC Berkeley bioengineers promises to make a workhorse lab tool cheaper, more portable and many times faster by accelerating the heating and cooling of genetic samples with the switch of a light.
Monday, August 03, 2015
Genetic Markers for Detecting and Treating Ovarian Cancer
Custom bioinformatics algorithm identifies human mRNAs that distinguish ovarian cancer cells from normal cells and provide new therapeutic targets
Wednesday, May 27, 2015
May the Cellular Force be With You
Like tiny construction workers, cells sculpt embryonic tissues and organs in 3D space.
Friday, December 13, 2013
Chemical Signature for Fast Form of Parkinson's Found
The physical decline experienced by Parkinson's disease patients eventually leads to disability and a lower quality of life.
Monday, November 25, 2013
Discovery Could Lead to Saliva Test for Pancreatic Cancer
The disease is typically diagnosed through an invasive and complicated biopsy.
Tuesday, October 15, 2013
Cost-Effective Recommendations for Cancer Screening
When public health budgets are constrained, mammography screening should begin later and occur less frequently.
Tuesday, September 17, 2013
Sugar Helps Scientists Find and Assess Prostate Tumors
New GE technology enables UCSF researchers to safely detect tumors in real time.
Friday, August 23, 2013
Detailed look at Genetics of Human, Mouse Embryos
Scientists have used the powerful technology of single-cell RNA sequencing to track the genetic development of a human and a mouse embryo with unprecedented accuracy.
Wednesday, July 31, 2013
Major Changes Urged for Cancer Screening and Treatment
Scientific panel recommends new personalized strategies to reduce cancer overtreatment.
Tuesday, July 30, 2013
Brain Anomolies are Potential Biomarkers for Autism
Brain anomalies may serve as potential biomarkers for the early identification of the neurodevelopmental disorder.
Wednesday, July 10, 2013
App Helps Doctors, Students Learn to Diagnose Neurological Symptoms and Disease
The new app that presents a novel approach to learning the neurological physical exam, a challenging series of assessments aimed at diagnosing neurological disorders in patients.
Friday, May 17, 2013
Genetic Test Helps Predict Risk of Prostate Cancer Recurrence
Prostate cancer ranks as the most common internal malignancy diagnosed in men in the United States, but often does not require extensive treatment.
Friday, May 10, 2013
NIH Funds Study of Autism among African Americans
Five-year, $10 million grant to help continue research on the genetic causes of autism spectrum disorders and to expand investigations to include the genetics of autism in African Americans.
Tuesday, April 09, 2013
Brain-Imaging, Stroke Risk Test Identify Cognitive Decline
UCLA researchers have used a brain-imaging tool and stroke risk assessment to identify signs of cognitive decline early on in individuals who don't yet show symptoms of dementia.
Thursday, April 04, 2013
Prostate Cancer Now Detectable Using Imaging-Guided Biopsy
Groundbreaking research by a team of UCLA physicians and engineers demonstrates that prostate cancer can be diagnosed far more easily and accurately using a new image-guided, targeted biopsy procedure.
Thursday, December 13, 2012
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
'Fountain of Youth' Protein Points to Possible Human Health Benefit
Patients with higher blood levels of growth factor have lower risk of cardiovascular problems.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Imaging Software Could Speed Breast Cancer Diagnosis
Technology could improve access to diagnostic services in developing countries.
Data Mining DNA For Polycystic Ovary Syndrome Genes
A new Northwestern Medicine genome-wide association study of PCOS – the first of its kind to focus on women of European ancestry – has provided important new insights into the underlying biology of the disorder.
Algorithm Interprets Breathing Difficulties to Aid in Medical Care
Researchers from North Carolina State University have developed an efficient algorithm that can interpret the wheezing of patients with breathing difficulties to give medical providers information about what’s happening in the lungs.
Researchers Develop qPCR Prognosis Test for NSCLC Patients
A nine-gene molecular prognostic index (MPI) for patients with early-stage non-small cell lung cancer (NSCLC) was able to provide accurate survival stratification and could potentially inform the use of adjuvant therapy in patients struggling with the disease.
Genetic Test Could Improve Blood Cancer Treatment
Testing for genetic risk factors could improve treatment for myeloma – a cancer of the blood and bone marrow – by helping doctors identify patients at risk of developing more aggressive disease.
PTR-MS Breath Test Shows Potential for Detecting Liver Disease
Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!