Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Research Identifies a Genetic Cause of Hypertension

Published: Thursday, November 22, 2012
Last Updated: Thursday, November 22, 2012
Bookmark and Share
A multinational research project led by the Universities of Dundee and Glasgow has identified a genetic determinant of hypertension, which could inform treatment of the condition for thousands of patients.

Hypertension (high blood pressure) is a commonly inherited condition arising from the interplay between genetic factors and the environment. However, the genes underlying this have proved difficult to identify.
 
This new research has identified a common mutation of the genes which regulate the production of the essential hormones - aldosterone and cortisol - in the adrenal gland as being influential in the development of hypertension.
 
“It has proved very difficult to identify genetic causes of hypertension but this research shows that a gene variation that is present in around 40% of the population is a significant factor,” said Professor John Connell, Vice-Principal of the University of Dundee, who led the project.
 
“Drugs targeting aldosterone are already used in the treatment of hypertension, so this study emphasises that these should be more widely used. It will also inform the development of other therapies that could affect the way that aldosterone is produced.  We know that the effects of aldosterone are amplified by a high salt diet, so this could give an important clue to an interaction between a common genetic variation and the environment.”
 
The project was funded by the Medical Research Council, and led by Professor Connell (University of Dundee) and Professor Eleanor Davies (University of Glasgow), in collaboration with partners across the UK and Europe including the Universities of Cambridge, Aberdeen, Queen Mary London, Oxford and Leicester.
 
The results of the research have been published online by Hypertension, the journal of the American Heart Association.
 
The study utilised data on more than 3000 patients held by the MRC British Genetics of HyperTension (BRIGHT) study and a further 2900 cases from the Nordic Diltiazem study (NORDIL) and the Malmo Cancer and Diet Study.
 
The study built on theoretical models that variations in these genes may be risk factors for hypertension. “One of the extremely satisfying aspects of this research has been that we have been able to take that theory all the way through to firm findings that show how the gene variation leads to altered function,” said Professor Davies.
 
Professor Connell said “We will now look to carry out further research, particularly with regard to the importance of genetically determined variation in aldosterone in other forms of cardiovascular disease.”
 
To view the full paper see:
http://hyper.ahajournals.org/content/early/2012/11/12/HYPERTENSIONAHA.112.200741.abstract.html?ijkey=ZioqEzXNq0LGIpM&keytype=ref


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New CAR T Cell Therapy Using Double Target Aimed at Solid Tumors
Researchers at Penn University have described how antibody, carbohydrate combination could apply to range of cancer types.
Erasing Unpleasant Memories with a Genetic Switch
Researchers from KU Leuven and the Leibniz Institute for Neurobiology have managed to erase unpleasant memories in mice using a 'genetic switch'.
New Method Detects Telomere Length for Research into Cancer, Aging
UT Southwestern Medical Center cell biologists have identified a new method for determining the length of telomeres, the endcaps of chromosomes, which can influence cancer progression and aging.
Assessing the Effectiveness of Genome-Editing Technologies
Researchers have developed a cost-effective and rapid method for assessing edits generated by CRISPR-Cas9 and other genome-editing technologies.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Alzheimer's Genetics Point To New Research Direction
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Contagious Cancers Are Spreading in Shellfish
Direct transmission of cancer among some marine animals may be more common than once thought, suggests a new study published in Nature by researchers at Columbia University Medical Center (CUMC).
Fix for 3-Billion-Year-Old Genetic Error
Researchers at The University of Texas at Austin have developed a fix that allows RNA to accurately proofread for the first time.
Higher Frequency of Huntington's Disease Mutations Discovered
University of Aberdeen study shows that the gene change that causes Huntington's disease is much more common than previously thought.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!