Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

BGI and GT Life Sciences Announce Complete Sequencing of CHO Genome

Published: Monday, January 10, 2011
Last Updated: Monday, January 10, 2011
Bookmark and Share
CHO whole genome sequence data has been assembled and early access is now available.

GT Life Sciences, Inc., and BGI announced that they have successfully completed for the first time the sequencing of the Chinese hamster ovary (CHO-K1) genome. Early access to the genome is now available.

Chinese hamster ovary cell lines, or CHO cell lines, are mammalian cells that have been derived from the ovary of the Chinese hamster and are used widely in biological research and in the production of therapeutic proteins. Today at least 70% of all therapeutic proteins are produced in CHO cells.

Currently the worldwide market for therapeutic proteins totals approximately $100 billion. The sequencing of the CHO genome will yield a wealth of new information and understanding of CHO cell functions, accelerating the discovery and development of new recombinant protein therapeutics. By increasing the productivity of CHO cell lines used in many pharmaceutical expression systems, production costs can be reduced.

"Sequencing the CHO genome represents a major milestone in optimizing this widely used mammalian cell line both for pharmaceutical research and for production of therapeutic proteins," stated Bernhard Palsson, Ph.D., Galetti Professor of Bioengineering and Adjunct Professor Medicine at the University of California, San Diego. "This newly available knowledge will bring multiple benefits, including media optimization and improved cell growth, protein production, glycosylation, and cell line engineering. Ultimately, it brings genome-scale science to CHO-based production of biopharmaceuticals."

GT Life Sciences' established CHOmics business platform for metabolic modeling and engineering of mammalian cells has already proven effective in optimizing CHO cell media and developing novel selectable markers. "The availability of the sequence together with a complete genome-scale model of CHO metabolism is proving to be a powerful tool that will allow us to deliver the next generation of process technologies for biopharmaceutical production in CHO and other mammalian cell lines," added Iman Famili, Ph.D., Sr. Director, Research and Development at GT Life Sciences.

"The complete sequencing of CHO-K1 genome is a major step forward in the application of genomics in the production of biopharmaceuticals," stated Dr. Jun Wang, Executive Director of BGI. "GT's CHOmics platform provides a valuable foundation for CHO genomics research and the study of CHO cell metabolism. BGI's sequencing and bioinformatics capabilities, combined with GT's CHOmics platform, will contribute to the transformation of biopharmaceutical production."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

BGI Opens Genome Research Center in Europe
The company opens its first European Genome Research Center located in Copenhagen Bio Science Park (COBIS).
Friday, February 10, 2012
Scientists Complete Sequencing Tibetan Antelope Genome
The genome sequencing is expected to explain the pathogenesis of chronic plateau sickness.
Monday, December 28, 2009
Beijing Genomics Institute Signs Global Site License with CLC bio for Sequencing Software Platform
The global site license agreement, for CLC Genomics Workbench, covers all researchers at all BGI sites, both inside and outside of China.
Friday, July 04, 2008
Scientific News
“Sixth Sense” More Than a Feeling
NIH study of rare genetic disorder reveals importance of touch and body awareness.
A Diversity of Genomes
New DNA from understudied groups reveals modern genetic variation, ancient population shifts.
Gene Could Reduce Female Mosquitoes
Virginia Tech researchers have found a gene that can reduce female mosquitoes over many generations.
Improving Crop Efficiency with CRISPR
New study of CRISPR-Cas9 technology from Virginia Tech shows potential to improve crop efficiency.
Examining mtDNA May Help Identify Unknown Ancestry That Influences Breast Cancer Risk
Researchers studying mtDNA in a group of triple negative breast cancer patients found that 13 percent of participants were unaware of ancestry that could influence their risk of cancer.
Bacteria Use Ranking Strategy to Fight Off Viruses
Researchers have explained why microbes store virus confrontation information sequentially, with most recent attacks first.
Gene Therapy Technique May Help Prevent Cancer Metastasis
Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
The Genetics of Blood Pressure
Researchers have identifed areas of the genome associated with blood-pressure including 17 previously unknown loci.
Mosquito Genetics Determine Tastes
Study reveals mosuito's preference for human versus animal biting is determined by genetics.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!