18 Mar 2014 - 20 Mar 2014 - Nice, France
Medicinal chemists need to understand the relationship between chemical
structure and the physical properties of molecules and how this
translates into compound stability and the interaction of the molecule
with biological structures. These biological targets include proteins,
lipids, nucleic acids and cell membranes. Interaction of the molecules
with these targets affects the distribution of the compound in
biological systems and modulates biological function.
To do this
successfully the medicinal chemist needs to be aware of how target
selection is carried out and how this effects lead generation. The
medicinal chemist needs knowledge of structure property relationships,
the physico-chemical properties of drugs and how these molecules
interact with the body– pharmacokinetics and ADME (Absorption,
Distribution, Metabolism and Excretion).
The course also includes
an overview of the use of computational chemistry in virtual screening
and library design. The lectures are backed up by a number of case
studies and tutorial sessions, which involve the participants in using
the concepts discussed.