Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Fruit Fly Cells Offer Cancer Insights

Published: Friday, January 03, 2014
Last Updated: Friday, January 03, 2014
Bookmark and Share
Researchers at the University of Exeter have shown that cells demonstrate remarkable flexibility and versatility when it comes to how they divide.

The study, published in Developmental Cell, describes a number of routes to the formation of a microtubule spindle – the tracks along which DNA moves when a cell divides in order to make two genetically identical cells.

In order to understand the phenomenon, the authors, including Biosciences researchers Professor James Wakefield, PhD student Daniel Hayward and Experimental Officer in Image Analysis, Dr. Jeremy Metz, combined highly detailed microscopy and image analysis with genetic and protein manipulation of fruit fly embryos.

The innovative research not only describes how the cell can use each pathway in a complementary way, but also that removal of one pathway leads to the cell increasing its use of the others. The researchers also identified that a central molecular complex – Augmin – was needed for all of these routes.

The authors were the first to identify that each of four pathways of spindle formation could occur in fruit fly embryos.

It was previously thought that, in order for chromosomes – packages containing DNA – to line up and be correctly separated, microtubules have to extend from specific microtubule-organising centres in the cell, called centrosomes. However, this study found that microtubules could additionally develop from the chromosomes themselves, or at arbitrary sites throughout the main body of the cell, if the centrosomes were missing.

All of these routes to spindle formation appeared to be dependent on Augmin - a protein complex responsible for amplifying the number of microtubules in the cell.

Dr. Wakefield said of the project “We have all these different spindle formation pathways working in humans. Because the cell is flexible in which pathway it uses to make the spindle, individuals who are genetically compromised in one pathway may well grow and develop normally. But it will mean they have fewer routes to spindle formation, theoretically predisposing them to errors in cell division as they age.”

The group are currently investigating cancer links in light of these findings.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

How Baby’s Genes Influence Birth Weight And Later Life Disease
The large-scale study could help to target new ways of preventing and treating these diseases.
Friday, September 30, 2016
Genetics Reveals Patients Susceptible to Drug-induced Pancreatitis
Doctors have discovered that patients with a particular genetic variation are four times more likely to develop pancreatitis if they are prescribed a widely used group of drugs.
Friday, September 19, 2014
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Diabetes Missing Link Discovered
Researchers from the University of Auckland have shown that beta catenin plays a vital role in the control of insulin release from the pancreas.
Study Reveals New Role for Hippo Pathway in Suppressing Cancer Immunity
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development.
Gene Editing Yields Tomatoes That Ripen Weeks Earlier
Research team develop method to make tomato plants flower and ripen fruit two weeks faster than current growth rates.
Exploring the Genome of the River Blindness Parasite
Researchers have decoded the genome of the parasite that causes the skin and eye infection known as river blindness.
Gene-Editing Improves Vision in Blind Rats
Scientists developed a targeted gene-replacement technique that can modify genes in both dividing and non-dividing cells in living animals.
Unexpected Role for Epigenetic Enzymes in Cancer
Researchers use epigenetics to identify the role of an enzyme family as regulators of genetic message interpretation in yeast.
Genetic Links to Brain Cancer Cell Growth
Researchers discover clues to tumour behaviour from genetic differences between brain cancer cells and normal tissue cells.
Gene Therapy Maintains Clotting Factor for Hemophilia Patients
Following a single gene therapy dose, the highest levels of an essential blood clotting factor IX were observed in hemophilia B patients.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!