|Spice Wars- Are You Battle Ready? Analysis of Synthetic Cannabinoids via Gas Chromatography—High Resolution Time-of-Flight Mass Spectrometry|
David E. Alonso, John Rorabeck, and Joe Binkley
-EI/CI workflow facilitates confident compound identification.
-GC-HRT and HR-CI source provides high quality, accurate mass data for:
-Database searches (NIST, Wiley, etc.)
-Formula determination (fragment, molecular, and adduct ions)
|Aptamer-Based Electrochemical Biosensing Platform for Detection of Hormonal Pollutants in Water|
Contreras Jimenez, G.; Eissa, S.; Ng, A.; Zourob, M.; Siaj, M.
A novel detection mechanism based on aptamers has been developed to detect small molecules as hormones, antibiotics, toxins, drugs, etc. For first time, an aptasensor to detect progesterone has been developed.
|Mixtures Analysis of Complex Mixtures|
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba
We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
|Utilization of Hydrogen Carrier Gas on a High Resolution GC-TOFMS System: An Application Compendium|
Joe Binkley, David Alonso
GC-HRT methods utilizing hydrogen carrier gas were developed for analysis of representative specialty chemical, forensic, and metabolomic markets.
|General Workflow For Confident Identification of Unknown Compounds in Forensic, Petroleum, Food, Environmental, and Biological Materials: The GC-HRT Advantage|
David E. Alonso, Clecio Klitzke, Liz Humston-Fulmer, Jonathan Byer, and Joe Binkley
GC-HRT is an indispensable tool for complex sample analysis.
-Accurate mass measurements can be leveraged to calculate robust chemical formulae
-A workflow that includes complementary EI and CI-HRT analysis results for rigorous compound indentification
|Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements|
Sarah E. Voelker, M.S.; Travis M. Falconer, Ph.D.; Jonathan J. Litzau; Mary B. Jones; Lisa M. Lorenz
A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.
|A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies|
Hilary Brown, Jennifer Speer, John Gerling, and Kenyon Evans-Nguyen
Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.
|High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System|
Arunkumar Padmanaban, Ruediger Salowsky, Adam Inche
Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.
|Novel, Fully Automated Method Allows Efficient Analysis of qPCR Data for Qualitative Calling Based on Comparative Cq|
Collaborative research by Pioneer Hi-Bred (a DuPont company) and Azure PCR Limited
Assessment to ascertain if a method for analysis of qPCR data dependent on manual intervention can be replaced by automated analysis using the AzurePCRTM method.
|An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals|
Kiril Lanevskij, Liutauras Juska, Justas Dapkunas, Andrius Sazonovas, Pranas Japertas and Remigijus Didziapetris, of ACD/Labs and Vilnius University
The FDA guidance for industry states impurities under the ICH threshold may be exaluated for genotoxicity and carcinogenicity. This study uses an expert system to detect mutagens and compounds labeled as potent carcinogens by the FDA.
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