Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetic Aberration Paves the Way for New Treatment of Cancer Disease

Published: Friday, November 08, 2013
Last Updated: Friday, November 08, 2013
Bookmark and Share
Research was recently published in Scandinavian Journal of Gastroenterology.

Researchers from Faculty of Health and Medical Sciences, University of Copenhagen, have characterized a genetic aberration on a group of colorectal cancer patients.

The discovery gives hope for a new and efficient treatment of colorectal cancer, which is a frequent and often fatal disease.

12-15 years of development and millions of dollars are typically the costs, when companies develop a new anti-cancer drug.

Therefore all short cuts to a treatment are welcome. Researchers at Department of Veterinary Disease Biology, University of Copenhagen, recently discovered such a potential short cut.

“Our new research shows, that we might be able to introduce a treatment faster and cheaper than usual in the development of cancer treatment, and we estimate that it will be efficient in around 10 per cent of patients with colorectal cancer," says MD and PhD student Sune Nygård, Department of Veterinary Disease Biology, University of Copenhagen.

Re-use of existing breast cancer treatment
In the new study the researchers have shown that around 10 per cent of colorectal cancer patients harbor an aberration in the gene called TOP2A in their cancer cells. These tumors could potentially benefit from treatment with a specific chemotherapeutic drug - a so-called “anti-TOP2A treatment”, which is already used in breast cancer patients with this gene aberration.

Clinical study begins
Approximately 600,000 patients die of colorectal cancer each year worldwide.

“If the first treatment doesn’t cure a patient with colorectal cancer, the possibilities of additional treatment are limited,” says Nils Brünner, MD, professor at University of Copenhagen. “Therefore it is very important to find a new, efficient treatment,” he adds.

The research group from the Department of Veterinary Disease Biology and professor Per Pfeiffer at Odense University Hospital have received funds from The Danish Cancer Society to initiate a clinical trial.

Here it will be tested, if patients with the TOP2A gene defect could benefit from the targeted anti-TOP2A treatment.

“It is unique to go from a discovery in the laboratory towards a treatment for cancer patients at this pace. This is only possible when researchers and doctors work closely together,” says Nils Brünner, University of Copenhagen.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

World’s Tiniest Drug Cabinets could be Attached to Cancerous Cells for Long Term Treatment
Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments.
Wednesday, January 15, 2014
New Protein Knowledge Offers Hope for Better Cancer Treatment
Researchers have developed a sophisticated method for identifying modified proteins that affect a cell's ability to repair DNA damage.
Friday, September 20, 2013
Discovering the Secrets of Tumour Growth
Scientists have identified a compound that blocks the expression of a protein without which certain tumours cannot grow.
Monday, January 28, 2013
Waking the Dead - Scientists Reconstruct the Nuclear Genome of an Extinct Human Being
The discovery improves our understanding of heredity and the disease risk passed down from our ancestors, Copenhagen scientists say.
Monday, February 15, 2010
Isolation of a new Gene Family Essential for Early Development
Researchers have identified a new gene family essential for embryonic development that may contribute to the understanding of the development of cancer.
Thursday, August 23, 2007
University of Copenhagen Wins Novo Nordisk Grant to Build Proteomics Center
The University of Copenhagen in Denmark plans to use a KRO 600 million grant from the Novo Nordisk Foundation to build a protein research center.
Monday, May 07, 2007
Scientific News
Poor Survival Rates in Leukemia Linked to Persistent Genetic Mutations
For patients with an often-deadly form of leukemia, new research suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Searching Big Data Faster
Theoretical analysis could expand applications of accelerated searching in biology, other fields.
Growing Hepatitis C in the Lab
Recent discovery allows study of naturally occurring forms of hepatitis C virus (HCV) in the lab.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
Genetic Overlapping in Multiple Autoimmune Diseases May Suggest Common Therapies
CHOP genomics expert leads analysis of genetic architecture, with eye on repurposing existing drugs.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!