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  Events - December 2013


Advances in Electrophysiology Europe, 2013 – A Spotlight on Ion Channel Research – Highlighting Automated Physiology

10 Dec 2013 - 10 Dec 2013 - Saffron Walden, Cambridge, UK



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Advances in drug discovery technologies now allow ion channels to be significantly more promising targets for drug discovery. This meeting has been structured to focus on recent developments in patch clamp, which have revolutionised the use of electrophysiology as a tool for drug discovery and functional screening. An authoritative panel of experienced pharmaceutical industry scientists and academics has been assembled for this meeting that will have a special emphasis upon automated electrophysiology.

Professor David Brown, UCL, UK and Dr Edward Stevens, Pfizer Neusentis, UK will give the keynote presentations. Professor David Brown will discuss his far-reaching research into the regulation of ion channels that control neural excitability, with a special emphasis on his work with the Kv7 potassium channel. Drawing upon his extensive knowledge of the drug discovery industry both in CRO’s and pharmaceutical companies, Dr Edward Stevens will review the contribution that automated electrophysiology is making to drug discovery and development.

Speakers will then discuss the development and potential of these new technologies, present experimental results obtained with these systems and debate the potential impact of current technologies and future developments.

These presentations will include data from platforms including the IonWorks Barracuda®, IonWorks® Quattro™, PatchXpress® and IonFlux™ instrumentation:

  • Matthew Bridgland-Taylor, AstraZeneca, UK - Exploitation of the IonWorks Barracuda Automated Electrophysiology Platform to Improve Assessment of Cardiac Liability
  • Kelly Gatfield, GlaxoSmithKline, UK - Development of IonWorks Barracuda assays for use in early stage safety profiling
  • Gary Clarke, BioFocus DPI, UK - Ion Channel Drug Discovery: Case Study Utilising Automated Electrophysiology
  • Mark McPate, Novartis, UK - Investigation of the TRPC Channel using the IonWorks Quattro
  • Oliver Leven, GeneData, Switzerland - Genedata Screener for Automated Patch Clamping



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