Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Events>This Event
  Events - December 2012


Tablet Formulation Development (2 day)

03 Dec 2012 - 04 Dec 2012 - London, UK



Bookmark and Share


This unique course introduces and integrates the key elements of tablet development with the principles of Quality by Design (QbD) with 2 days of theory plus an optional practical day in our development laboratory. It will include experimental, hands-on experience of formulation development using the Gamlen Tablet Press.

Topics include:

·    Applying Quality by Design at the development phase

·    Relating drug substance properties to desired formulation characteristics

·    Development formula and process - how these are linked

·    Identifying processes which will minimise development and manufacturing costs

·    Developing the Product Control Strategy - Critical Quality Attributes and Critical Process Parameters

·    Using novel science - PAT, NIR, Atomic Force Microscope, real time particle analysis

Proper integration of all of these elements is essential to achieve 'Quality by Design' because data from each phase is used to control the next step in the development process. By achieving proper integration based on sound scientific principles, many development and production problems can be avoided.


 

The course includes case studies of tablet formulation development and a detailed step by step analysis of all elements of the tablet manufacturing process. Hands on, practical studies will underpin the scientific learning in this participative course.


Who should attend?
The course is designed for people new to tablet development, and those requiring a refresher in the area. It will also benefit Process Development experts wishing to extend their understanding of why products processes can go wrong, and regulatory and quality personnel who need to understand the development process.

Course Programme:
Day 1 The Product Development Lifecycle
. Making sense of ICH Q8, 9 and 10—moving from theory to practice
. Designing formulations and processes to meet the Target Product Profile
. Formulation development—Formula and process selection
. Product Optimisation and the formulation cycle
. Developing Product Control Strategies at the formulation development phase
. Tablet Film Coating polymers
Day 2 Advance characterisation and development techniques
. Formulation mapping using X-ray and Raman spectroscopy
. AFM in formulation development
. Real time particle size analysis
. Dryer control using NIR
. Blend uniformity assessment using NIR and other techniques
. Compressibility comparison using the Gamlen Tablet Press
. Characterisation of tablet coats using THz spectroscopy
Day 3 Formulation development in practice (BOOK SEPARATELY) (HANDS ON. LIMITED TO 10 participants only)
. Material characterisation for product development
. Direct compression
. Wet granulation
. Drying
. Milling
. Compression
. Formulation evaluation and final selection
Wherever possible participants should bring practical problems and examples which can be reviewed on the course. The course will be highly participative and useful for people with or without formulation experience.

Course Speakers: Dr Michael Gamlen and Dr Dipankar Dey


Further information
Scientific News
Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
Leukemia’s Surroundings Key to its Growth
Researchers at The University of Texas at Austin have discovered that a type of cancer found primarily in children can grow only when signaled to do so by other nearby cells that are noncancerous.
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
‘Smelling’ Prostate Cancer
A research team from the University of Liverpool and the University of the West of England (UWE Bristol) has reached an important milestone towards creating a urine diagnostic test for prostate cancer that could mean that invasive diagnostic procedures that men currently undergo eventually become a thing of the past.
Genetic Mutation that Prevents Diabetes Complications
The most significant complications of diabetes include diabetic retinal disease, or retinopathy, and diabetic kidney disease, or nephropathy. Both involve damaged capillaries.
A Crystal Clear View of Biomolecules
Fundamental discovery triggers paradigm shift in crystallography.
Could the Food we Eat Affect Our Genes?
Almost all of our genes may be influenced by the food we eat, according to new research.
NIH Seeks Research Applications to Study Zika in Pregnancy, Developing Fetus
Institute has announced that the new effort seeks to understand virus effect on reproduction and child development.
Iron in the Blood Could Cause Cell Damage
Concentrations of iron similar to those delivered through standard treatments can trigger DNA damage within 10 minutes, when given to cells in the laboratory.
Criminal Justice Alcohol Program Linked to Decreased Mortality
Institute has announced that in the criminal justice alcohol program deaths dropped by 4.2 percent over six years.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!