Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Research Center to Focus on Mammalian Single Cell Genomics

Published: Friday, June 15, 2012
Last Updated: Friday, June 15, 2012
Bookmark and Share
New Center will feature a complete suite of Fluidigm single-cell tools, protocols and technologies.

The Broad Institute and Fluidigm Corporation have announced the launch of a new research center dedicated to accelerating the development of research methods and discoveries in mammalian single-cell genomics.

The Single-Cell Genomics Center is also expected to act as a hub for collaboration among single-cell genomics researchers in many pioneering fields, including stem cells and cancer biology.

The Center will be housed at the Broad Institute in Cambridge, Massachusetts and will feature a complete suite of Fluidigm single-cell tools, protocols and technologies, most notably the BioMark™ HD System.

The Center grew out of ongoing collaborations between the Broad Institute and Fluidigm that bridge multiple genomic platforms.

"With the Single-Cell Genomics Center, we will enable researchers to access the exciting new world of single-cell genomics, catalyze discoveries and advance our understanding of this important area of biology," said Wendy Winckler, Ph.D., Director of the Genetic Analysis Platform at the Broad Institute.

"The cell is the fundamental unit of life, and through greater understanding of it, researchers can make breakthroughs in large and important fields, such as cancer diagnosis and therapy, stem cell biology, vaccine development, and even the mounting battle against drug-resistant bacteria. We expect this center to inspire, enable and accelerate efforts in the emerging field of single-cell research," said Gajus Worthington, President and Chief Executive Officer of Fluidigm.

Researchers have long known that heterogeneity exists among cells in tissue samples and other populations, but this cellular variability is masked by averaging data across pooled cell samples.

The ability to tease out single-cell genomic data has historically been limited by a lack of standardized, user-friendly methods that would allow the broader biological and clinical communities to study individual cellular variability at high definition, high throughput, and low cost.

Advances in technology, such as Fluidigm's microfluidic chips and high-throughput instruments, have made single-cell studies feasible by converting cellular heterogeneity from a source of background noise to a source of information enabling cutting-edge discoveries.

Fluidigm's technology provides the capabilities required to analyze single cells: microfluidics and sensitivity at the nanoscale level; parallel processing of a large number of cells; and interrogation of a large number of gene targets.

This unique combination of technological capabilities has fueled an upsurge in single-cell research and propelled Fluidigm technology into a leadership position in supplying tools to single-cell genomic researchers.

Through this collaborative effort, the Center intends to develop novel single-cell, microfluidic approaches for gene expression profiling, RNA/DNA sequencing and epigenetic analysis.

The goal of these efforts is to make single-cell research accessible to the greater scientific community by developing and disseminating new workflows, reagents, bioinformatics tools, and data sets.

These advances will allow deeper exploration of the underlying causes of many diseases, including the progression of individual cancers, differential immune responses, and the maturation of stem cells.

"Our intent is to establish the Center as a focal point to enhance collaboration and accelerate the science, applications, methods and discoveries in single-cell genomics research," said Ken Livak, Ph.D., Fluidigm Senior Scientific Fellow, who will act as the Alliance Manager at the Broad Institute, overseeing research projects amongst the Center and project partners.

"Our efforts with the Broad Institute in forming a center that specifically focuses on single-cell research represent a big step forward for this emerging area of biological research," Livak concluded.

Fluidigm equipment is currently being installed at the Center and first proposals for projects are being solicited from the Broad community of researchers. It is expected that the Single-Cell Genomics Center will become fully operational this quarter.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Revealing the Role of “Precocious” Dendritic Cells in Inflammatory Response
Discovery makes it possible for researchers to explore how these “precocious” cells escalate the body’s immune response when the body is under attack.
Monday, July 07, 2014
Fluidigm to Acquire DVS Sciences
The acquisition consideration of approximately $207.5 million consists of a combination of Fluidigm common stock and cash.
Wednesday, January 29, 2014
Fluidigm Reports Strong Q1 2013 Results
Revenue up 33% and margins increase 300 basis points compared to Q1 2012.
Friday, May 03, 2013
Singapore Single-Cell Research Centre Opens Door for Asian Biological Discoveries
Centre dedicated to diagnosis and treatment derived from single-cell exploration.
Monday, April 29, 2013
Fluidigm Reports Financial Results for First Quarter 2012
Q1 total revenue up 26% compared to Q1 2011.
Monday, May 14, 2012
Fluidigm Announce Israeli Distribution Deal
Fluidigm has appointed Eisenberg Brothers as distributor in Israel and Eisenberg Brothers offers Fluidigm's complete portfolio of BioMark™, EP1™, and Access Array™ systems.
Tuesday, March 01, 2011
Leading Leukemia Lab Invests In Fluidigm Access Array™ and EP1™ Systems
Fluidigm Corporation has announced that MLL Munich Leukemia Laboratory (www.mll.com) has purchased Access Array™ and EP1™ Systems.
Tuesday, November 16, 2010
Research Newsletter for Biochip User Community
Fluidigm announces availability of the Fall 2010 edition of its community newsletter.
Tuesday, October 19, 2010
Fluidigm Europe Announces a new Technical Poster Describing its Access Array™ Chip Technology
New poster describes how Access Array™ chip technology has been used at NCI’s core facility to capture and sequence the entire EBV genome.
Friday, August 13, 2010
Leading Agricultural Institute Reports Robust Genetic Analysis Results from Fluidigm Biomark™ System
INRA core facility is now providing a wide range of services on a Fluidigm BioMark™ System for Genetic Analysis to all European researchers.
Thursday, July 22, 2010
Modelling the Genetic Circuitry of Cell-to-Cell Communication
Stanford researchers used Fluidigm support instrumentation for analysis and modeling on how biological systems operate at the cellular level.
Thursday, July 15, 2010
Fluidigm Announces Availability of its Summer 2010 Edition of ‘IFC Application Hotspot’ E-newsletter
Issue includes two customer application studies, a recorded video interview with the GIS and a new single-cell gene expression protocol.
Friday, July 09, 2010
Fred Walder Joins Fluidigm as Chief Business Officer
Senior Executive from Fortune 500 company to lead business development and marketing for integrated fluidic circuit inventor.
Wednesday, June 30, 2010
Pathway-Focused Gene Expression Panels Validated for Real-time PCR
Fluidigm and SABiosciences team up to create gene expression panels validated for real-time PCR analysis on the Fluidigm BioMark™ System.
Thursday, April 08, 2010
USDA Purchases Fluidigm Solution for Development and Validation Testing of Cattle SNP Panels
Fluidigm’s EP1™ System will develop and validate focused 96- and 384-SNP panels for testing America’s dairy and beef cattle.
Friday, January 08, 2010
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Searching Big Data Faster
Theoretical analysis could expand applications of accelerated searching in biology, other fields.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!