Corporate Banner
Satellite Banner
Food & Beverage Analysis
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

MSU Researchers Decode Deadly E. coli Strain

Published: Friday, August 24, 2012
Last Updated: Friday, August 24, 2012
Bookmark and Share
Highly virulent strain of E. coli lead to 54 deaths in Germany.

A highly virulent strain of E. coli caused the deadliest E. coli outbreak on record last year, leading to 54 deaths in Germany and sickening more than 3,800 people.

Now a research team at Michigan State University has decoded the pathogen and is working on ways to curb the effects of the bacteria.

The E. coli O104:H4 strain shares some of the same characteristics as other deadly E. coli bacteria, but its combination is novel. The MSU team determined that a key process in the bacteria’s effectiveness lies in its biofilm.

As a grouping of the bacteria stick to a cell’s surface, they grow encased in a self-produced protective coat, or biofilm.

Once this film forms, it begins to make more toxic genes like the Shiga toxin. This increased production of toxic genes is the likely cause of the intensity of the deadly E. coli outbreak.

“What made the German outbreak so different is that many victims suffering from kidney failure were adults,” said Shannon Manning, MSU Molecular Biologist and Epidemiologist. “Rather than attacking adults, other types of E. coli that produce Shiga toxins typically damage kidneys of children under 10.”

The researchers also discovered that the H4 strain needs a lengthier period of time to form this toxic-producing biofilm, helping to explain the considerably longer incubation time seen among individuals infected with the German outbreak strain compared to individuals infected with other types of E. coli.

The team will next apply this knowledge towards mitigating the effects of the strain.

“Our research demonstrates that biofilm formation is critical for toxin production and kidney damage,” said Manning. “If we can block the bacteria from forming a stable biofilm, then it is likely that we can prevent future E. coli O104:H4 infections.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
How To Keep Your Rice Arsenic-Free
Researchers at Queen’s University Belfast have made a breakthrough in discovering how to lower worrying levels of arsenic in rice that is eaten all over the world.
Pesticide Found in 70 Percent of Massachusetts’ Honey Samples
New Harvard University study says that the pesticide commonly found in honey samples is implicated in Colony Collapse Disorder.
Printed "Smart Cap" Detects Spoiled Food
It might not be long before consumers can just hit “print” to create an electronic circuit or wireless sensor in the comfort of their homes.
Red Wine Antioxidant May Provide New Cancer Therapy Options
Resveratrol and quercetin, two polyphenols that have been widely studied for their health properties, may soon become the basis of an important new advance in cancer treatment,
New Research will Show How the Environment Could Change the Way We Eat
A new study funded by the Wellcome Trust will investigate how environmental changes over the next 20-30 years may impact the way we eat, in the UK and worldwide.
Blue LEDs Can be Used to Preserve Food
Blue light emitting diodes (LEDs) have strong antibacterial effect on major foodborne pathogens and can be used as a chemical-free food preservation method, a new study has found.
FDA Declares Trans Fatty Acids Unsafe for Consumption
TFAs are widely recognized as the most harmful fat with regard to causing cardiovascular disease (CVD).
Fat, Sugar Cause Bacterial Changes that may Relate to Loss of Cognitive Function
A study has indicated that both a high-fat and a high-sugar diet, compared to a normal diet, cause changes in gut bacteria that appear related to a significant loss of "cognitive flexibility," or the power to adapt and adjust to changing situations.
How Anthrax Spores Grow in Cultured Human Tissues
New findings to help predict risk and outcomes of anthrax attacks.
Food Research at the Microscale
Thermal stage microscopy allows food science microscopists to analyze samples under a range of conditions.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!