Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Study Shows Why Leukemia Returns in Some Children

Published: Thursday, February 28, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
With sophisticated new DNA techniques, a team of researchers has found, for the first time, why many children with a type of leukemia suffer a relapse.

The researchers found that about 20 percent of children with T-cell acute lymphoblastic leukemia (T-ALL) who experience a relapse harbor mutations that activate NT5C2, an enzyme that inactivates an important chemotherapy drug, 6-mercaptopurine (6-MP).

The discovery may soon lead to improved treatment for patients. “The most immediate thing to do now is to develop diagnostic tools,” said Ferrando, professor of Pediatrics and of Pathology & Cell Biology in the Herbert Irving Comprehensive Cancer Center.

“With diagnostic tools, we could monitor for this mutation and if we see it, these patients should probably receive a different drug.”

About one in five children with T-ALL will suffer a relapse, and despite intensive chemotherapy, most of these children will die from the disease.

Based on his findings, Ferrando said relapsed patients with the mutated enzyme could be switched to a new drug, nelarabine, that’s very similar to 6-MP. The researchers found that even though the two drugs act similarly, they are different chemically, and nelarabine is not affected by the mutated enzyme.

Full findings of the research were published Feb. 3 in Nature Medicine.

The mutated enzyme also was discovered independently in a New York University study of patients with the B-cell form of ALL.

In a New York Genome Center article about both studies, the leader of the NYU study, William Carroll, MD, said

“I think for those of us who treat leukemia, it is a really dramatic finding. Access to [patient] samples and new next-generation sequencing [give us a way] to really understand the blueprint of relapse and to develop specific therapies. We can individualize treatment.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Way to Identify Brain Tumor Aggressiveness
Looking at a brain tumor’s epigenetic signature may help guide therapy.
Friday, January 29, 2016
Link Between Congenital Heart, Brain Disorders
Tools of precision medicine may lead to earlier identification and treatment of children with neurodevelopmental disorders.
Thursday, December 10, 2015
DNA Abnormalities Found in Children with Chronic Kidney Disease
Routine genetic screening of children with CKD could lead to earlier, more precise diagnoses.
Tuesday, April 21, 2015
Patient-Specific Stem Cells and Personalized Gene Therapy
Patients’ own cells transformed into model for studying disease and developing potential treatment.
Saturday, July 12, 2014
Global Study Discovers Flurry of New Alzheimer’s Genes
An international study has uncovered 11 new genes that increase the chance of developing Alzheimer’s disease and provide new clues to ways of fighting it.
Wednesday, October 30, 2013
Test Could Identify Which Prostate Cancers Require Treatment
3-gene biomarker gauges tumor’s aggressiveness.
Thursday, September 12, 2013
Columbia Licenses Novel 3-D Organ and Tumor Segmentation Software to Varian Medical Systems
Allows for more precise and efficient planning and monitoring of cancer treatment.
Friday, May 17, 2013
Genes May Predict Response to Sole Sickle Cell Drug
Only one drug is currently available under FDA regulations, but response varies greatly from patient to patient.
Friday, February 22, 2013
Two Treatments for Retinitis Pigmentosa Move Closer to Clinical Trials
One treatment involves skin-derived induced pluripotent stem (iPS) cell grafts, the other gene therapy.
Friday, December 21, 2012
New Prenatal Gene Test Proposed as Standard of Care
Findings Published in NEJM show that microarray finds significantly more clinically relevant information than current method.
Thursday, December 06, 2012
Columbia Awarded One of First NCI “Provocative Questions” Grants
Timothy H. Bestor, PhD, an epigenetics researcher and professor of genetics and development at CUMC, was selected for his proposal, “Methylation Suicide in Cancer”.
Friday, September 21, 2012
DNA Repair: How Chromosomes Find Each Other
Study found that after a double-strand break in DNA, the mobility of both the broken segment and other, unbroken, chromosomes is greatly increased.
Wednesday, June 06, 2012
Scientific News
NIH Researchers Identify Striking Genomic Signature for Cancer
Institute has identified striking signature shared by five types of cancer.
CRI Develops Innovative Approach for Identifying Lung Cancer
Institute has developed innovative approach for identifying processes that fuel tumor growth in lung cancer patients.
The Spice of Life
Scientists discover important genetic source of human diversity.
Removing Race from Human Genetic Research
A group of scientists are urging their colleagues to take a step forward and stop using racial categories when researching and studying human genetics.
Tick Genome Reveals Secrets of a Successful Bloodsucker
NIH-funded study could lead to new tick control methods.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Switch Lets Salmonella Fight, Evade Immune System
Researchers at the University of Illinois at Chicago have discovered a molecular regulator that allows salmonella bacteria to switch from actively causing disease to lurking in a chronic but asymptomatic state called a biofilm.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!