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  Events - October 2012

The importance of (Bio) Pharmaceutical properties in Successful Drug Design

04 Oct 2012 - 04 Oct 2012 - NHLI, Kensington, London

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The pressing challenge pharmaceutical scientists can often be faced with is dealing with drug development candidate molecules with sub-optimal drug delivery or pharmaceutical properties. This symposium brings together international experts from both the pharmaceutical industry and academia to discuss (bio)pharmaceutical properties and strategies to optimise pharmaceutical development and minimise development impact. Small molecule NCE topics include a formulation road map for oral delivery, assessment of CMC developability using material efficiency indices, preclinical assessment of amorphous solid dispersion and case studies of the use of in the development of compounds with poor aqueous solubility, and new insights into the solubilisation, supersaturation and precipitation behaviour of APIs. Biopharmaceutical topics will include microparticle-protein interactions and strategies for optimising delivery and PK of biopharmaceuticals.

Session 1 : Introduction and Chair - Dr Andrew Ratcliffe, Cellzome
10.00   Prof Graham Buckton, Pharmaterials
The form and the formulation - strategy for oral delivery
10.50Dr Andrey Peresypkin, Vertex, USA
Pre-Clinical assessment of CMC developability of drug candidates by using material efficiency indices as the integral part of the translational product development strategy
11.40Dr Mark Saunders, Kuecept
Preclinical assessment of amorphous solid dispersions: friend or foe?

Session 2 : Chair - Dr Mo Alavijeh, Pharmidex

13.40Dr David Lyon, Bends Research, USA 
Use of amorphous dispersions in the development of compounds with poor aqueous solubility: Case studies from discovery to commercial
14.30Mr Karl Box, Sirius
Small-scale solubility and dissolution assays; new insights into solubilisation, supersaturation and precipitation behaviour of APIs
Session 3 : Chair - Dr Kate Brown, Imperial

Prof Ted Randolp, Centre for Pharmaceutical Biotechnology, USA
Microparticle-Protein interactions: Conformation, cavitation and immune response

16.30Dr Barry Moore, Xstalbio
Strategies for improving delivery, targeting and PK of Biopharmaceuticals

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