Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

CeMM and Haplogen Make Available the World’s Largest Collection of Human Cell Lines

Published: Monday, September 02, 2013
Last Updated: Monday, September 02, 2013
Bookmark and Share
Haplogen and CeMM partnership will distribute requested cell lines to the research community.

Haplogen and CeMM have announced that they are making available their large collection of human cell lines that are deficient for single genes, which they have been building over the past three years as part of a public-private partnership.

The partnership, through Haplogen, will distribute requested cell lines to the research community. The collection and the technological advances that enabled its development were published in Nature Methods on August 25.

It currently includes cell line clones covering 3,000 different human genes, which represents about one third of all the genes that are active in these cells. The collection will continue to expand until all the genes have been targeted.

Although cell lines of human origin have been around for many years, they are all vastly different from each other, making them very difficult to control when performing genetic experiments, thereby limiting their use particularly for drug discovery efforts and discovering the function of genes.

This new collection circumvents this problem by providing individual gene mutations in an otherwise identical genetic background.

Prof. Giulio Superti-Furga, Director of the CeMM who initiated this project commented: “This collection will fuel research in molecular medicine where the vast majority of human genes remain poorly understood and await functional characterization. Obtaining human cells where an individual gene is inactivated has so far been difficult and very tedious. With this largest human cell line collection available to date we expect to drive countless scientific discoveries in the research community.”

“The creation of those precise mutants has become possible by the use of a haploid cell line. Destroying a single gene in haploid cells will immediately cause a detectable change - in contrast to our natural cells that always bear two copies of each gene” explains Thijn Brummelkamp, the inventor of the haploid genetics technology in human cells that was used to create this collection, and founder of Haplogen.

Georg Casari, CEO of Haplogen: “In this publication we show that these cell lines really behave as if only the gene of choice is no longer present. We have taken great care to document that the gene products are gone and that those clones have new properties as compared to the parental, unmodified cell line. We are excited to provide and distribute this resource to researchers world-wide and contribute to the advancement of medical research. Our goal is to eventually obtain mutant cell lines for every human gene.”

He continued: "At Haplogen we use this collection as an indispensable component in our research and development of antiviral medications for treating a wide range of harmful infectious diseases. This partnership of academic research at CeMM and private investment by the company has made it possible to finance this collection and build a resource to the benefit beyond the two institutions for scientists all over the world.”

The cell line collection has received financial support also from ZIT (Technology agency of the City of Vienna) and can be explored at http://clones.haplogen.org.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Liquid Biopsies: Miracle Diagnostic or Next New Fad?
Thanks to the development of highly specific gene-amplification and sequencing technologies liquid biopsies access more biomarkers relevant to more cancers than ever before.
Discovered Through ‘Big Data’ Analysis
Researchers at the SBP have identified over 100 new genetic regions that affect the immune response to cancer.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer and that, when deleted in the lungs of mice, prevents the cancer from forming.
Deciphering Inactive X Chromosomes
Untangling the Barr body of inactive X chromosomes valuable for understanding chromosome structure and gene expression.
Micro Disease-Detecting Senor Created
Researchers at McMaster University have created a microscopic disease-detecting sensor that can turn on to detect trace amounts of substances.
Liquid Biopsies Treating Ovarian Cancer
Researchers have discovered a promising monitor and treat recurrence of ovarian cancer. Detecting cancer long before tumours reappear.
Uncovering a New Principle in Chemotherapy Resistance in Breast Cancer
The NIH study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes.
Understanding Treatment Resistant Melanoma
Researchers have determined how advanced melanoma becomes resistant; a development toward developing treatments.
Investigating ‘Black Box’ of Human Genetics
Investigations into inactive X chromosomes have shown unusual DNA repeat elements are essential for maintaining 3D structure.
Liquid Biopsies: DNA Size Matters
Study finds circulating tumour DNA can be distinguished from healthy DNA through fragment size identification.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!