|Saliva’s Diagnostic Potential|
Advantages and disadvantages of using saliva as a diagnostic source of information.
|A Systematic Review of Lifestyle Modification in Adults with Non-Alcoholic Fatty Liver Disease|
C. Thoma, C. P. Day and M. I. Trenell, Newcastle University
This study reviews the causes of non-alcoholic fatty liver disease and the associated risk factor for type 2 diabetes and cardiovascular disease.
|Rapid PCR for Integration in Sample-to-answer Analysis Platforms|
S. Brunklaus, T.E. Hansen-Hagge, J. Erwes, J. Höth, M. Jung, D. Latta, X. Strobach, C. Winkler, T. Röser, M. Ritzi-Lehnert, K.S. Drese
This poster describes how molecular testing at the point-of-care can increase time to results and yield rather specific information, concentrating on PCR on a chip layout which proves to be fast and robust.
|Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray|
C. Zingaretti1, M. Arigò1, A. Cardaci1, A. Sinisi1, L. Muratori3, P. Colombatto4, F. Bonino2, P. Invernizzi5, , A.L. Zignego6 MC. Crosti1, M. Moro1, J. Geginat1, Pagani M.1, R. De Francesco1, S. Abrignani1. & M. Bombaci1
The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
|MicroRNA expression in normal and malignant prostate tissues|
In this study the aim was to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Nine miRNAs were found to be differentially expressed and they could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature, showing an accuracy of 85%.
|Point-of-Care Diagnostics for Sexually Transmitted Infections|
Pascal Craw, Wamadeva Balachandran
This poster introduces the recently enlarged DoCLab research group at Brunel University, London. This large multidisciplinary group brings together electronic, mechanical and computer engineers with molecular biologists, biochemists and clinical collaborators to develop fully integrated, multiplex Point-Of-Care-Tests (POCT) for the self- diagnosis of infectious diseases.
|Optical Microchip Sensors for Multiplexed Detection of Biological Pathogens|
D. Bhatta, A. Michel, M. Marti Villalba, G. D. Emmerson, I. J. G Sparrow, M. B. McDonnell, E. A. Perkins , R. W. Ely and G. A. Cartwright
SpectroSens, a multi-channel optical microchip sensor system suitable for rapid, label-free multiplexed detection of a wide range of bio-hazardous agents is presented. Optical chips containing multiple high-precision planar Bragg gratings are exploited as low-cost, robust refractive index sensors.
|SuNS microarray as novel biosensor for clinical diagnostics.|
Pisanelli B., Dattilo D., Chetta M., Carducci F., De Ceglia G.
We here present an innovative microarray platform which aims to produce an higher standard of clinical microarray technology. The fabrication approach, involving a novel printing technology (Supramolecular Nano-Stamping) to reduce the production costs of the chips, together with a peculiar probe design, aiming to improve the assay sensitivity and workflow, intend to make the SuNS microarrays well poised to become an important element in the clinical diagnostics market.
|Bi-functional Magnetic Microcarriers for Point-of-Care Diagnostics|
J.J. Palfreyman, D.M. Love, A.J. Philpott, K. Vyas, T. Mitrelias, C.H.W. Barnes
A novel type of microcarrier is presented, where a re-writable magnetic barcode is used to carry information. This technology has several advantages over the optical-based alternatives, whilst benefiting from the high-throughput of a microfluidic tool. Here, we present two different surface chemistries used to attach a probe and a control strand of DNA to an individual microcarrier. This is demonstrated with red and green fluorophores, clearly seen on either side.
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