Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Lack of Sleep Alters Human Gene Activity

Published: Thursday, February 28, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
New research from the University of Surrey has found that as little as one week of inadequate sleep is enough to alter the activity of hundreds of human genes.

The BBSRC-funded research monitored the activity of all genes of the human genome and found that inadequate sleep (less than six hours a night) affects the activity of over 700 of our genes. These included genes which are linked to controlling inflammation, immunity, and the response to stress.

Furthermore, the research shows that inadequate sleep reduced the number of genes that normally peak and wane in expression throughout the 24-hour day from 1,855 to 1,481. The authors found that the number of genes affected by sleep deprivation was seven times higher after a week of insufficient sleep.

Sleep deficiency leads to a host of significant health conditions including obesity, heart disease, and cognitive impairment, but until now scientists were unclear how gene expression patterns were altered by insufficient sleep. These 'gene expression' patterns provide important clues on the potential molecular mechanisms linking sleep and overall health.

Derk-Jan Dijk, Director of the Sleep Research Centre at the University of Surrey, which receives funding from BBSRC, said: "This research has helped us to understand the effects of insufficient sleep on gene expression. Now that we have identified these effects we can use this information to further investigate the links between gene expression and overall health."

The research was conducted by an interdisciplinary team of researchers consisting of physiologists, sleep and circadian rhythm experts and experts in functional genomics and bioinformatics.

Colin Smith, Professor of functional genomics at the University of Surrey says: "The current interest in sleep and circadian rhythms as determinants of health and disease is a vital area of research. By combining our expertise in sleep and 'genomics' (the study of the full complement of our genes), we are starting to make breakthroughs that will have an impact on our understanding and treatment of poor health arising from insufficient sleep."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genome-Editing Position Statement
A group of leading UK research organisations has today issued an initial joint statement in support of the continued use of CRISPR-Cas9 and other genome-editing techniques in preclinical research.
Monday, September 07, 2015
Expanding the DNA Alphabet: 'Extra' DNA Base Found to be Stable in Mammals
A rare DNA base, previously thought to be a temporary modification, has been shown to be stable in mammalian DNA, suggesting that it plays a key role in cellular function.
Thursday, June 25, 2015
Researchers Use ‘Big Data’ Approach to Map the Relationships Between Human and Animal Diseases
EID2 database used to prevent and tackle disease outbreaks around the globe.
Thursday, July 17, 2014
TGAC at the Forefront of Next Generation Sequencing Capability
The Genome Analysis Centre adds two Illumina HiSeq 2500 machines to its platform suite.
Thursday, June 26, 2014
£12M for Synthetic Biology Facilities and Training
The UK Research Councils, led by the BBSRC, will award £10M to establish five centres for DNA synthesis across the UK to further develop the UK's research base in synthetic biology.
Monday, April 07, 2014
Scientists identify ‘long distance scanner’ for DNA damage
BBSRC-funded scientists at the University of Bristol have discovered that a mechanism for preventing mutation within important genes involves long distance scanning of DNA by a molecular motor protein.
Wednesday, February 26, 2014
UK Establishes Three New Synthetic Biology Research Centres
Bristol, Nottingham and a Cambridge/Norwich partnership will be UK centres for synthetic biology.
Friday, January 31, 2014
New Chromosome Map Points the Way Through Campylobacter’s Genetic Controls
The Institute of Food Research has produced a new map of the Campylobacter genome, showing the points where all of this pathogenic bacteria's genes are turned on.
Wednesday, November 13, 2013
BBSRC Invests £10 M in Synthetic Biology
The investment has been allocated to the fund by the BBSRC in response to the 2012 Synthetic Biology Roadmap, which sets out plans to harness opportunities in this area.
Thursday, November 07, 2013
A Community Based Approach for Tackling the Post-Genomic Data Deluge
Correspondence highlights the benefits of a community approach to gathering data that can help improve our understanding of the functions of genes.
Monday, October 14, 2013
‘X-Shape’ Not True Picture of Chromosome Structure, New Imaging Technique Reveals
First 3D pictures of chromosome structure revealed.
Friday, September 27, 2013
Moving Genes have Scientists Seeing Spots
An international team of scientists has perfected a way of watching genes move within a living plant cell.
Wednesday, September 11, 2013
Advance in Understanding Genome Reproduction
Researchers have provided new insight into how chromosome integrity is threatened each time a cell grows and divides, helping to underpin our knowledge of healthy aging.
Thursday, August 01, 2013
£60,000 Competition to Recognise Innovative Scientists Launched by BBSRC
Innovator of the Year 2014 competition launched by BBSRC to recognise and reward scientist's whose excellent science and innovations are delivering real world impact.
Friday, July 12, 2013
Babraham Scientists Establish Cancer-Focussed Collaboration with AstraZeneca
Partnership aims to advance cancer research and develop and evaluate new therapeutic strategies to tackle prostate and pancreatic cancers.
Wednesday, July 10, 2013
Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos