Corporate Banner
Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Metabolomics as a Diagnostic Tool in Gastroenterology

Published: Thursday, December 12, 2013
Last Updated: Thursday, December 12, 2013
Bookmark and Share
This review summarizes contributions that metabolomics has made in IBD and IBS and presents potential future directions within the field.

Abstract
Metabolomics has increasingly been applied in addition to other "omic" approaches in the study of the pathophysiology of different gastrointestinal diseases. Metabolites represent molecular readouts of the cell status reflecting a physiological phenotype. In addition, changes in metabolite concentrations induced by exogenous factors such as environmental and dietary factors which do not affect the genome, are taken into account. Metabolic reactions initiated by the host or gut microbiota can lead to "marker" metabolites present in different biological fluids that allow differentiation between health and disease. Several lines of evidence implicated the involvement of intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Also in irritable bowel syndrome (IBS), a role of an abnormal microbiota composition, so-called dysbiosis, is supported by experimental data. These compositional alterations could play a role in the aetiology of both diseases by altering the metabolic activities of the gut bacteria. Several studies have applied a metabolomic approach to identify these metabolite signatures. However, before translating a potential metabolite biomarker into clinical use, additional validation studies are required. 

The article is published online in the World Journal of Gastrointestinal Pharmacology and Therapeutics and is free to access. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Plasma Biomarkers for Breast Cancer Diagnosis
Plasma lipidomics profiling identified lipid biomarkers in distinguishing early-stage breast cancer from benign lesions.
Wednesday, May 11, 2016
Application of MALDI-TOF Mass Spectrometry in Clinical Virology
MS methods can be used currently for viral diagnosis but refinement of technology will be an important approach for the introduction of MALDI-TOF in routine viral diagnosis.
Monday, December 16, 2013
Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Rapid development of MS-based proteomic techniques in the last decade that has immensely helped researchers in candidate biomarker discovery.
Monday, May 13, 2013
Simple Filter Microchip for Rapid Separation of Plasma and Viruses from Whole Blood
Scientists have developed a disposable, pump-free, size exclusion–based filter microchip that can be used for plasma and virus separation from unprocessed whole blood samples in resource-constrained settings.
Wednesday, October 17, 2012
Molecular Beacons in Diagnostics
Molecular beacons specific for different target sequences and labeled with differently colored fluorophores can be used together to simultaneously identify and quantitate multiple targets in the same assay tube.
Monday, May 28, 2012
Serious Bacterial Infection Biomarkers Uncovered using Transcriptomic Analysis
Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.
Monday, May 14, 2012
DNA Methylation Analysis of Bone Marrow Cells at Diagnosis of Acute Lymphoblastic Leukemia and at Remission
The aim of this study was to identify genes that display aberrant DNA methylation independently of cytogenetic ALL subtype for further mechanistic studies of ALL.
Monday, April 16, 2012
Differential Diagnosis in Idiopathic Granulomatous Mastitis and Tuberculous Mastitis
The purpose of this study is to develop a new algorithm for the differential diagnosis and treatment of IGM and TM.
Monday, April 16, 2012
Applications of Aptasensors in Clinical Diagnostics
This review attempts to list examples of the research progress of aptamers in biosensor platforms that have been published in recent years.
Monday, April 02, 2012
Use of DNA Microarray Analysis in Diagnosis of Bacterial and Fungal Endophthalmitis
Microarray analysis is complementary to routine cultures for identifying causative microorganisms and is likely to be a useful tool in patients with suspected endophthalmitis who require rapid diagnosis and early antibiotic treatment.
Wednesday, March 21, 2012
Comparison of Real-Time Quantitative PCR and Culture for the Diagnosis of Emerging Rickettsioses
Isolation of Rickettsia species from skin biopsies may be replaced by PCR. In this stidy, scientists evaluated culture sensitivity compared to PCR based on sampling delay and previous antibiotic treatment.
Tuesday, March 20, 2012
Genetic Variation Screening of TNNT2 Gene in a Cohort of Patients with Hypertrophic and Dilated Cardiomyopathy
This study analyzed TNNT2 exons in patients with HCM and DCM diagnosis to improve diagnostic and genetic consultancy in affected families.
Monday, March 05, 2012
Sensing Movement: Microsensors for Body Motion Measurement
Motion sensing is a critical sensing modality that plays an important role in medical practice. In this paper, state-of-the-art microscale motion sensing technologies that can be utilized for human body motion determination will be introduced.
Monday, March 05, 2012
Study on Pivot-Point Vibration of Molecular Bond-Rupture Events by Quartz Crystal Microbalance for Biomedical Diagnostics
Molecular bond-rupture scanning is an effective method for the measurement of the energy level necessary to break a bond and distinguishing specific and nonspecific binding of biological molecules.
Wednesday, February 22, 2012
Practical Tools to Implement Massive Parallel Pyrosequencing of PCR Products in Next Generation Molecular Diagnostics
Scientists from Ghent University outline different PCR amplification based strategies for the screening of a multitude of genes in a patient cohort.
Monday, October 17, 2011
Scientific News
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Cancer Gene Predicts Treatment Response in Leukaemia
Study indicates the patients suffering from a lethal for of acute myeloid leukemia may live longer when receiving milder chemotherapy drugs.
New Diagnostic Tool for Familial Mediterranean Fever
A new tool developed by researchers at VIB and Ghent University could improve the process of diagnosing Familial Mediterranean Fever.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Molecular Signature for Aggressive Brain Tumor Uncovered
Researchers have identified genetic mutations in a highly agressive brain cancer that distinguishes the agressive, from the benign forms of the cancer.
Malaria Parasite Evades Rapid Test Detection in Children
A study at the University of North Carolina found that gene deletion poses a threat to Malaria eradication efforts.
Novel Urine Test to Predict High-Risk Cervical Cancer
Preliminary studies affirm accuracy and potential cost savings to screen for virus-caused malignancy.
GFC Diagnostics Wins Longitude Prize Discovery Award
The global award was won for the development of a cheap, quick and simple MRSA Test.
Understanding Circulating Tumour Cells
Research team develops new tool to track traveling cancer cells in the bloodstream.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!