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  Events - September 2014


SLAS Short Courses

01 Sep 2014 - 01 Sep 2014 - Manchester, UK



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The courses are complementary to the conference program; their objective is to educate people interested in these fields, providing an in-depth understanding of the topic and a comprehensive overview of the key techniques and recent developments. Delivered by distinguished faculty, these courses address a range of timely issues using real-world examples.

Later, in the conference, you can hear from researchers actively involved in these areas about their experiences and how the leading-edge is being explored !

The quality and educational content of SLAS short courses is well recognized and very well respected in our industry, and we are pleased to be partnering with SLAS to deliver these to you.

There is a charge to attend the short-courses, whilst the main Drug Discovery conference on Tue 2nd and Wed 3rd Sept remains free to attend ( please register for each separately ).

COURSE 1 : Introduction to Laboratory Automation

Jonathan Wingfield : AstraZeneca
Malcolm Crook : Peak Analysis & Automation

This introduction to automation course will provide a basic overview of when and how to successfully deploy automation within a laboratory environment. The course is tailored for managers who want to understand the strategic and tactical options for automation deployment. There will be an overview of the principles of automation architecture, infrastructure and laboratory informatics. There is no requirement for a working knowledge of, or experience with, automation.

View / download a full course summary.

COURSE 2 : High Content Screening: Instrumentation, Assay Development, Screening, Image and Data Analysis

Eberhard Krauß : ChemBioCon
Marc Bickle : Head HT-Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics

High-content screening is a powerful technology platform for implementing functional cell-based assays that allow truly multi-parametric analysis in the physiological context of intact cells. This course provides a state-of-the-art overview of the components of HCS (instrumentation, reagents, HC assay development, automated image analysis and multi-parametric data analysis, and data standards) together with some showcases of small molecule and RNAi high-content screens in industry and academia.

A demonstration will be given using the open source software CellProfiler how to analyze early endosomes in HeLa cells. Nuclei, cytosol and endosomes will be segmented and quantified. The resulting data will then be analyzed using the open source software KNIME. Parameters will be tested for normality, normalized and assembled into multiparametric profiles. The profiles will be quantified to estimate phenotypic strength and clustered to determine phenotypes. Both the slides describing the analysis and the pipelines will be made available to course participants to allow them to recreate the workflow in their own laboratories.

View / download a full course summary.

COURSE 3 : Establishing Cell-Based Assays and Implementing 3D Culture Models for screening and drug testing

Terry Riss : Senior Product Specialist, Cell Health, Promega Corporation
Jens Kelm : Insphero

This course will describe developing standard procedures for handling cultured cells to set up cell-based assays, describe techniques for measuring cell health and the mechanisms leading to cytotoxicity, and provide an overview of recent technological advances in 3D culture technologies that enable automation-compatible drug testing with more predictive and biologically relevant assays. Case studies will be presented which provide examples of using 3D model systems for screening and drug testing.

View / download a full course summary.



Further information
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Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Intracellular Microlasers Could Allow Precise Labeling of up to a Trillion Individual Cells
MGH investigators have induced structures incorporated within individual cells to produce laser light at wavelengths that differ based on the size, shape and composition of each microlaser, allowing precise labeling of individual cells.
Real-Time Imaging of Lung Lesions During Surgery
Targeted molecular agents cause lung adenocarcinomas to fluoresce during surgery, according to pilot report.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Protein Related to Long Term Traumatic Brain Injury Complications Discovered
NIH-study shows protein found at higher levels in military members who have suffered multiple TBIs.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
New Vaccine For Chlamydia to Use Synthetic Biology
Prokarium Ltd, a biotechnology company developing transformational oral vaccines, have announced new funding from SynbiCITE, the UK’s Innovation and Knowledge Centre for Synthetic Biology.
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