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Advancements in Automated Sample Preparation, STR-PCR, and CE Detection for Rapid Nucleic Acid Analysis on an Integrated Microfluidic PlatformAdvancements in Automated Sample Preparation, STR-PCR, and CE Detection for Rapid Nucleic Acid Analysis on an Integrated Microfluidic Platform
Professor Frederic Zenhausem, Center for Applied Nanobioscience and Medicine, speaking at Lab on a Chip World Congress 2013.
The Detection of Transcription Errors in Biological SystemsThe Detection of Transcription Errors in Biological Systems
Kelley Thomas, University of New Hampshire, speaking at Genomics Research 2013.

Market Reports
Scientific News
Questioning the Validity of Forensic DNA Match Statistic
Fifteen years of criminal cases with affected mixture evidence.
Study Raises Questions About DNA Evidence
University of Indianapolis researchers say contamination through secondary transfer of material could implicate the innocent or help the guilty go free.
'Forensic Toolkit’ to Improve Evidence Detection and Analysis
Students from The University of Dundee have been developing a forensic `toolkit’ that will allow investigators to determine the age of fingerprints, detect traces of steel on bone from stabbings, and produce a biosensitive spray that can reveal traces of bodily fluids at crime scenes.
Glowing Fingerprints to Fight Crime
A CSIRO scientist who had his home broken into has developed a new crime scene identification technique to help fingerprint criminals.
Forensic Facial Examiners Can Be Near Perfect
In what might be the first face-off of its kind, trained forensics examiners from the FBI and law enforcement agencies worldwide were far more accurate in identifying faces in photographs than nonexperts and even computers.
Ancestral Background Can Be Determined By Fingerprints
A proof-of-concept study finds that it is possible to identify an individual’s ancestral background based on his or her fingerprint characteristics – a discovery with significant applications for law enforcement and anthropological research.
CSI -- On The Metabolite's Trail
Bioinformaticians at the University of Jena make the most efficient search engine for molecular structures available online.
People Emit Their Own Personal Microbial Cloud
We each give off millions of bacteria from our human microbiome to the air around us every day, and that cloud of bacteria can be traced back to an individual.
Blood, Teeth Samples Predict a Criminal's Age
Forensic biomedical scientists from KU Leuven have developed a test to predict individuals’ age on the basis of blood or teeth samples. This test may be particularly useful for the police, as it can help track down criminals or identify human remains.
Contactless Fingerprint Technology is Coming
Quickly moving through security checkpoints by showing your hand to a scanner seems straight out of science fiction, but NIST is working with industry to bring fast, touchless fingerprint readers out of the lab and into the marketplace.
Business News
Growing Demand for Technologies to Tackle Cybercrime to Drive Digital Forensics Market
The market is expected to reach US$4.97B by the end of 2021 at a positive CAGR of 12.5%.
Pressure Bio, Florida International University Collaborate
Collaboration will combine the advantages of PBI's PCT platform with the forensic experience and expertise of FIU, with a goal to help reduce the rape kit testing backlog.
Thermo Scientific Manufacturing Site to Meet Guidelines for 18385 Certification
A new standard proposed by the International Organization for Standardization.
50+ Forensic DNA Experts to Present at the 2015 International Symposium on Human Identification (ISHI)
Learn from forensic luminaries, who will share their experiences solving crimes, deciphering historical mysteries and advancing the fields of forensics and DNA analysis, at the International Symposium on Human Identification (ISHI).
Is a Vital Forensic Skill Dying Out?
Forensic fibre examination is one of the most established forensic evidence types.
Hamilton Storage Announces Formation of Hamilton Storage GmbH
New subsidiary to serve Europe, the Middle East, Africa and Asia.
New Members of U.S National Commission on Forensic Science Announced
The U.S. Department of Justice (DOJ) and the U.S. Department of Commerce’s National Institute of Standards and Technology (NIST) today announced six appointments to the National Commission on Forensic Science.
Center for Improving Statistical Analysis of Forensic Evidence
The U.S. Commerce Department’s National Institute of Standards and Technology has awarded Iowa State University up to $20 million over five years to establish a Forensic Science Center of Excellence focused on pattern and digital evidence.
Agilent to Focus on "Powerful Partnerships, Inspiring Results" at ASMS 2015
Company to introduce solutions enabling new standards in mass spectrometry, lab productivity.
Linkam and Cambridge IVF Collaborate to Develop New Protocols for Sperm Testing
The two companies are working together to develop new instrumentation and protocols to improve the reliability of sperm testing.

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Spice Wars- Are You Battle Ready? Analysis of Synthetic Cannabinoids via Gas Chromatography—High Resolution Time-of-Flight Mass Spectrometry
LECO Corporation, Berrien County Forensic Laboratory

-EI/CI workflow facilitates confident compound identification.
-GC-HRT and HR-CI source provides high quality, accurate mass data for:
-Database searches (NIST, Wiley, etc.)
-Formula determination (fragment, molecular, and adduct ions)
Aptamer-Based Electrochemical Biosensing Platform for Detection of Hormonal Pollutants in Water
Université du Québec à Montréal, INRS-EMT

A novel detection mechanism based on aptamers has been developed to detect small molecules as hormones, antibiotics, toxins, drugs, etc. For first time, an aptasensor to detect progesterone has been developed.
Mixtures Analysis of Complex Mixtures
Mestrelab Research

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
Utilization of Hydrogen Carrier Gas on a High Resolution GC-TOFMS System: An Application Compendium
LECO Corporation

GC-HRT methods utilizing hydrogen carrier gas were developed for analysis of representative specialty chemical, forensic, and metabolomic markets.
General Workflow For Confident Identification of Unknown Compounds in Forensic, Petroleum, Food, Environmental, and Biological Materials: The GC-HRT Advantage
LECO Corporation

GC-HRT is an indispensable tool for complex sample analysis.
-Accurate mass measurements can be leveraged to calculate robust chemical formulae
-A workflow that includes complementary EI and CI-HRT analysis results for rigorous compound indentification
Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements
U.S. Food and Drug Administration, Forensic Chemistry Center

A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.
A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies
The University of Tampa Department of Chemistry, Biochemistry, and Physics, Gerling Applied Engineering

Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Denator AB

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System
Agilent Technologies

Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.
Novel, Fully Automated Method Allows Efficient Analysis of qPCR Data for Qualitative Calling Based on Comparative Cq
Azure PCR Limited

Assessment to ascertain if a method for analysis of qPCR data dependent on manual intervention can be replaced by automated analysis using the AzurePCRTM method.
Application Notes
Forensic Analysis of an Artificial Sweetener Commonly Employed in Hoax Powder Attacks using Morphologically Directed Raman Spectroscopy
Malvern Instruments Limited

This application note details how Morphologically Directed Raman Spectroscopy (MDRS) using the Morphologi G3-ID can be applied to the forensic identification of commercially sourced white powders commonly used in hoax powder attacks.
Sample preparation with the AC Extraction Plate: extraction of urinary THC metabolites for LC-MSMS quantification
Tecan Group Ltd.

In many countries, routine workplace drug testing involves screening for the free THC-COOH metabolite obtained by hydrolyzing THC-COOH glucuronide. Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Trends, Challenges and Strategy in the Forensic Science Sector
Netherlands Forensic Institute

The forensic science sector is in transition. New insights, technologies, and customers, combined with falling costs and increasing capabilities cause the sector to grow rapidly. As a consequence the role of forensic laboratories is changing.
The Analysis of Common Drugs of Abuse in an Oral Fluid Matrix using a New Q TRAP® Platform

The multiplexing analysis of several compound classes, such as common prescription drugs along with drugs of abuse is very important. The measurement of these drugs has generally been performed using urine as the sample matrix. However, many research laboratories are finding the need to analyze these compounds in oral fluid matrices.
Quantification of Ethylglucuronide in hair by Liquid Chromatography Tandem Mass Spectrometry

An advantage of the use of ethylglucuronide (ETG) in hair is that it is not subject to the effect of bacteria. It also offers the opportunity to extend the window of detection up to 6 months compared to hours- days in blood and urine.
Advanced Automated Library Searching for Compound Identification in Forensic Toxicology Samples

LC-MS/MS utilization in forensic toxicology screening for drugs and drug metabolites has become increasingly popular due to the selectivity, sensitivity and the speed of LC-MS/MS analysis. MS/MS confirmation with automated searching against available spectral libraries has proven to add a superior level of confidence to the compound identification.
A Complete Forensic Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
Thermo Scientific

Implementation of liquid chromatography-mass spectrometry (LC-MS) for forensic toxicology screening provides specific and sensitive analysis of drugs and toxic substances.
Performance Evaluation of a Thermal Desorption System for Detection of Basic Drugs in Forensic Samples by GC/MS

Stir bar sorptive extraction (SBSE) is an innovative sample extraction technique that can be used to process blood, urine, and tissue samples for routine drug screening in the forensic toxicology laboratory.
Toxicological Screening with the Agilent 6500 Series Accurate_mass Q-TOF LC/MS and personal Compound Database and Library using the Brorcker, Herre and Pragst Accurate Mass Spectral Library
Agilent Technologies

Screening using accurate mass measurement and a large database containing compounds of toxicological and forensic concern is possible with the Agilent Forensic Toxicology Personal Compound Database.
Toxtyper™ – a Comprehensive LC-MSn Screening Solution for Clinical and Forensic Toxicology
Bruker Corporation

In the clinic and the routine lab, fast and unambiguous identification of toxic compounds is the primary task. The screening solution presented here is based on ultrahigh performance liquid chromatography (UHPLC) coupled to an LC-MSn ion trap system.

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