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Wednesday, July 23, 2014
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Comparison of Three Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development
Gary dos Santos and Emer Clarke

Objective: To identify an assay that can accurately predict the risk of CRS and CS associated with investigational biotherapeutics. A comparison of three methods were used: (a) immobilization of test antibody on plastic, (b) co-culture of PBMC's on HUVEC's and (c) pre-culture of PBMC's at high cell density.

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Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements
Sarah E. Voelker, M.S.; Travis M. Falconer, Ph.D.; Jonathan J. Litzau; Mary B. Jones; Lisa M. Lorenz

A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.

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A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies
Hilary Brown, Jennifer Speer, John Gerling, and Kenyon Evans-Nguyen

Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
Syed Kashif Zafar, Syed Tarique Moin and Zaheer-ul-Haq

MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.

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Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
M.M. Rahman, B. S. Mohsina, K.M. Sharif, B. Y. Kamaruzzaman, M. B. Awang

Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.

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Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
Dos Santos G, Mergaert A and Clarke E.

This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.

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High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System
Arunkumar Padmanaban, Ruediger Salowsky, Adam Inche

Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.

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Novel Antimalarial Drug Candidates Generated In Silico by Analysis of Public HTS Data
Robert Fraczkiewicz, Michael S. Lawless, Robert D. Clark, and Walter S. Woltosz

This research aims to provide proof-in-principle that in silico tools could be applied to public data so as to efficiently identify active chemistry with good ADMET properties.

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Novel, Fully Automated Method Allows Efficient Analysis of qPCR Data for Qualitative Calling Based on Comparative Cq
Collaborative research by Pioneer Hi-Bred (a DuPont company) and Azure PCR Limited

Assessment to ascertain if a method for analysis of qPCR data dependent on manual intervention can be replaced by automated analysis using the AzurePCRTM method.

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Showing Results 1 - 10 of 13
Scientific News
Using Forensic Technology to Track Down Drug Residues in Milk
Veterinarians at Iowa State University are using advanced forensic techniques and the same technology used by crime scene investigators to monitor drug residues in milk and meat.
Technique Offers Arson Investigators Faster, More Accurate Results
The new process for analyzing debris for traces of fire accelerants is faster and more accurate than conventional methods and produces less waste.
Truth About Richard III’s Spinal Condition Uncovered
Scientists use 3D scans in research led by the University of Leicester, working with the University of Cambridge, Loughborough University and University Hospitals of Leicester.
ELISA Screening to Monitor Illegal and Legal Drugs in Hair and Urine
The German driving licence re-granting programme uses cut-offs many orders of magnitude below the conventional cut-offs and hence below what most of the commercially available screening kits were manufactured for.
Detecting Trace Amounts of Explosives With Light
The sensor that can detect tiny quantities of explosives with the use of light and special glass fibres.
Will Forensic Biology Become Forensic Molecular Biology?
The article presents some examples of the potential for new molecular biology technologies to assist in the investigation of crime.
Fluorescent Sensor Detects Date Rape Drug Within Seconds
The sensor, developed by researchers from the National University of Singapore (NUS), identifies the presence of GHB, a drug known commonly used to spike beverages.
Innovative Fingerprint Analysis is Trialled by Police
Pioneering technology designed by Sheffield Hallam University to provide an in-depth analysis of fingerprints is being tried and tested at crime scenes.
What can Investigators Really Tell from Gunshot Residue?
Researchers have developed a novel approach to improve gunshot residue fingerprinting to rapidly detect a wider range of particles than existing methods.
3-D Model Links Facial Features and DNA
An international team of researchers is beginning to connect genetics with facial features, degrees of femininity and racial admixture.
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