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Optical Microchip Sensors for Multiplexed Detection of Biological Pathogens
D. Bhatta, A. Michel, M. Marti Villalba, G. D. Emmerson, I. J. G Sparrow, M. B. McDonnell, E. A. Perkins , R. W. Ely and G. A. Cartwright

SpectroSens, a multi-channel optical microchip sensor system suitable for rapid, label-free multiplexed detection of a wide range of bio-hazardous agents is presented. Optical chips containing multiple high-precision planar Bragg gratings are exploited as low-cost, robust refractive index sensors.

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SuNS microarray as novel biosensor for clinical diagnostics.
Pisanelli B., Dattilo D., Chetta M., Carducci F., De Ceglia G.

We here present an innovative microarray platform which aims to produce an higher standard of clinical microarray technology. The fabrication approach, involving a novel printing technology (Supramolecular Nano-Stamping) to reduce the production costs of the chips, together with a peculiar probe design, aiming to improve the assay sensitivity and workflow, intend to make the SuNS microarrays well poised to become an important element in the clinical diagnostics market.

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Bi-functional Magnetic Microcarriers for Point-of-Care Diagnostics
J.J. Palfreyman, D.M. Love, A.J. Philpott, K. Vyas, T. Mitrelias, C.H.W. Barnes

A novel type of microcarrier is presented, where a re-writable magnetic barcode is used to carry information. This technology has several advantages over the optical-based alternatives, whilst benefiting from the high-throughput of a microfluidic tool. Here, we present two different surface chemistries used to attach a probe and a control strand of DNA to an individual microcarrier. This is demonstrated with red and green fluorophores, clearly seen on either side.

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Chemically Modified Primers for Improved Multiplex PCR
Elena Hidalgo Ashrafi, Tony Le, Alexandre Lebedev, Richard Hogrefe, Victor Timoshchuk, Sabrina Shore, Inna Koukhareva and Natasha Paul

Multiplex PCR is an advantageous technique used in PCR applications to amplify multiple targets in a single reaction. As useful as it is, this technique presents a new set of challenges that further complicates PCR setup. For example, reactions are more prone to off-target amplifications such as mis-priming and primer dimer due to the increased number of primer pairs.

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Proteomic non-small cell lung carcinoma biomarker screening in bronchoalveolar lavage fluid
Tonio Oumeraci 1, Bernd Schmidt 3, Thomas Wolf 1,4, Marc Zapatka 4, Andreas Pich 2, Benedikt Brors 4, Roland Eils 4,5, Brigitte Schlegelberger 1, Nils von Neuhoff 1

Using a standardized method to acquire MALDI-TOF proteome profile spectra of bronchoalveolar lavage fluid (BALF), we have shown the upregulation of histatin 3 and calgranulin C in a small pilot cohort of NSCLC patients. This pilot study serves to demonstrate that it is feasible to screen a larger NSCLC patient cohort for BALF proteome level biomarkers in a clinical setting.

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Chemically Modified Primers for Improved Multiplexed PCR
Elena Hidalgo Ashrafi, Tony Le, Alexandre Lebedev, Richard Hogrefe, Victor Timoshchuk, Sabrina Shore, Inna Koukhareva and Natasha Paul

Multiplex PCR is an advantageous technique used in PCR applications to amplify multiple targets in a single reaction. As useful as it is, this technique presents a new set of challenges that further complicates PCR setup. For example, reactions are more prone to off-target amplifications such as mis-priming and primer dimer due to the increased number of primer pairs. Furthermore, preferential amplification of certain targets leads to an unequal distribution of amplicon products, making quantifi

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Hot Start dNTPs - A Novel Tool for Controlled Nucleotide Incorporation in PCR
Tony Le, Elena Hidalgo Ashrafi, Sabrina Shore, Victor Timoshchuk, Natasha Paul, Richard Hogrefe, Inna Koukhareva, Alexandre Lebedev

PCR is a widely used scientific tool employed by a variety of applications. Various Hot Start technologies have already been developed using modified PCR components to increase specificity of a reaction. Recently developed CleanAmpTM dNTPs are modified nucleoside triphosphates with a thermolabile 3’-tetrahydrofuranyl protecting group that is released at higher temperatures. These modified dNTPs prevent low temperature primer extension, which can often be a significant problem in PCR. At higher t

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Evaluation of microfluidic digital PCR for the detection of cancer biomarkers
Rebecca Sanders, Claire Bushell, Carole Foy, Daniel J. Scott

dPCR is achieved by sample partitioning prior to PCR amplification such that each reaction chamber contains one copy or less of target DNA. This dilution becomes the limiting factor and an accurate target molecule count is achievable. This study evaluates dPCR’s quantitative capabilities and investigates parameters influencing copy number quantification, using the Fluidigm Biomark instrument. Biomark technology combines dPCR theory with a microfluidics platform.

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Software for Genomic/Epigenomic Research
A.S.Tanas, V.V.Shkarupo, E.B.Kuznetsova, D.V.Zaletayev, V.V. Strelnikov

We present two computer programs: 1) AIMS in silico - a suggestion tool for Amplification of Intermethylated Sites experimental design and results analysis; and 2) PeakPick – a tool to view & analyse capillary electrophoregrams Our computer software is intended to standardize AIMS applications and to turn it into one of the principal approaches towards cancer methylomes studies as well as towards diagnostics in oncology, including early screening.

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Scientific News
Study Looks at the Diagnostic Utility of Whole-Genome Sequencing
New research explores the potential of whole genome sequencing to revolutionize the diagnosis of genetic disorders in a clinical setting.
Genetic Signature Enables Early, Accurate Sepsis Diagnosis
Systemic inflammation after injuries or surgery can dramatically alter the activity of thousands of genes, but a new study shows that changes in just 11 of them are enough to detect the presence or absence of accompanying infection.
Map Diagnostics Developing Mass Spec Test for Down Syndrome
The company hopes that this new test will provide an accessible, affordable and rapid alternative to current screening methods.
New Method For Measuring The Concentration Of Medicines In The Blood
Researchers at EPFL have come up with a quick and portable new device for measuring the amount of medicinal drugs in blood.
New Test Could Identify Resistant Tuberculosis Faster
The time needed to genetically sequence the bacteria causing tuberculosis from patient samples has been reduced from weeks to days using a new technique developed by a UCL-led team.
New Blood Test For Fibromyalgia Moves A Step Closer
New research could lead to a blood test to diagnose fibromyalgia.
Smartphone Video Microscope Automates Detection Of Parasites In Blood
A mobile phone-based video microscope developed by a UC Berkeley-led team, is as good as conventional blood smears in detecting levels of the Loa loa parasitic worm.
Blood Markers Could Help Predict Outcome Of Infant Heart Surgery
New research suggests it may be possible to predict an infant’s progress following surgery for congenital heart disease by analysing a number of important small molecules in the blood.
Proteomics Identifies DNA Repair Toolbox
Max-Planck scientists identify protein profiles of DNA repair.
Tiny Lab Devices Could Attack Huge Problem of Drug-Resistant Infections
NIH-funded project aims for fast identification and destruction of deadly bacteria.
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