Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

CeMM and Haplogen Make Available the World’s Largest Collection of Human Cell Lines

Published: Monday, September 02, 2013
Last Updated: Monday, September 02, 2013
Bookmark and Share
Haplogen and CeMM partnership will distribute requested cell lines to the research community.

Haplogen and CeMM have announced that they are making available their large collection of human cell lines that are deficient for single genes, which they have been building over the past three years as part of a public-private partnership.

The partnership, through Haplogen, will distribute requested cell lines to the research community. The collection and the technological advances that enabled its development were published in Nature Methods on August 25.

It currently includes cell line clones covering 3,000 different human genes, which represents about one third of all the genes that are active in these cells. The collection will continue to expand until all the genes have been targeted.

Although cell lines of human origin have been around for many years, they are all vastly different from each other, making them very difficult to control when performing genetic experiments, thereby limiting their use particularly for drug discovery efforts and discovering the function of genes.

This new collection circumvents this problem by providing individual gene mutations in an otherwise identical genetic background.

Prof. Giulio Superti-Furga, Director of the CeMM who initiated this project commented: “This collection will fuel research in molecular medicine where the vast majority of human genes remain poorly understood and await functional characterization. Obtaining human cells where an individual gene is inactivated has so far been difficult and very tedious. With this largest human cell line collection available to date we expect to drive countless scientific discoveries in the research community.”

“The creation of those precise mutants has become possible by the use of a haploid cell line. Destroying a single gene in haploid cells will immediately cause a detectable change - in contrast to our natural cells that always bear two copies of each gene” explains Thijn Brummelkamp, the inventor of the haploid genetics technology in human cells that was used to create this collection, and founder of Haplogen.

Georg Casari, CEO of Haplogen: “In this publication we show that these cell lines really behave as if only the gene of choice is no longer present. We have taken great care to document that the gene products are gone and that those clones have new properties as compared to the parental, unmodified cell line. We are excited to provide and distribute this resource to researchers world-wide and contribute to the advancement of medical research. Our goal is to eventually obtain mutant cell lines for every human gene.”

He continued: "At Haplogen we use this collection as an indispensable component in our research and development of antiviral medications for treating a wide range of harmful infectious diseases. This partnership of academic research at CeMM and private investment by the company has made it possible to finance this collection and build a resource to the benefit beyond the two institutions for scientists all over the world.”

The cell line collection has received financial support also from ZIT (Technology agency of the City of Vienna) and can be explored at

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
GMO Food Animals Should be Judged by Product, Not Process
In a world with a burgeoning demand for meat, milk and eggs, regulatory policies around the use of biotechnologies in agriculture need to be based on the safety and attributes of those foods rather than on the methods used to produce them, says a UC Davis animal scientist.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
Gene Drive Reversibility Introduces New Layer of Biosafety
Ability to introduce or reverse the spread of genetic traits through populations could one day improve pest management and disease control.
RNA-Based Drugs Give More Control Over Gene Editing
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos