Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Discover the Genetic Signature of Highly Aggressive Small Lung Tumors

Published: Thursday, October 03, 2013
Last Updated: Thursday, October 03, 2013
Bookmark and Share
A study conducted by the IDIBELL allows to identify this type of cancer at an early stage and adapt the treatment.

Lung cancer is currently the most lethal in the world. The main cause of these tumors is the tobacco and it is usually diagnosed in advanced stages when there are already few treatment options. There is a subgroup of tumors of the lung that thanks to diagnostic advances can be detected in early stages and in which the surgery can be more healing. These are the so-called small lung tumors.

However, one third of these tumours are highly aggressive and highly prone to generate metastases.

On September 30 the official journal of the American Society of medical oncology, the Journal of Clinical Oncology, publishes an article headed by Manel Esteller, Director of the Programme in Epigenetics and Biology of Cancer of the Biomedical  Research Institute of Bellvitge (IDIBELL), ICREA researcher and Professor of genetics of the University of Barcelona, that allows to identify these tiny but highly malignant lung tumours.

"The study is an international project funded by the European Union where we analyzed lung cancer in stage I, those tumours where surgery may be curative. We have found that one of every three small tumours will reappear and be associated with the death of the patient. But the most important thing is that we can already begin to identify which cancers will behave that way so aggressivly" explained Manel Esteller, director of the study.

"By analyzing DNA of these tumours we found that alterations in their genetic programme, the so-called epigenetic lesions, associated with their greater ease to grow and expand to the rest of the body. Specifically, they present changes in genes that turn them into undifferentiated tumours (homeobox genes) with a softer appearance (mesenchymal genes)

The finding represents not only the discovery of prognostic markers of the disease indicating how fast the tumour will progress, but also it may be useful for treatment. "If we know the small tumour is going to be very aggressive, better that we are not content with the simple surgical eradication of the same one and begin studying if we must add chemotherapy to treat these tumors of high risk” it concludes Manel Esteller.

In Europe are diagnosed each year more than 150,000 cases of lung cancer, 90% of them due to tobacco. Only between 10 and 15% survive five years after diagnosis.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Method Developed to Diagnose Hereditary Breast and Ovarian Cancer
Massive sequencing algorithm and bioinformatic analysis to detect very efficiently genetic mutations linked to the disease.
Wednesday, January 16, 2013
IDIBELL and ICFO Researchers Develop Technology that Predicts Metastasis in Breast Cancer
Raman is a promising microspectroscopy technique for identifying metastatic phenotype of breast cancer cells from their lipid profile.
Monday, October 22, 2012
Scientific News
"Gene Fusion" Drives Childhood Brain Cancers
Study co-led by Penn scientists highlights potential targets for future cancer therapies.
Head Injury Patients Develop Brain Clumps Associated with Alzheimer’s Disease
Scientists have revealed that protein clumps associated with Alzheimer's disease are also found in the brains of people who have had a head injury.
New Way to Identify Brain Tumor Aggressiveness
Looking at a brain tumor’s epigenetic signature may help guide therapy.
OncoCyte, The Wistar Institute Enter Global Licensing Agreement
Exclusive rights to commercialize biomarker assay follows years of positive collaboration on lung cancer diagnostic test.
Easier Diagnosis for Fungal Infection of the Lungs
A new clinical imaging method developed in collaboration with a University of Exeter academic may enable doctors to tackle one of the main killers of patients with weakened immune systems sooner and more effectively.
Antibiotic Susceptibility Testing
A team of biologists and biomedical researchers at UC San Diego has developed a new method to determine if bacteria are susceptible to antibiotics within a few hours, an advance that could slow the appearance of drug resistance and allow doctors to more rapidly identify the appropriate treatment for patients with life threatening bacterial infections.
Mitochondrial Troublemakers Unmasked in Lupus
Drivers of autoimmune disease inflammation discovered in the traps of pathogen-capturing white blood cells.
DNA Analysis in the Fast Lane
Rice bioengineers' method should lead to better database of thermal behaviors.
‘Simple Rules’ Calculate Ovarian Cancer Risk
Scientists have formulated a system that uses ultrasound images to accurately work out the likelihood of an ovarian growth being cancerous.
Finding the Needle in a Microbial Haystack
After developing a novel investigational technology called PathoChip that can rapidly identify elusive microorganisms, a team of Penn Medicine researchers recently succeeded for the first time in identifying a pathogen in a patient sample, demonstrating the proof of principle that this technology can be used to identify pathogens in human disease.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!