Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

International Research Project Identifies a New Genetic Mutation that Helps Explain the Development of Eczema

Published: Monday, November 04, 2013
Last Updated: Monday, November 04, 2013
Bookmark and Share
Scientists have identified a new genetic mutation linked to the development of a type of eczema known as atopic dermatitis (AD).

They found that a mutation in the gene Matt/Tmem79 led to the development of spontaneous dermatitis in mice. The gene is involved in producing a protein, now called ‘mattrin’. However, protein expression was defective in individuals with the mutant gene, and this led to skin problems. In humans, mattrin is expressed within the cells that produce and maintain the skin’s function as a barrier.

After identifying the relationship between the mutation and AD, the scientists looked for a similar pattern in people. They screened large cohorts of patients that suffered from AD, comparing them with unaffected control patients, and found that the equivalent human gene MATT/TMEM79 was similarly associated. The results of this study are published in the November issue of the leading peer-reviewed journal in allergy research, The Journal of Allergy and Clinical Immunology.

Professor Padraic Fallon, Chair of Translational Immunology in the School of Medicine at Trinity, who led the project, said:  “We have identified a new gene mutation that leads to atopic dermatitis (AD) in mice, and have taken that work further to demonstrate that a variant of the human gene is associated with AD in patients.”

Professor Fallon added: “This study highlights the value of research in which genetic patterns in animals provide a starting point to investigating human disease. This strategy enables us to identify new genes that are relevant in human disease and then examine the function of these genes during inflammation. This approach will ultimately help us to understand the factors leading to inflammatory diseases and assist in the development of new therapeutic strategies.”

Professor Irwin McLean, Scientific Director of the Centre for Dermatology and Genetic Medicine at the University of Dundee, jointly led the research that involved collaboration between scientists in Ireland, the United Kingdom, USA, Germany and Singapore. The work was funded by grants from the Wellcome Trust, Science Foundation Ireland and the National Children’s Research Centre.

Professor McLean added: “This study shows that disruption of the barrier function of the skin is a key driving force in the development of eczema.  Without an intact skin barrier, foreign substances can enter the body and trigger inflammation and allergy.”

AD is the most commonly diagnosed skin condition, affecting up to 20% of children. As well as having a genetic basis, the condition can also be triggered by environmental factors, such as pet fur, pollen and house dustmites. Dairy products, eggs, nuts and wheat have also been linked to the condition.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Scientists Discover Genetic Basis for Memory Formation with Implications for Neurological Diseases
Two genes linked to simple memory formation also regulate appropriate nerve responses that are lacking in related disease sufferers.
Monday, December 23, 2013
Genetic Mutation Could Increase Understanding of ADHD
Absence of normal gene that expresses a protein involved in nerve cell communication results in seizures and hyperactivity.
Wednesday, November 27, 2013
New Genetic Mutation Helps Explain Development of Eczema
Researchers found that a mutation in the gene Matt/Tmem79 led to the development of spontaneous dermatitis in mice.
Monday, November 04, 2013
Scientists Propose a Molecular Explanation for Degenerative Disease
An international collaboration has shed new light on the origins and molecular causes of age related degenerative conditions including Motor Neurone Disease (MND).
Monday, August 19, 2013
Scientific News
Gene Therapy Via Ultrasound
Research into a gene therapy approach called sonoporation could help combat heart disease and cancer.
Creating Embryos with 'Heteroplasmy'
New discovery in genetic research could lead to treatments for mitochondrial diseases.
Proteins Preserve Vital Genetic Data
Research has shown how two key proteins bring about the oragnization of chromosomes and our genome.
Novel MRI Technique Distinguishes Healthy Prostate Tissue from Cancer
The UTSW researchers have determined that glucose stimulates release of the zinc ions from inside epithelial cells, which they could then track on MRIs.
Eye Colour Determines Cancer Risk
Researchers report first findings of a link between eye pigment gene and uveal melanoma development.
Telomere Replenishment in Real Time
Researchers have visualised the process of telomere attachment to chromosomes through single-molecule imaging.
Converting Isolated Cells with Gene Editing
Researchers have used CRISPR to generate neuronal cells from isolated connective tissue.
New Inflammatory Disease Discovered
NIH researchers have discovered a rare and potentially deadly disease - otulipenia - the mostly affects children.
Gene Linked to Hearing Loss Identified
Researchers have identifed a gene associated with age-related hearing loss.
Oxygen Content Contributes to Cancer
Research project concludes lack of oxygen in tumour cells changes cell gene expression, contributing to the growth of cancer.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!