Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Novel Cancer Cell DNA Damage Repair Mechanism

Published: Monday, December 23, 2013
Last Updated: Monday, December 23, 2013
Bookmark and Share
Findings result from application of the cell microarray screening method developed at VTT.

Cancer cells have an exceptional ability to repair damage to their DNA caused during uncontrolled cell division. Scientists have now unveiled a novel piece of the puzzle of cancer cell DNA repair mechanisms that explain the mechanistic changes in the genetic code of cancer cells.

Research with a material impact on cancer drug development was published in Science magazine on 5 December 2013.

The new findings explain partially why cancer cells, unlike normal cells, fail to die as a result of DNA damaging insults, and how this mechanism causes new genetic mutations in cancer cells. This new information directly benefits cancer research.

Now that scientists understand the repair mechanism, they are better equipped to develop drug therapies that specifically target cancerous cells.

The discovered DNA repair mechanism has previously not been described in human or mammalian cells. Cancer cells use the mechanism to repair DNA damage resulting from uncontrolled DNA replication forced by activated oncogenes.

The genes that participate in the DNA repair mechanism were discovered by Juha Rantala, Senior Scientist at VTT, and Thanos Halazonetis, Coordinator of the EU-funded GENICA (Genomic instability in cancer and pre-cancer) project, with the cell microchip screening method developed by Rantala in 2010. Based on gene silencing, the method allows a single microchip to screen the functions of tens of thousands of genes simultaneously.

This finding was preceded by years of research cooperation begun by Juha Rantala, Senior Scientist, and Professor Olli Kallioniemi (currently Director of the Finnish Institute of Molecular Medicine) from VTT and Professor Thanos Halazonetis (the University of Geneva). Thomas Helleday's research team at the Karolinska Institutet also participated in the research published in Science magazine.

The research was part of the EU's GENICA project aimed at discovering why the DNA damage sustained by cancer cells in the early stages of the disease fails to result in the programmed cell death associated with normal cells.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Heparin-like Compounds Inhibit Breast Cancer Metastasis to Bone
Heparin-like compounds decreased bone destruction and tumor growth in bone.
Friday, June 15, 2012
VTT Develops Software Tool to Integrate and Analyze Complex Medical Data
The megNet® software can be applied in understanding complex relations in living organisms, and characterizing various diseases, such as cardiac diseases and diabetes.
Friday, April 27, 2007
Scientific News
Researchers Develop Classification Model for Cancers Caused by KRAS
Most frequently mutated cancer gene help oncologists choose more effective cancer therapies.
Chromosomal Chaos
Penn study forms basis for future precision medicine approaches for Sezary syndrome
Shaking Up the Foundations of Epigenetics
Researchers at the Centre for Genomic Regulation (CRG) and the University of Barcelona (UB) published a study that challenges some of the current beliefs about epigenetics.
Genetic Defences of Bacteria Don’t Aid Antibiotic Resistance
Genetic responses to the stresses caused by antibiotics don’t help bacteria to evolve a resistance to the medications, according to a new study by Oxford University researchers.
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
3 Ways Viruses Have Changed Science for the Better
Viruses are really good at what they do, and we’ve been able to harness their skills to learn about – and potentially improve – human health in several ways.
Mixed Up Cell Transportation Key Piece of ALS and Dementia Puzzle
Researchers from the University of Toronto are one step closer to solving this incredibly complex puzzle, offering hope for treatment.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos