Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Immatics to Continue Work on Vaccine (IMA950) for Glioblastoma

Published: Thursday, April 24, 2014
Last Updated: Thursday, April 24, 2014
Bookmark and Share
A new cancer vaccine (IMA950) for glioblastoma has met the two primary endpoints of safety and immunogenicity in a trial conducted by Cancer Research UK.

immatics biotechnologies GmbH, together with its collaborators Cancer Research UK and Cancer Research Technology has announced that they have entered a license agreement in which immatics will continue to develop its cancer vaccine IMA950 for glioblastoma, the most common and lethal adult brain tumour.

The decision is based on positive results from a phase 1 trial that was conducted under the Clinical Development Partnerships (CDP) joint initiative of Cancer Research UK’s Drug Development Office (DDO) and Cancer Research Technology (CRT) as part of the charity’s role in assessing new treatments of potential benefit to cancer patients.

IMA950 is a vaccine that uses 11 different HLA-restricted tumour-associated peptides (TUMAPs). The TUMAPs, identified by immatics using its proprietary drug discovery platform XPRESIDENT®, are known to be over-expressed on the surface of glioblastoma tumours. They trigger the patient’s immune system to recognize and kill tumour cells while leaving healthy cells unharmed.

The IMA950 trial met the agreed primary endpoints of safety and immunogenicity in a phase 1 multicentre trial which was undertaken at seven Experimental Cancer Medicine Centres across the UK, led by the Beatson West of Scotland Cancer Centre in Glasgow. 45 patients with newly diagnosed glioblastoma were treated with IMA950 in addition to standard of care, surgery and concomitant or adjuvant chemotherapy with temozolomide. Results showed that 90 per cent of patients responded to the vaccine, in comparison to the pre-defined goal of 60 per cent, exceeding expectations.

IMA950 is the first therapeutic vaccine developed under the CDP scheme. Under the scheme, companies retain rights to their drugs while allowing Cancer Research UK’s DDO to undertake early clinical development work to assess the treatment’s benefit to cancer patients.

Nine projects have been taken on under the CDP initiative with IMA950 being the first to complete a clinical trial and be taken forward by the company. immatics has paid CRT an undisclosed licensing fee for exclusive rights to the phase 1 clinical trial data and, provided IMA950 is successfully developed and commercialized, will pay further development milestones and downstream royalties.

Professor Roy Rampling, chief investigator for the study and Honorary Senior Research Fellow at the Beatson West of Scotland Cancer Centre, said: “Brain tumours are a particularly difficult type of cancer to treat with conventional methods, but they have recently been accepted as a possible target for immunotherapy - increasingly recognized as a potentially important approach to treating cancer.

“In our study we investigated whether patients newly diagnosed with the most common and aggressive type of malignant brain tumour called glioblastoma could mount an appropriate immune response when given IMA950 and if the vaccine was safe. IMA950 was very simple to administer and was very well tolerated. Importantly, we were very pleased to see that nearly all patients mounted an immune response that could be detected in the blood, which is the first step in establishing clinical activity before determining patient benefit in subsequent studies.”

Paul Higham, CEO of immatics, said: “I am delighted that we are in a position to take the development of IMA950 forward for the treatment of patients with glioblastoma. This is our third cancer vaccine to have shown promising results. There is clearly a high need for new therapies for glioblastoma, which is a very hard-to-treat cancer, with very poor survival rates. The DDO has been an excellent partner and we are very grateful for the work they have done in further characterizing the positive attributes of IMA950.”

Dr Nigel Blackburn, Cancer Research UK’s director of the DDO, said: “We’re extremely pleased that our collaboration with immatics has yielded positive phase 1 data with IMA950 and that through our Clinical Development Partnerships initiative we have been able to ensure it has the potential to reach patients sooner. Better treatment options for glioblastoma are badly needed and we hope that the potential of this novel approach will be confirmed in future clinical studies.

“Cancer Research UK is committed to playing a key role in the development of improved cancer therapies and we see collaborations with a broad range of partners, such as immatics, as critical to achieving this very important goal.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

immatics and BioNTech to Advance a Novel Class of Fully Personalized Therapeutic Cancer Vaccines
Regulatory authority approves clinical trial for Glioma Actively Personalized Vaccine Consortium (GAPVAC).
Thursday, October 16, 2014
immatics Receives €22 Million Final Tranche of Series D Fundraising
Funds will be used to complete phase 3 study with IMA901 and to invest in the expansion of immatics’ Human Immunopeptidome Program to identify the most relevant targets for cancer immunotherapies.
Thursday, July 17, 2014
immatics Closes €34 Million Financing
immatics’ lead cancer vaccine IMA901 to report interim phase 3 data in 2014 and final data in 2015.
Tuesday, October 15, 2013
Professor Dr Hans-Georg Rammensee Awarded the Bayer Hansen Family Award 2013
Prestigious Hansen Family Award recognizes Hans-Georg Rammensee’s pioneering scientific research activities.
Friday, March 08, 2013
immatics Presents Encouraging Overall Survival Data from a Phase 2 Study in CRC
T-cell responses to the IMA910 colorectal cancer vaccine peptides show a clear correlation with longer overall survival.
Monday, June 04, 2012
immatics Wins 2012 TiE50 Award
immatics chosen as a leading company in the life sciences category by the world's largest entrepreneurial network.
Friday, May 25, 2012
immatics Appoints Dr Rainer Kramer as CBO
Dr. Kramer will lead immatics’ business development unit.
Thursday, April 12, 2012
immatics Presents Positive Phase II Results with IMA910 in CRC Patients
Study shows a consistent association between immune response to IMA910 and all clinical endpoints and an excellent tolerability profile.
Wednesday, January 25, 2012
Scientific News
New Tech Vastly Improves CRISPR/Cas9 Accuracy
A new CRISPR/Cas9 technology developed by scientists at UMass Medical School is precise enough to surgically edit DNA at nearly any genomic location, while avoiding potentially harmful off-target changes typically seen in standard CRISPR gene editing techniques.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Biologists Induce Flatworms to Grow Heads and Brains of Other Species
Findings shed light on role of a new kind of epigenetic signaling in evolution, could yield clues for understanding birth defects and regeneration.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Ancient Viral Molecules Essential for Human Development
Genetic material from ancient viral infections is critical to human development, according to researchers at the Stanford University School of Medicine.
Tardigrade's Are DNA Master Thieves
Tardigrades, nearly microscopic animals that can survive the harshest of environments, including outer space, hold the record for the animal that has the most foreign DNA.
The Secret Behind the Power of Bacterial Sex
Migration between different communities of bacteria is the key to the type of gene transfer that can lead to the spread of traits such as antibiotic resistance, according to researchers at Oxford University.
Farming’s in Their DNA
Ancient genomes reveal natural selection in action.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos