Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scientists Throw New Light on DNA Copying Process

Published: Monday, April 22, 2013
Last Updated: Monday, April 22, 2013
Bookmark and Share
Research has thrown new light on the way breakdowns in the DNA copying process inside cells can contribute to cancer and other diseases.

Peter McGlynn, an Anniversary Professor in the University's Department of Biology, led a team of researchers who have discovered that the protein machines that copy DNA in a model organism pause frequently during this copying process, creating the potential for dangerous mutations to develop.

The research, funded by BBSRC and published in the Proceedings of the National Academy of Sciences (PNAS), involved scientists at the School of Medical Sciences at the University of Aberdeen, where Professor McGlynn worked previously, the Centre for Genetics and Genomics at the Queen's Medical Centre, University of Nottingham and the Memorial Sloan-Kettering Cancer Center, New York.

The project focused on a bacterium called Escherichia coli which is a powerful model for studying the DNA copying process, the study of which has revealed many aspects of DNA metabolism in more complex organisms such as man.

Professor McGlynn, who was one of 16 Chairs established at York to mark the University's 50th Anniversary, says: "Our work demonstrates that when organisms try to copy their genetic material, the copying machines stall very frequently which is the first step in formation of mutations that, in man, can cause cancers and genetic disease.

"We have analysed what causes most of these breakdowns and how, under normal circumstances, cells repair these broken copying machines. Just as importantly, our work reveals that efficient repair of these breakdowns is very important to avoid corruption of the genetic code."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Tissue Damage Is Key for Cell Reprogramming
Researchers have shown tissue damage is important for cells to return to an embryonic state for cell reprogramming.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
New Form of Autism Found
An international team of researchers have identified a new form of syndromic autism.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
Secret Phenotypes: Disease Devils in Invisible Details
Algorithmic deep phenotyping exposes masses of hidden traits and possible subtle genetic connections relevant to unseen influences on disease.
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!