Satellite Banner
Molecular & Clinical Diagnostics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

VolitionRx’s NuQ® Assays Demonstrate 80% Detection Rate in Prostate Cancer

Published: Monday, March 17, 2014
Last Updated: Monday, March 17, 2014
Bookmark and Share
Study data also demonstrates ability to distinguish between prostate and colorectal cancer.

VolitionRx Limited announces data from a pilot study into the utility of VolitionRx’s NuQ® tests to diagnose prostate cancer. 

The results from the trial show that VolitionRx NuQ® assays were able to detect approximately 80 per cent of prostate cancer cases. Significantly, the trial showed that not only does the test have a high detection rate for prostate cancer, but it can differentiate between colorectal and prostate cancer. It does this by detecting the levels of epigenetically altered circulating nucleosomes in each sample, the structure of which Volition has found to be different in the two different types of cancer. For example, levels of circulating nucleosomes containing H3K9(Me)3 were elevated in colorectal cancer, but supressed in prostate cancer.  This indicates that NuQ® ELISA tests could be used to detect both prostate and colorectal cancers. 

Dr. Jake Micallef, Chief Scientific Officer at VolitionRx, will present a poster at The International Society of Oncology and Biomarkers Congress (ISOBM) in Barcelona, sharing results of the latest study into the effectiveness of NuQ® assays as an initial screening tool in detecting colorectal and now prostate cancer.  The poster abstract and a PDF of the poster is available on the VolitionRx website at: http://volitionrx.com/technologies-abstracts-papers-posters.html. 

“This is a very exciting outcome for us as we continue the development of our NuQ tests,” says Dr. Jake Micallef. “To have proof that with the right panel combination, NuQ tests can distinguish between different types of cancer as well as healthy samples, is just what we’ve been working towards. Detection of two major cancers with a blood test is a major milestone and a sound basis on which to investigate further cancers for panels of NuQ tests that detect and distinguish cancer diseases.”

NuQ® assays identify and measure circulating nucleosomes structures for the presence of epigenetic cancer signals within the blood. Results from another recent trial conducted demonstrated that the NuQ® assays were able to also detect more than 85 per cent of colorectal cancer cases with greater than 85 per cent specificity. The earlier study took samples from both healthy subjects and subjects recently diagnosed with colorectal cancer.      

Volition is carrying out several clinical trials on the effectiveness of the NuQ® assays as a cancer diagnostic tool: 

• A 4,800 patient retrospective study and an 11,000 patient prospective study into colorectal cancer at Hvidovre Hospital, University of Copenhagen, Denmark. 

• A 2,000 patient prospective study that involves patients with the 20 most prevalent cancers at University Hospital in Bonn, Germany.

• A 250 patient study into colorectal cancer at CHU-UCL Mont Godinne Hospital, Belgium. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

VolitionRx Invests in Laboratory Automation System
Automation will accelerate analysis of blood samples for expanded colorectal cancer screening trial.
Wednesday, August 13, 2014
VolitionRx Extends Agreement with University Hospital Bonn to Include CE Mark Performance Evaluation
The agreement also doubles the Hospital’s prospective trial of 20 cancers, and adds a range of additional vital background work.
Thursday, April 24, 2014
VolitionRx Announces Collaboration with Wales Cancer Bank
VolitionRx Limited announces that it will commence a large internal clinical study for its Nucleosomics® diagnostic products this month.
Thursday, January 10, 2013
Scientific News
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Cancer Gene Predicts Treatment Response in Leukaemia
Study indicates the patients suffering from a lethal for of acute myeloid leukemia may live longer when receiving milder chemotherapy drugs.
New Diagnostic Tool for Familial Mediterranean Fever
A new tool developed by researchers at VIB and Ghent University could improve the process of diagnosing Familial Mediterranean Fever.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Molecular Signature for Aggressive Brain Tumor Uncovered
Researchers have identified genetic mutations in a highly agressive brain cancer that distinguishes the agressive, from the benign forms of the cancer.
Malaria Parasite Evades Rapid Test Detection in Children
A study at the University of North Carolina found that gene deletion poses a threat to Malaria eradication efforts.
Novel Urine Test to Predict High-Risk Cervical Cancer
Preliminary studies affirm accuracy and potential cost savings to screen for virus-caused malignancy.
GFC Diagnostics Wins Longitude Prize Discovery Award
The global award was won for the development of a cheap, quick and simple MRSA Test.
Understanding Circulating Tumour Cells
Research team develops new tool to track traveling cancer cells in the bloodstream.
Blood Glucose Monitoring Device for Diabetes
Novel breathalyzer offers alternative to finger stick testing for people with type 1 and 2 diabetes.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!