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Webcasts
Advancements in Automated Sample Preparation, STR-PCR, and CE Detection for Rapid Nucleic Acid Analysis on an Integrated Microfluidic PlatformAdvancements in Automated Sample Preparation, STR-PCR, and CE Detection for Rapid Nucleic Acid Analysis on an Integrated Microfluidic Platform
Professor Frederic Zenhausem, Center for Applied Nanobioscience and Medicine, speaking at Lab on a Chip World Congress 2013.
The Detection of Transcription Errors in Biological SystemsThe Detection of Transcription Errors in Biological Systems
Kelley Thomas, University of New Hampshire, speaking at Genomics Research 2013.

Market Reports
Scientific News
Portable Kit Can Recover Traces of Chemical Evidence
A chemist at the National Institute of Standards and Technology (NIST) has developed a portable version of his method for recovering trace chemicals such as environmental pollutants and forensic evidence including secret graves and arson fire debris.
Forensics Professor Detects Blood on Revolutionary War Projectiles
More than 230 years after the Revolutionary War ended, Edinboro University professor of forensic science Dr. Ted Yeshion has found the presence of blood on buckshot recovered from a battlefield in upstate New York.
Single Molecule Detection of Contaminants, Explosives or Diseases
A technique that combines the ultrasensitivity of surface-enhanced Raman scattering (SERS) with a slippery surface invented by Penn State researchers will make it feasible to detect single molecules of a number of chemical and biological species from gaseous, liquid or solid samples.
Potential New Tool for Forensic Science
Microbial communities associated with humans tick in predictable, clock-like succession following death.
Perfecting Age Estimations Under 25
The Idaho State University Department of Anthropology has received a $510,409 grant from the National Institute of Justice to develop forensic science techniques to better identify individuals under 25 years of age for criminal justice purposes.
Identifying Gender from a Fingerprint
Culprits beware, a University at Albany research group, led by assistant chemistry professor Jan Halámek, is taking crime scene fingerprint identification to a new level.
Viruses, Too, Are Our Fingerprint
A group of researchers from the University of Helsinki and the University of Edinburgh have been the first to find the genetic material of a human virus from old human bones.
Questioning the Validity of Forensic DNA Match Statistic
Fifteen years of criminal cases with affected mixture evidence.
Study Raises Questions About DNA Evidence
University of Indianapolis researchers say contamination through secondary transfer of material could implicate the innocent or help the guilty go free.
'Forensic Toolkit’ to Improve Evidence Detection and Analysis
Students from The University of Dundee have been developing a forensic `toolkit’ that will allow investigators to determine the age of fingerprints, detect traces of steel on bone from stabbings, and produce a biosensitive spray that can reveal traces of bodily fluids at crime scenes.
Business News
It is All About the Product, Right?
Technology Networks met with Waters Corporation at its head office in Milford, MA to better understand the factors they use to drive business success.
Growing Demand for Technologies to Tackle Cybercrime to Drive Digital Forensics Market
The market is expected to reach US$4.97B by the end of 2021 at a positive CAGR of 12.5%.
Pressure Bio, Florida International University Collaborate
Collaboration will combine the advantages of PBI's PCT platform with the forensic experience and expertise of FIU, with a goal to help reduce the rape kit testing backlog.
Thermo Scientific Manufacturing Site to Meet Guidelines for 18385 Certification
A new standard proposed by the International Organization for Standardization.
50+ Forensic DNA Experts to Present at the 2015 International Symposium on Human Identification (ISHI)
Learn from forensic luminaries, who will share their experiences solving crimes, deciphering historical mysteries and advancing the fields of forensics and DNA analysis, at the International Symposium on Human Identification (ISHI).
Is a Vital Forensic Skill Dying Out?
Forensic fibre examination is one of the most established forensic evidence types.
Hamilton Storage Announces Formation of Hamilton Storage GmbH
New subsidiary to serve Europe, the Middle East, Africa and Asia.
New Members of U.S National Commission on Forensic Science Announced
The U.S. Department of Justice (DOJ) and the U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) today announced six appointments to the National Commission on Forensic Science.
Center for Improving Statistical Analysis of Forensic Evidence
The U.S. Commerce Department’s National Institute of Standards and Technology has awarded Iowa State University up to $20 million over five years to establish a Forensic Science Center of Excellence focused on pattern and digital evidence.
Agilent to Focus on "Powerful Partnerships, Inspiring Results" at ASMS 2015
Company to introduce solutions enabling new standards in mass spectrometry, lab productivity.

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14 Mar 2016
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19 Apr 2016
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ePosters
A Simple Plate Based Assay Using pH Sensor Dye to Screen for Internalizing Antibody
Promega Corporation

Receptor mediated internalization is a key mechanism of action (MOA) for antibody drug conjugates (ADCs). However, current methods of studying antibody internalization have several limitations including: 1) A multistep process not suitable for screening; 2) Low signal-to-background ratios; 3) Not suitable for kinetic measurements. We have developed a method that mitigates problems associated with traditional internalization assays.
An IgG Cleaving Protease from S equi with Improved Activity Against Mouse IgGs
Promega Corporation

Here we have expressed and purified a modified recombinant IdeZ, and show that it has significantly improved activity against mouse IgG2a and IgG3 subclasses when compared to IdeS. We also demonstrate the use of IdeZ in LC-MS workflows for human and mouse IgG characterization.
Minimizing Carry-over for High Throughput Analysis
1FHNW Fachhochschule Nordwestschweiz, Hochschule für Life Sciences Gründenstrasse 40 CH-4132 Muttenz; 2CTC Analytics AG Industriestrasse 20 CH-4222 Zwingen; Switzerland

Minimal carry-over is a prerequisite for high throughput analysis. However, minimized carry-over and cycle time are competing and a careful optimization is mandatory. In this study the influence of wash conditions on carry-over of various compounds was investigated. A strategy to minimize carry-over was developed. The influences of different wash tasks were investigated. Finally the contribution of different system components such as injector valve or column was studied.
A Comparison of ITEX Dynamic Headspace–GC/MS to other Enrichment Techniques for Analysis of Flavoring Compounds
1Aspen Research Corporation, Maple Grove, MN; 2CTC Analytics, Zwingen, Switzerland

Enrichment techniques are commonly used for the analysis of flavoring compounds in different matrices with GC/MS. Analysis of flavoring compounds is done by purge & trap, SPME or headspace, depending on requirements for sensitivity. The In-Tube Ex¬traction (ITEX) Dynamic Headspace uses a micro trap filled with an adsorbent material to efficiently extract the compounds. Here we evaluate if the ITEX can be used to effectively analyze for these compounds and reduce the analyst’s time involved.
Automated in-gel digestion on a commercial autosampler directly coupled to nanoLC-MS/MS
University of Bern, Department of Clinical Research, Proteomics & Mass Spectrometry Core Facility, Bern, Switzerland : CTC Analytics AG, Zwingen, Switzerland

SDS-PAGE separates protein samples from LC-MS incompatible contaminations, and is frequently used to fractionate proteins of entire proteomes. One disadvantage is that gel lanes have to be cut into many slices, followed by in-gel digestion of proteins and extraction of peptides. The number of these gel slices goes into the hundreds, rendering this process very repetitive and prone to mistakes and errors during sample handling. Automation reduces such risks and improves reproducibility.
Automated sample preparation workflows for quantitative proteomics applications
1Max Delbrück Center for Molecular Medicine in the Helmholtz Association, MDC, Berlin, Germany; 2CTC Analytics, Zwingen, Switzerland; 3Axel Semrau GmbH, Sprockhövel, Germany

Mass spectrometry based proteomics requires large scale identification of peptides, and depends upon efficient sample preparation. Recently, we presented two automated protein-digestion setups, in-solution and in-gel digestion. We extended these techniques by implementing dimethyl labelling (DML). Furthermore, we established an automated phospho-peptide (PP) enrichment procedure in a 96-well formate, generating phospho-proteomic data in very short time.
Optimization of a Vacuum Ultraviolet Photoionization source for Gas Chromatography used with a High Resolution Time of Flight Mass Spectrometer
LECO Corporation

-Tune solution allows optimization of ion source parameters for
both proton transfer and direct ionization
-Independent ionization processes exist for M+ and MH+
-Optimizing for dopant signal intensity yields inferior results
-Degree of fragmentation remains relatively constant over a
range of source conditions
High Performance Comprehensive Two-Dimensional Gas Chromatography Coupled with a High Resolution Multi-Reflecting TOFMS for Confident Non-Target Analyte Identification
LECO Corporation, Restek Corporation

The use of comprehensive two-dimensional gas chromatography to help increase chromatographic resolution is a major step in tackling the problem of confident peak identification in a complex sample matrix. Combining the separation power of two-dimensional gas chromatography, with resolving power greater than 25,000, and sub ppm mass accuracies of a high resolution multi-reflecting TOFMS is the ideal solution to confident compound identification within a complex sample matrix.
Fragmentation Trees for Automated de novo Interpretation of Impure Electron Ionization Spectra from Gas Chromatographic Complex Mixture Analysis—Chemical Deconvolution
LECO Corporation, Mass Spectrometry Consulting Ltd., Moscow State University

-Chemical deconvolution algorithms accurately reported independent
components of dead coelutions where such components belong to distinct chemical classes.
-Present algorithms fail to distinguish chemically similar analytes such as branched and linear alkanes, thus chemical deconvolution is not a
substitute for GCxGC.
-Chemical deconvolution algorithms accurately rejected more than 80% of spurious signals from manually curated spectra found to be contaminated with unrelated signa
Effective Comparison of Yeast Extracts Using High Resolution GC and GCxGC-HRTOFMS
LECO Corporation

The Pegasus GC-HRT and GC-HRT 4D instruments are effective tools for the comprehensive analysis of yeast extracts.
• Enhanced chromatographic resolution of the HRT 4D system facilitated compound characterization by improving spectral similarity scores
• High quality data resulted in excellent spectral similarity scores when compared to large, well-established databases (NIST, Wiley)
• High resolution, accurate mass data was crucial for determination of fragment, molecular, and adduct
Application Notes
Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks using Morphologically Directed Raman Spectroscopy
Malvern Instruments Limited

This application note details how Morphologically Directed Raman Spectroscopy (MDRS) using the Morphologi G3-ID can be applied to the forensic identification of commercially sourced white powders commonly used in hoax powder attacks.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Trends, Challenges and Strategy in the Forensic Science Sector
Netherlands Forensic Institute

The forensic science sector is in transition. New insights, technologies, and customers, combined with falling costs and increasing capabilities cause the sector to grow rapidly. As a consequence the role of forensic laboratories is changing.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform
SCIEX

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry
SCIEX

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples
SCIEX

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
A Complete Forensic Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
Thermo Scientific

Implementation of liquid chromatography-mass spectrometry (LC-MS) for forensic toxicology screening provides specific and sensitive analysis of drugs and toxic substances.
Performance Evaluation of a Thermal Desorption System for Detection of Basic Drugs in Forensic Samples by GC/MS
GERSTEL Inc.

Stir bar sorptive extraction (SBSE) is an innovative sample extraction technique that can be used to process blood, urine, and tissue samples for routine drug screening in the forensic toxicology laboratory.
Toxicological Screening with the Agilent 6500 Series Accurate_mass Q-TOF LC/MS and personal Compound Database and Library using the Brorcker, Herre and Pragst Accurate Mass Spectral Library
Agilent Technologies

Screening using accurate mass measurement and a large database containing compounds of toxicological and forensic concern is possible with the Agilent Forensic Toxicology Personal Compound Database.
Toxtyper™ – a Comprehensive LC-MSn Screening Solution for Clinical and Forensic Toxicology
Bruker Corporation

In the clinic and the routine lab, fast and unambiguous identification of toxic compounds is the primary task. The screening solution presented here is based on ultrahigh performance liquid chromatography (UHPLC) coupled to an LC-MSn ion trap system.
SELECTBIO

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