Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Integrated DNA Technologies Advances Human Health and Clinical Research

Published: Monday, March 24, 2014
Last Updated: Monday, March 24, 2014
Bookmark and Share
Company extends its portfolio of NGS panels with the addition of the xGen® Inherited Disease and Pan-Cancer Panels.

Adding these to the xGen AML Panel which was launched at the end of last year, IDT now offers a range of panels for deep sequencing that can be supplemented to cover a comprehensive range of diseases.

The xGen Inherited Disease Panel will be officially launched at the ACMG Annual Clinical Genetics Meeting, March 26–28. Designed in collaboration with Emory Genetics Laboratory (EGL), this panel was created to combine the ease of whole exome sequencing with the low cost of panels. Emory leveraged Integrated DNA Technologies (IDT ) Lockdown Probes to create a library targeting all exons in HGMD (human gene mutation database) listed genes. The creation of this library simplifies workflow and lowers costs, while facilitating rapid sequencing and providing the high coverage levels needed for clinical diagnostics application of NGS. During ACMG (EGL) will present a poster entitled, “One library, many tests: The evolution of next generation sequencing panel testing”.

The xGen Pan-Cancer Panel, which will be launched at AACR, April 5–9, is based on the findings of The Cancer Genome Atlas (TCGA) network. NGS has enabled the discovery and characterization of gene-specific mutations that have the potential to be tumorigenic, but it also implicates irrelevant genes. A shortlist of significant genes that are relevant across numerous cancer types, which can be expanded by including additional tumor-specific genes, would be extremely valuable for both clinical and research applications. TGCA network have identified 127 significantly mutated genes across 12 tumor types. The Pan-Cancer Panel targets coding regions in all 127 genes.

Target enrichment enables users to focus their sequencing efforts on specific regions of the genome, providing a cost-effective and reliable alternative to whole genome sequencing, and making NGS more accessible. Ibrahim Jivanjee, Product Manager for NGS at IDT, commented, “Having launched our xGen AML Panel last October, we have invested a significant amount of time and resources into further developing our NGS capabilities. A rapidly advancing area, next generation sequencing is key to the development of personalized medicine, and these two new panels will aid us in supporting advancements in human health and clinical research.”

All three of the IDT NGS Panels feature xGen Lockdown® Probes, which are 120mer oligonucleotides with a 5’ biotin modification. Synthesized individually using the IDT Ultramer® synthesis platform, Lockdown Probes incorporate the highest coupling rate currently available, 99.6%, to provide high quality, long oligos. The quality of each capture probe is assessed using electrospray ionization mass spectrometry and even probes with a high GC content can be synthesized.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Dr Patricia Tavormina Named Winner of First IDT ISO 14001 Sustainability Award
Biodiversity research on methane sinks and global warming earns $14,001 in oligo credit.
Thursday, September 10, 2015
Untangling the Web of Gene Expression
New technology for understanding gene expression drives research forward.
Wednesday, May 20, 2015
Discover Affordable Custom NGS Panels
IDT webinar helps NGS researchers bring cost-savings to target capture panels.
Thursday, February 12, 2015
Synthetic Biology Webinar - Genome Modifications Made Easy
IDT reveals how to overcome the challenges of CRISPR-mediated genome editing.
Thursday, January 15, 2015
Discover the Latest NGS-Based Assays Guiding Precision Oncology
IDT joins forces with Foundation Medicine in AMP workshop.
Saturday, November 08, 2014
IDT Acquires SURVEYOR® Nuclease Business from Transgenomic
Addition of SURVEYOR enzyme and kits expands IDT's molecular biology product offerings.
Wednesday, July 02, 2014
World Cup 2014 - with a Scientific Twist
IDT fuses fruit flies, football and fun in a unique global contest with great prizes.
Thursday, June 12, 2014
Summit Partners Makes Growth Equity Investment in IDT
IDT’s founder, Dr. Joseph Walder, will remain the company’s majority owner.
Wednesday, March 19, 2014
Enhanced Molecular Inversion Probes for NGS Target Enrichment
IDT presents latest developments at 15th annual Advances in Genome Biology and Technology meeting.
Tuesday, February 04, 2014
Providing a Rapid and Reliable Method of Gene Cloning
Integrated DNA Technologies will be speaking at the upcoming Antibody Engineering and Therapeutics conference.
Monday, December 02, 2013
IDT Provides Insights into the World of Gene Construction
Informative and educational talk to take place at SynBioBeta 2013.
Thursday, November 14, 2013
Discussing the Science of Big DNA
Read about the most recent advances in synthetic biology in the latest issue of DECODED.
Monday, September 23, 2013
IDT Opens SGD 6 Million Manufacturing Facility in Singapore
IDT is now able to provide locally-manufactured oligonucleotides to researchers in Singapore and throughout the region.
Wednesday, July 24, 2013
Webinar: the Cutting-edge qPCR Approach to Single-cell Expression Profiling
Join IDT and Professor Mikael Kubista for insight into pioneering qPCR methods, June 25.
Monday, June 24, 2013
Building Novel DNA Constructs at ASM
IDT invite scientists to discover a cost-effect approach to sequence constructs.
Tuesday, May 14, 2013
Scientific News
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
GMO Food Animals Should be Judged by Product, Not Process
In a world with a burgeoning demand for meat, milk and eggs, regulatory policies around the use of biotechnologies in agriculture need to be based on the safety and attributes of those foods rather than on the methods used to produce them, says a UC Davis animal scientist.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos