Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Bioo Scientific Awarded SBIR Grant for Development of Targeted RNAi In Vivo Delivery Technology

Published: Wednesday, July 29, 2009
Last Updated: Wednesday, July 29, 2009
Bookmark and Share
A $500,000 Phase II grant will help to develop kits and reagents based on the patent-pending Targeted Transport Technology.

Bioo Scientific has announced that it has been awarded a $500,000 Small Business Innovation Research (SBIR) Phase II grant from the National Science Foundation for the development of a targeted in vivo RNA Interference (RNAi) delivery technology.

RNAi is an invaluable technique to characterize gene function and is being evaluated for the treatment of numerous human diseases.

According to Lance Ford, Bioo Scientific’s VP of Research and Business Development, “While technologies are widely available for RNAi agent delivery into cells grown on plastic dishes in specially designed incubators, to fully understand gene functions and cellular pathways, in vitro results must be validated in animals. Currently, there are no commercial technologies for the targeted, in vivo delivery of RNAi agents and Bioo Scientific intends to fill this gap”. This grant will enable Bioo Scientific to develop kits and reagents based on the patent-pending Targeted Transport Technology (T3).

T3 involves conjugating an RNAi agent carrier to a monoclonal antibody (mAb) to produce a conjugate, which is then loaded with an RNAi agent such as siRNA and miRNA molecules. The RNAi agent loaded conjugate is administered to an animal where it binds to and is internalized by cells recognized by the mAb. The RNAi agent is then released to reduce the expression of its intended target. T3 will propel the validation of animal experimentation, leading to a better understanding of cellular pathways, the identification of novel drug targets, and the ability to more efficiently deliver RNAi agents as drugs.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Bioo Scientific Awarded $750,000 NSF Grant
Company awarded a National Science Foundation Phase II grant to continue development efforts to improve the accuracy of small RNA expression analysis.
Wednesday, November 26, 2014
Bioo Scientific Receives Presidential Award for Exports
Awards are the highest recognition any U.S. entity may receive for making a significant contribution to the expansion of U.S. exports.
Thursday, May 29, 2014
NSF Funds Research Partnership Between Bioo Scientific and Mirna Therapeutics
The funding will support tumor regression and pharmacokinetic studies on targeted delivery of microRNAs.
Thursday, July 22, 2010
Bioo Scientific Corp. Receives NIH Grant for the Development of Novel Anti-Viral Therapeutics
Researchers discover a mechanism by which several viruses suppress aspects of the cell to stabilize their nucleic acids to promote an efficient infection.
Tuesday, May 05, 2009
Custom RNA Interference Service
BIOO Scientific is launching a service to perform in vivo RNAi testing to facilitate progress in the drug pipeline.
Thursday, April 12, 2007
Scientific News
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
GMO Food Animals Should be Judged by Product, Not Process
In a world with a burgeoning demand for meat, milk and eggs, regulatory policies around the use of biotechnologies in agriculture need to be based on the safety and attributes of those foods rather than on the methods used to produce them, says a UC Davis animal scientist.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
Gene Drive Reversibility Introduces New Layer of Biosafety
Ability to introduce or reverse the spread of genetic traits through populations could one day improve pest management and disease control.
RNA-Based Drugs Give More Control Over Gene Editing
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos