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  Events - September 2014


SLAS Short Courses

01 Sep 2014 - 01 Sep 2014 - Manchester, UK



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The courses are complementary to the conference program; their objective is to educate people interested in these fields, providing an in-depth understanding of the topic and a comprehensive overview of the key techniques and recent developments. Delivered by distinguished faculty, these courses address a range of timely issues using real-world examples.

Later, in the conference, you can hear from researchers actively involved in these areas about their experiences and how the leading-edge is being explored !

The quality and educational content of SLAS short courses is well recognized and very well respected in our industry, and we are pleased to be partnering with SLAS to deliver these to you.

There is a charge to attend the short-courses, whilst the main Drug Discovery conference on Tue 2nd and Wed 3rd Sept remains free to attend ( please register for each separately ).

COURSE 1 : Introduction to Laboratory Automation

Jonathan Wingfield : AstraZeneca
Malcolm Crook : Peak Analysis & Automation

This introduction to automation course will provide a basic overview of when and how to successfully deploy automation within a laboratory environment. The course is tailored for managers who want to understand the strategic and tactical options for automation deployment. There will be an overview of the principles of automation architecture, infrastructure and laboratory informatics. There is no requirement for a working knowledge of, or experience with, automation.

View / download a full course summary.

COURSE 2 : High Content Screening: Instrumentation, Assay Development, Screening, Image and Data Analysis

Eberhard Krauß : ChemBioCon
Marc Bickle : Head HT-Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics

High-content screening is a powerful technology platform for implementing functional cell-based assays that allow truly multi-parametric analysis in the physiological context of intact cells. This course provides a state-of-the-art overview of the components of HCS (instrumentation, reagents, HC assay development, automated image analysis and multi-parametric data analysis, and data standards) together with some showcases of small molecule and RNAi high-content screens in industry and academia.

A demonstration will be given using the open source software CellProfiler how to analyze early endosomes in HeLa cells. Nuclei, cytosol and endosomes will be segmented and quantified. The resulting data will then be analyzed using the open source software KNIME. Parameters will be tested for normality, normalized and assembled into multiparametric profiles. The profiles will be quantified to estimate phenotypic strength and clustered to determine phenotypes. Both the slides describing the analysis and the pipelines will be made available to course participants to allow them to recreate the workflow in their own laboratories.

View / download a full course summary.

COURSE 3 : Establishing Cell-Based Assays and Implementing 3D Culture Models for screening and drug testing

Terry Riss : Senior Product Specialist, Cell Health, Promega Corporation
Jens Kelm : Insphero

This course will describe developing standard procedures for handling cultured cells to set up cell-based assays, describe techniques for measuring cell health and the mechanisms leading to cytotoxicity, and provide an overview of recent technological advances in 3D culture technologies that enable automation-compatible drug testing with more predictive and biologically relevant assays. Case studies will be presented which provide examples of using 3D model systems for screening and drug testing.

View / download a full course summary.



Further information
Scientific News
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Advances in molecular biology, coupled with the miniaturization and improved sensitivity of assays and devices in general, have enabled a new wave of point-of-care (POC) or “bedside” diagnostics.
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Scientists Find Lethal Vulnerability in Treatment-Resistant Lung Cancer
The study describes how the drug Selinexor killed lung cancer cells and shrank tumors in mice when used against cancers driven by the aggressive and difficult-to-treat KRAS cancer gene.
Drug to Treat Alcohol Use Disorder Shows Promise Among Drinkers With High Stress
The findings suggest that potential future studies with drugs targeting vasopressin blockade should focus on populations of people with AUD who also report high levels of stress.
C Dots Show Powerful Tumor Killing Effect
Nanoparticles known as Cornell dots, or C dots, have shown great promise as a therapeutic tool in the detection and treatment of cancer.
Charles River Acquires Agilux
Enhances Charles River’s early-stage capabilities in bioanalytical services.
Faecal Bacteria Linked to Body Fat
Researchers at King’s College London have found a new link between the diversity of bacteria in human poo – known as the human faecal microbiome - and levels of abdominal body fat.
How Baby’s Genes Influence Birth Weight And Later Life Disease
The large-scale study could help to target new ways of preventing and treating these diseases.
Genes Underlying Dogs’ Social Ability Revealed
The social ability of dogs is affected by genes that also seem to influence human behaviour, according to a new study from Linköping University in Sweden.
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