Evaluation of Candidate Reference Genes for Gene Expression Normalization
Study performed in Brassica juncea using real time quantitative RT-PCR.

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Reliable and Rapid Characterization of Functional FCN2 Gene Variants Reveals Diverse Geographical Patterns
In this study, scientists genotyped and characterized four FCN2 functional SNP variants in West Africans, South Americans, South East Asians from Vietnam and Caucasians from Germany using an available rapid, reliable and cost effective FRET-RTPCR methodology.

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Good News for Nanomedicine
Quantum dots appear safe in pioneering study on primates.

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Research on Butterflies Reveals Genetic Sharing
Landmark effort to sequence the genome of a South American butterfly has revealed the key behind its ability to mimic other butterflies.

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Zooming in on Early Embryonic Development
Broad Institute researchers show a high-resolution view of mouse embryogenesis, down to individual bases, showing genetic changes.

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New Technique Reveals Unseen Information in DNA Code
Scientists have developed and tested a technique to distinguish between two modified forms of cytosine.

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NIH Study Finds that Coffee Drinkers have Lower Risk of Death
Older adults who drank coffee — caffeinated or decaffeinated — had a lower risk of death overall than others who did not drink coffee.

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Finnish Researchers Discover Genes Inhibiting the Spread of Prostate Cancer
Researchers utilize the cell spot micro array technology to study the impacts of all genes in an entire genome in a single experiment.

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Stabilizing Fanconi Anemia with Antioxidants
Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000.

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Scientists Make Groundbreaking Discovery Of Mutation Causing Genetic Disorder In Humans
Scientists at A*STAR's Institute of Medical Biology (IMB), in collaboration with doctors and scientists in Jordan, Turkey, Switzerland and USA, have identified the genetic cause of a birth defect known as Hamamy syndrome.

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Debiopharm and Vifor Pharma Sign an Exclusive Agreement
Distribution and commercialization of Pamorelin® LA in Switzerland.

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TTP Labtech will Showcase its Latest Automated Technology Innovations in Europe
Delivering a wealth of new products to the attendees of ELA 2012.

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BioTime Completes Merger of XenneX, Inc. into LifeMap Sciences, Inc.
LifeMap Sciences now holds the exclusive, worldwide licenses to market GeneCards(R) and PanDaTox from Yeda Research and Development Company Ltd.

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Agilent to Acquire Dako for $2.2 Billion
The largest acquisition in Agilent’s history is the next step in their growing role in clinical diagnostics.

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Affymetrix and ScreenCell Announce Worldwide Distribution Agreement for CTC Technology
Combination of ScreenCell’s isolation devices and Affymetrix’ QuantiGene® ViewRNA ISH technology enables easy, accessible, sensitive, multiplex, low-cost system to enumerate and characterize CTCs and other rare cells.

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OpGen Announces Formation of Public Health Consortium
Consortium to evaluate whole genome mapping for improved genetic analysis of disease outbreaks.

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Affymetrix and ScreenCell Announce Worldwide Distribution Agreement
Affymetrix releases first circulating tumour cell platform technology for 4-color RNA-ISH.

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Epizyme Announces Appoint Chief Medical Officer
Dr. Eric Hedrick has joins the personalized therapeutics company as Chief Medical Officer.

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Partnership Provides Processing and Scale-up for AAV Vectors
Avalanche Biotechnologies, Inc. and Lonza announce global manufacturing collaborate for adeno-associated viral vectors for gene therapy.

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Plexpress Announces Collaboration with Admescope
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.

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Volume-Related Inhibitors Standardization for Reverse Transcription Quantitative Polymerase Chain Reaction Experiments
IRBA

This poster addresses the reliability of qPCR data and its dependence on technical variations. The proposal is that constant volume of RNA extract in order to improve reliability.

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Defining off-target cleavage in a pair of Zinc Finger Nucleases
University of Utah

This study looks at off-target cleavage of Zinc Finger Nucleases (ZNFs) in Drosophila in an attempt to analyze potential cleavage spots, with a view to designing more efficient ZFNs.

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Gene Expression Profiling: qPCR Toolkit for Quality Control
TATAA Biocenter

TATAA Biocenter explain how they developedand optimized high-throughput gene expression qPCR with ValidPrime quality control, compensating for inter-run variations.

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Cytotoxicity Screen of Mangiferin and its Major Metabolite Norathyriol in Human Tumor Cell Lines
DKFZ

Many natural products are available worldwide as potential chemoprotective agents against commonly occurring cancers, for example Mangiferin which has low bioavailability and is thought to be mainly available in the colon.

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Polarized Cell Expansion and Heterochronic Shift in Angiosperm Spermatogenesis
UEB

This study evaluates genetic factors and common pathways in polarized cell-tip expansion.

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Identification and Characterisation of Disease Resistance Pathway Genes in Jute (Corchorus spp.)
Plant Molecular Biology Laboratory, University of Dhaka, Bangladesh

Study aims include identification and characterisation of all NBS containing genes in jute using degenerate primers designed from the conserved NBS domain, by using two species of jute; susceptible and wild type resistant varieties.

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Effect of Liquid Handling Quality Control on Biological Assay Performance
Biomanufacturing Training and Education Center

High quality assays are required in order to take forward potential drugs, post screening. Therefore the liquid handling must be accurate and precise, as demonstrated in this experiment.

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Why Is My Assay Failing? An Approach to Assay Equipment Optimization
Artel

Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process.

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An Automated, Cell-based Platform for the Rapid Detection of Novel Androgen Receptor Modulators
BioTek Instruments

The Androgen Receptor (AR) is a member of the family of nuclear receptors responsive to steroid hormones. This poster aims to devise, validate and perform a preliminary automated HTS screening campaign to identify novel modulators of AR activity.

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Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments

Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.

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Automation of a Generic Fluorescent Methyltransferase Activity Assay
BioTek Instruments

The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.

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Performance Qualification of an Automated Plate Washer Using the Artel MVS®
Artel

The purpose of this application note is to demonstrate the ability of the MVS® Multichannel Verification System to test the performance of an automated plate washer. The previously written application notes, Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach1 will be cited within as these unique applications relate to this discussion involving tests for (1) bulk dispense precision and accuracy and (2) volume evacuation efficiency.

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Using the MVS to Measure Residual Volumes Remaining in a Plate After Sample Aspiration: General Approach
Artel

The purpose of this application note is to demonstrate an alternative use for the Artel MVS® Multichannel Verification System. As opposed to measuring the accuracy and precision for a volume transfer of sample into a microtiter plate, the MVS is instead used to measure resididual liquid after sample is aspirated out of each well.

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Artel MVS as a Tool For Measuring Liquid Mixing Efficacy in Microplates
Artel

This application note describes how the ARTEL MVS® Multichannel Verification System can be used as a tool for measuring the efficacy of liquid mixing protocols.

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Evaluation of Forward and Reverse Mode Liquid Handling Techniques Using the ARTEL MVS®
Artel

This study illustrates the use of the Artel MVS® Multichannel Verification System to rapidly evaluate the accuracy and precision of dispensed volumes from the Caliper RapidPlate liquid handler.

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Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.

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Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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Overcoming the Challenge of Reliable Multi-way Fluidic Connections
Dolomite

If you are struggling to create fast and reliable microfluidic connections, Multiflux™ may be the solution you are looking for.

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DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.

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