Corporate Banner
Satellite Banner
Technology
Networks
Scientific Communities
 
Become a Member | Sign in
Home>Events>This Event
  Events - May 2014


47th Course of the International School of Crystallography

30 May 2014 - 08 Jun 2014 - Erice, Italy



Bookmark and Share


Diseases, from bacterial and viral infections to cancer to chronic maladies, are still among the greatest problems for mankind, in spite of tremendous progress in genetics, biology, and chemistry.  Approaches to developing new treatments have changed over time, and so have the methodologies used, in order to solve the varied, new, challenging problems that may happen on the path to drug discovery.  Together with ever-evolving experimental techniques, a variety of computational approaches have been applied at the various stages of the drug design process, and in the past two decades structure-based drug design has become one of the mainstream approaches.  This method can be used to target protein-ligand and protein-protein interactions and nowadays is applicable to all aspects of drug discovery, including lead identification, lead optimization, ADMET prediction, and drug repurposing. 

The purpose of the course is dual:

1) It will provide a review of the fundamentals and the application of crystallography to drug design, and an evaluation of the technology at the present state.

2) It will review the progress in this field and summarize the application and results to current fields of interest.  

In addition to lectures, there will be hands-on workshops providing training in using modern computer programs.

The topics that will be covered are:

- Targeting Resistance in Design of Anti AIDS Drugs

- Molecular Modeling and Drug Design

- Targeting Protein-Protein Interactions

- Drug Design Targeting Bromodomains

- Targeting GPCRs for Drug Design

- Targeting Influenza Virus Polymerase

- The Small Molecule Universe

- Molecular Obesity and Other Addictions in Drug Discovery

- Energetics of Protein-Ligand Interactions

- Docking Experiences and Expectations

- Structure of Human G-Protein Coupled Receptor

- Using ARP/WARP for Structure-Based Drug Design

- Antibody Technologies to Stabilize Targets for NCE Screening

- Drug Design Tales from AstraZeneca

- High Resolution Protein-Ligand Interactions by X-rays and Neutrons

- Virus Structure and Antiviral Drug Design

- Structure-Based Design of Drugs Against Diabetes

- Membrane Protein Structure

- Structural Bioinformatics

- Protein Aggregation and Drug Design

- Turning on Enzymes with Small Molecules



Further information
Scientific News
Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
Playing 'Tag' with Pollution lets Scientists See Who's It
Using a climate model that can tag sources of soot from different global regions and can track where it lands on the Tibetan Plateau, researchers have determined which areas around the plateau contribute the most soot — and where.
Women’s Immune System Genes Operate Differently from Men’s
A new technology reveals that immune system genes switch on and off differently in women and men, and the source of that variation is not primarily in the DNA.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
High-Resolution 3D Images Reveal the Muscle Mitochondrial Power Grid
NIH mouse study overturns scientific ideas on energy distribution in muscle.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Paving the way to Better Ovarian Cancer Diagnosis
Aïcha BenTaieb will present her invention for automated identification of ovarian cancer’s many subtypes at an international conference this fall.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!