Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

MiReven Announces Positive In Vitro Results for miRNA-7-5p in Melanoma

Published: Tuesday, February 12, 2013
Last Updated: Monday, February 11, 2013
Bookmark and Share
MiReven launches its new website at www.mireven.com.au.

MiReven has announced the publication in the journal Biochemical and Biophysical Research Communications of an in vitro study where the microRNA “miR-7-5p” significantly inhibited the migration and invasion of metastatic melanoma cells.

At the same time MiReven is launching its new corporate website, which can be viewed at: www.MiReven.com.au.

MicroRNAs (miRNAs) - non-coding regulatory RNA molecules with altered expression and function in cancer - have both oncogenic and tumor suppressor potential.

While the function of many miRNAs in melanoma remains unclear, several recent reports have implicated specific miRNAs, including miR-7-5p, in the progression to metastatic disease.

In the study, miR-7-5p expression was shown to be reduced in metastatic melanoma-derived cell lines compared with primary melanoma cells.

When the microRNA was reintroduced and expressed ectopically, migration and invasion of the melanoma cells was significantly inhibited in vitro.

The study authors also investigated the mechanism of miR-7-5p and found that insulin receptor substrate-2 (IRS-2) is a functional target of miR-7-5p which then decreases activity in the protein kinase B (Akt) signaling pathway, a key regulator of many oncogenic processes including cell migration.

Dr Keith Giles and Professor Peter Leedman from the WAIMR, who led the study, explained: “There is considerable interest in the molecular pathogenesis of malignant melanoma and a focus on finding ways to improve survival of patients with metastatic disease. Our study shows that miR-7-5p may represent a novel therapeutic approach to prevent or limit melanoma metastasis.”

Dr Stephen Thompson, Chairman of MiReven Pty Ltd, said: “This now published study is one of several in press or already published demonstrating the utility of microRNAs in the treatment of cancer. Alongside antibodies and small molecule inhibitors, a picture is emerging where microRNAs offer a new direction for cancer therapeutic interventions. Specifically, this study shows that miR-7 acts on other pathways in cancer beyond EGFR.”

The study was published in the peer reviewed journal Biochemical and Biophysical Research Communications (Volume 430, Issue 2, Pages 706-710) and is entitled “miRNA-7-5p Inhibits Melanoma Cell Migration and Invasion” by Keith M. Giles, Rikki A.M. Brown, Michael R. Epis, Felicity C. Kalinowski and Peter J. Leedman.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
How Scientists Use DNA to Track Disease Outbreaks
They’re the top questions on everyone’s mind when a new disease outbreak happens: where did the virus come from? When did this happen? How long has it been spreading in a particular country or group of people?
Genetic Risk Factors of Disparate Diseases Share Similar Biological Underpinnings
Penn Institute for Biomedical Informatics and colleagues identify "roadmap" of disease mechanisms to identify candidate drug targets.
Stem Cells Know How to Unwind
Research led by the Babraham Institute with collaborators in the UK, Canada and Japan has revealed a new understanding of how an open genome structure supports the long-term and unrestricted developmental potential in embryonic stem cells.
Childhood Asthma Research Receives $2M
Research into the impact of a child’s upbringing and social and physical environments on the development of asthma will receive $2 million to tackle the condition that affects as many as one in three Canadians.
Five New Breast Cancer Genes Found
Discovery of mutations paves the way for personalised treatment of breast cancer.
Cell Transplant Treats Parkinson’s in Mice
A University of Wisconsin—Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell.
Understanding Female HIV Transmission
Glowing virus maps points of entry through entire female reproductive tract for first time.
Genetic Markers Influence Addiction
Differences in vulnerability to cocaine addiction and relapse linked to both inherited traits and epigenetics, U-M researchers find.
A lncRNA Regulates Repair of DNA Breaks in Breast Cancer Cells
Findings give "new insight" into biology of tough-to-treat breast cancer.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!