Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

SentoClone Significantly Strengthens its Global Patent Portfolio

Published: Friday, June 07, 2013
Last Updated: Friday, June 07, 2013
Bookmark and Share
New patents granted in Japan, the USA and Europe.

SentoClone International AB has announced that it has been granted additional patents in Japan, the US and Europe further reinforcing the global protection of its proprietary SentoClone® technology, an active patient specific cellular immunotherapy against cancer based on the ex vivo cultivation and activation of CD4+ T-cells.

The technology has advanced to Phase II clinical trials following Phase I and pilot studies in patients with colorectal and bladder cancer.

SentoClone International´s chairman Pingsheng Hu said, "We are determined to develop our SentoClone® technology as rapidly as possible so that it can become an effective patient specific cancer therapy without significant side effects for the broad range of cancer patients worldwide. The recent patents we have been granted in Japan, the US and Europe means we have very solid IP in all major markets in the field of sentinel node derived T-cells in cancer therapy. We believe this much stronger patent protection will allow us to attract development partners so that we can make this novel approach to cancer therapy available to the many patients globally who could benefit."

The SentoClone® technology builds on a unique approach whereby CD4+ T- helper cells, highly specific for the patient’s individual tumor, are extracted from the tumor’s draining lymph node (the sentinel node) and cultivated ex vivo in a GMP production facility before being returned to the patient via one single infusion.

During cultivation, the T-cells are stimulated with growth factors and re-activated with antigen from the patient’s individual tumor.

Once returned to the patient the T-cells induce effector cells of the immune system to attack the tumor tissue highly specifically, leaving other tissue unaffected.

Evidence indicates that the technology also generates a powerful long-term immunologic memory where T-cells are patrolling the body in a process called immunosurveillance.

To-date more than 200 patients with a range of cancers have been treated using this unique approach with no significant side effects being reported.

The safety profile, combined with its synergistic mode of action, suggest that SentoClone® technology could be an ideal addition to current or upcoming cancer treatment regimens.

The recent patents granted to SentoClone covering its Sentinel node-derived CD4 T-cell cancer therapy are as follows:
• In Japan, patent 5244610, titled “Improved method for expansion of tumour-reactive T-lymphocytes for immunotherapy in cancer” covers the process of ex vivo cultivation and activation of CD4+ T-cells. It is the Company´s second patent granted in Japan during 2013.
• In Europe, patent EP 1966370B1, titled “Method for obtaining T-lymphocytes” covers the use in cancer immunotherapy of T-cells derived from metastasis-draining lymph nodes (“metinel nodes”). It is the Company´s third European patent and is presently being validated in the major European countries.
• In the USA, patent US 8211425B2, titled “Method for treating disseminated cancer” is the Company´s sixth patent granted in the US and covers the use of metinel node T-cells in cancer immunotherapy.

SentoClone International holds 24 international patents, including these new grants, within eight families.

The portfolio comprises six patents in the USA, three patents in Europe and two patents in Japan.

In addition, SentoClone International’s Chinese parent company Jiangsu Sinorda Biomedicine Co. holds patents for the Chinese market.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Secret Phenotypes: Disease Devils in Invisible Details
Algorithmic deep phenotyping exposes masses of hidden traits and possible subtle genetic connections relevant to unseen influences on disease.
Cracking the Code of a Deadly Virus
Researchers have exploited weaknesses in VEEV's genetic code, creating a far less deadly variant.
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
Repurposing Genes for Brain Development
Mammalian bone gene may be repurposed to promote cognition in humans.
Enhancing CRISPR to Explore Further
Researchers have developed sOPTiKO, a more efficient and controllable CRISPR genome editing platform.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!