Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

DNA Variants Explain Over 10% of Inherited Genetic Risk for Heart Disease

Published: Monday, November 12, 2012
Last Updated: Monday, November 12, 2012
Bookmark and Share
About 10.6% of the inherited genetic risk for developing coronary artery disease (CAD) can be explained by specific DNA variations.

The research, conducted by scientists in the CARDIoGRAMplusC4D consortium, pinpointed 20 previously unidentified mutations during a two-stage meta-analysis of 63,746 patients with CAD, which causes more deaths worldwide than any other disease.

These genetic variants generally were infrequently found in the DNA of the 130,681 individuals without heart disease who were in the control group.

The new mutations have boosted to 47 the total number of DNA variants that have thus far been linked to an increased risk for developing CAD, said Panos Deloukas, Ph.D., who co-led the study and heads the Genetics of Complex Traits in Humans research group at the Wellcome Trust Sanger Institute, Cambridge, UK.

Scientists had previously estimated that 30 to 60% of the variation in CAD might be attributable to genetic risk factors, according to a study published in 2005*. The research reported at ASHG 2012 expands the number of specific genes that are likely involved.

"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person’s risk for the disease,” said Dr. Deloukas. “Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk.”

Aravinda Chakravarti, Ph.D., professor of medicine, pediatrics and molecular biology and genetics at Johns Hopkins University’s McKusick-Nathans Institute of Genetic Medicine, who was not involved in conducting the study, commented, “Large genetic epidemiological studies, such as the one by CARDIoGRAM, have become critical for defining the specific loci that are major contributors to coronary artery disease. Although the specific genes and their variants that lead to susceptibility need to be discovered the current study is exciting in suggesting lipid levels and inflammation as key biological risk factors. These pathophysiological hypotheses demonstrate that we can understand complex diseases from comprehensive studies."

Identifying the genetic mutations that set the stage for CAD enables researchers to investigate the underlying mechanisms of the disease, which may lead to therapeutic targeting through drugs, Dr. Deloukas said.

Many of the newly identified variations are in genes that operate in biological pathways involved in the body’s metabolism of lipids or fats as well as in inflammation. The build-up of fatty cholesterol-rich plaque in blood vessels, a classic feature of CAD, not only can impair blood circulation but also can unleash the clots that obstruct blood flow to the heart and thereby cause heart attacks.

“Exactly how inflammation plays a role in heart attack remains a topic of ongoing research,” said Dr. Deloukas, adding that the consortium’s findings underscore the roles of high cholesterol levels and inflammation in CAD.

The researchers’ presentation is titled, “Coronary artery disease loci identified in over 190,000 individuals implicate lipid metabolism and inflammation as key causal pathways; evidence for independent signals in many of the risk loci.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

ASHG, The Jackson Laboratory Launch Educational Collaboration
New programs aim to integrate genetics and genomics into medicine.
Friday, June 13, 2014
New Method Helps Link Genomic Variation to Protein Production
Research presented at American Society of Human Genetics 2012.
Friday, November 09, 2012
Scientific News
New CAR T Cell Therapy Using Double Target Aimed at Solid Tumors
Researchers at Penn University have described how antibody, carbohydrate combination could apply to range of cancer types.
Erasing Unpleasant Memories with a Genetic Switch
Researchers from KU Leuven and the Leibniz Institute for Neurobiology have managed to erase unpleasant memories in mice using a 'genetic switch'.
New Method Detects Telomere Length for Research into Cancer, Aging
UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.
Assessing the Effectiveness of Genome-Editing Technologies
Researchers have developed a cost-effective and rapid method for assessing edits generated by CRISPR-Cas9 and other genome-editing technologies.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Alzheimer's Genetics Point To New Research Direction
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!