Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Yeast Study Yields Potential for New Cholesterol, Anti-Fungal Drugs

Published: Thursday, February 28, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
While studying a mutant strain of yeast, Purdue University researchers may have found a new target for drugs to combat cholesterol and fungal diseases.

Scott Briggs, an associate professor of biochemistry, and Paul South, a postdoctoral researcher, were looking at how histones, the proteins that DNA wraps itself around, are affected by environmental factors, a field called epigenetics. When histones are modified, they change how genes are expressed and how cells behave.

One of the research team's yeast mutants lacks a methyltransferase called Set1, which is a protein that modifies histones. In this case, the lack of the methyltransferase decreases the amount of ergosterol production. Ergosterol is the equivalent of human cholesterol, and the biological pathways that create ergosterol in yeast and cholesterol in humans are similar, with both being essential for cellular membrane formation and integrity.

"So, if we could actually design an inhibitor to this methyltransferase, we potentially could have another drug to lower cellular cholesterol or one that could work in conjunction with current cholesterol-lowering drugs," said Briggs, whose findings were published in the Proceedings of the National Academy of Sciences.

The same yeast mutant with decreased ergosterol production was particularly sensitive to an anti-fungal metabolite called Brefeldin A, a drug primarily used as a research tool to study protein transport in cells.

"If you don't have this methyltransferase, cells grow slower in the presence of this anti-fungal metabolite," South said. "That means that a drug that inhibits the methyltransferase could also be used as an anti-fungal drug and potentially be used as another tool to fight drug-resistant fungal infections."

Development of new anti-fungal drugs could help with difficult-to-treat fungal infections, such as the fungal meningitis outbreak last year from contaminated drugs linked with a Massachusetts compounding pharmacy.

Briggs and South are now studying whether the yeast mutant that is more sensitive to Brefeldin A would be more susceptible to other clinically relevant anti-fungal drugs.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Mass Spectrometry Tool Helps Guide Brain Cancer Surgery
A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.
Wednesday, July 02, 2014
Helping Genes Get Out of the Starting Blocks Faster
Yeast can quickly adapt to changes in its environment with the help of molecules known as long non-coding RNAs, a Purdue study shows.
Friday, February 21, 2014
Cell-Detection System Promising for Medical Research, Diagnostics
Researchers are developing a system that uses tiny magnetic beads to quickly detect rare types of cancer cells circulating in a patient's blood.
Thursday, October 03, 2013
Purdue Innovation could Improve Personalized Cancer-Care Outcomes
An innovation could improve therapy selection for personalized cancer care by helping specialists better identify the most effective drug treatment combinations for patients.
Friday, August 16, 2013
Nanoparticles, 'pH Phoresis' Could Improve Cancer Drug Delivery
Researchers have developed a concept to potentially improve delivery of drugs for cancer treatment using nanoparticles.
Wednesday, July 10, 2013
New Imaging Technology Could Reveal Cellular Secrets
Researchers have married two biological imaging technologies, creating a new way to learn how good cells go bad.
Friday, April 26, 2013
Gene's function May Give New Target for Cancer Drugs
Scientists have determined that a gene long known to be involved in cancer cell formation and chemotherapy resistance is key to proper RNA creation, and could one day lead to new therapies and drug targets.
Thursday, September 13, 2012
Imaging Tool Tracks Carbon Nanotubes in Living Cells
Researchers have demonstrated a new imaging tool for tracking structures called carbon nanotubes in living cells and the bloodstream, which could aid efforts to perfect their use in biomedical research and clinical medicine.
Thursday, December 08, 2011
Genome Sequencing Speeds Ability to Improve Soybeans
Purdue researchers are sequencing the soybean genome to better understand its genes and to improve its characteristics.
Friday, January 15, 2010
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Genetic Tug of War
Researchers have reported on a version of genetic parental control in mice that is more targeted, and subtle than canonical imprinting.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
How to Become a Follicular T Helper Cell
Uncovering the signals that govern the fate of T helper cells is a big step toward improved vaccine design.
Researchers Resurrect Ancient Viruses
Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
Expanding the Brain
A team of researchers has identified more than 40 new “imprinted” genes, in which either the maternal or paternal copy of a gene is expressed while the other is silenced.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
Study Uncovers Target for Preventing Huntington’s Disease
Scientists from Cardiff University believe that a treatment to prevent or delay the symptoms of Huntington’s disease could now be much closer, following a major breakthrough.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!