Corporate Banner
Satellite Banner
Forensic Science & Clinical Toxicology
Scientific Community
 
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Identifying People Using Human Hair Proteins
In an important breakthrough for the forensic science community, researchers have developed the first-ever biological identification method that exploits the information encoded in proteins of human hair.
Origin of Cultured Cells: Not Where You Think
Study shows cultured cells from decades-old cell line does not originate from the patient it was claimed to derive from.
Bringing NGS to the Crime Lab
New technology being validated in BCI lab for use in Ohio missing persons cases.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Detecting Drug Use in Hair
Scientists at Wageningen UR have developed a faster and more accurate method for the detection of drug use using hair.
Eliminating Doubt in Criminal Investigations
New ASU certificate to help curb error, misunderstanding in the quest for justice.
Determination of 13 Organic Toxicants in Human Blood
Researchers have utilised liquid-liquid extraction coupling HPLC-MS/MS to identify and quantify organic toxicants in human blood.
A Novel Cell Culture Model For Forensic Biology Experiments
Researchers have developed a new cell culture model which provides an efficient research tool in forensic biology.
Rhino DNA Bank Aids Anti-Poaching Fight
At the University of Pretoria's Veterinary Genetics Laboratory (VGL) at Onderstepoort, Dr Cindy Harper and her team have developed a ground-breaking technique to collect and catalogue DNA from rhinos and rhino horns.
Gender Determination in Forensic Investigations
This study investigated the effectiveness of lip print analysis as a tool in gender determination.
Scroll Up
Scroll Down

A Complete Forensic Toxicology Screening Procedure for Drugs and Toxic Compounds in Urine and Plasma Using LC-MS/MS
Bookmark and Share

Thermo Scientific

Introduction
Forensic toxicology laboratories commonly use automated immunoassays, gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography-diode array detector (HPLC-DAD) techniques to perform toxicology screening analyses. None of these techniques are able to identify all the drugs and toxic compounds that are potentially present in a sample. Implementation of liquid chromatography-mass spectrometry (LC-MS) for forensic toxicology screening provides specific and sensitive analysis of drugs and toxic substances. The benefits of the LC-MS/MS screening methodology include a simple sample preparation procedure, ease of adding new compounds to the screening method and fewer limitations based on compound volatility and thermal stability. In addition, Thermo Scientific ToxID automated toxicology screening software is able to automatically generate both Summary and Long Reports, avoiding the need for manual analysis of each sample chromatogram. This application note describes the use of the Thermo Scientific LXQ ion trap mass spectrometer equipped with an ESI source and HPLC for identification of unknown compounds in urine and plasma for clinical research and forensics.

Further Information

Related Content

Thermo Scientific at ASMS 2013
Learn how scientists and researchers are transforming science by applying innovative solutions to a wide range of qualitative and quantitative applications.
Monday, May 13, 2013
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!