|Comparison of Three Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development|
Gary dos Santos and Emer Clarke
Objective: To identify an assay that can accurately predict the risk of CRS and CS associated with investigational biotherapeutics. A comparison of three methods were used: (a) immobilization of test antibody on plastic, (b) co-culture of PBMC's on HUVEC's and (c) pre-culture of PBMC's at high cell density.
|Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements|
Sarah E. Voelker, M.S.; Travis M. Falconer, Ph.D.; Jonathan J. Litzau; Mary B. Jones; Lisa M. Lorenz
A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.
|A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies|
Hilary Brown, Jennifer Speer, John Gerling, and Kenyon Evans-Nguyen
Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.
|Combining low and high volume liquid handling capabilities for ADME screening|
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk
In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.
|Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles|
Syed Kashif Zafar, Syed Tarique Moin and Zaheer-ul-Haq
MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.
|Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison|
M.M. Rahman, B. S. Mohsina, K.M. Sharif, B. Y. Kamaruzzaman, M. B. Awang
Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.
|Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies|
Dos Santos G, Mergaert A and Clarke E.
This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.
|High-Throughput Analysis of DNA Samples using the D1K ScreenTape Assay and the Agilent 2200 TapeStation System|
Arunkumar Padmanaban, Ruediger Salowsky, Adam Inche
Recent advances in genomics demands to look at a wealth of genetic information in a short period of time. DNA analysis using slab gel electrophoresis and capillary electrophoresis are widely being used as a QC step in next generation sequencing and microarray studies. However, often these techniques lack the speed and involve more manual steps to perform the assay.
|Novel Antimalarial Drug Candidates Generated In Silico by Analysis of Public HTS Data|
Robert Fraczkiewicz, Michael S. Lawless, Robert D. Clark, and Walter S. Woltosz
This research aims to provide proof-in-principle that in silico tools could be applied to public data so as to efficiently identify active chemistry with good ADMET properties.
|Novel, Fully Automated Method Allows Efficient Analysis of qPCR Data for Qualitative Calling Based on Comparative Cq|
Collaborative research by Pioneer Hi-Bred (a DuPont company) and Azure PCR Limited
Assessment to ascertain if a method for analysis of qPCR data dependent on manual intervention can be replaced by automated analysis using the AzurePCRTM method.
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