Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

‘Liquid Biopsy’ Offers New Way to Track Lung Cancer

Published: Wednesday, June 04, 2014
Last Updated: Wednesday, June 04, 2014
Bookmark and Share
Scientists have shown how a lung cancer patient’s blood sample could be used to monitor and predict their response to treatment.

The recent study, published in the journal Nature Medicine, also offers a method to test new therapies in the lab and to better understand how tumours become resistant to drugs.

Small cell lung cancer (SCLC) is an aggressive disease with poor survival and new treatments are desperately needed. In many cases the tumour is inoperable and biopsies are difficult to obtain, giving scientists few samples with which to study the disease.

Now research carried out at Cancer Research UK’s Manchester Institute, based at The University of Manchester – part of the Manchester Cancer Research Centre – has looked at the potential of using circulating tumour cells (CTCs) – cells that have broken off from the tumour and are circulating in the blood – to investigate a patient’s disease in a minimally invasive manner. 

The researchers, working closely with lung specialist and Medical Oncologist Dr Fiona Blackhall at The Christie NHS Foundation Trust, found that patients with SCLC had many more CTCs in a small sample of their blood than patients with other types of cancer. Importantly, the number of CTCs for each patient was related to their survival – patients with fewer CTCs in their blood lived longer.

Professor Caroline Dive, who led the study, said: “Access to sufficient tumour tissue is a major barrier to us fully understanding the biology of SCLC. This liquid biopsy is straightforward and not invasive so can be easily repeated and will allow us to study the genetics of each lung cancer patient’s individual tumour. It also means that we may have a feasible way of monitoring patient response to therapy, hopefully allowing us to personalise and tailor individual treatment plans to each patient.”

In addition, the team were able to use these CTCs to grow tumour models in mice, which they termed CTC-derived explants (CDXs). When they treated these mice with the same chemotherapy drugs as the SCLC patients they showed that the CDXs responded in the same way as each donor patient.

“We can use these models to help us understand why so many SCLC patients acquire resistance to chemotherapy and to search for and test potential new targeted treatments,” added Professor Dive.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Blood Test Could Predict Best Treatment for Lung Cancer
Researchers at The Manchester University have isolated tumour cells that had broken away from the main cancer - known as CTCs - from the blood of 31 patients with this aggressive form of the disease.
Tuesday, November 22, 2016
New Discovery Sheds Light on Disease Risk
Gaps between genes interact to influence the risk of acquiring disease.
Tuesday, December 01, 2015
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Thursday, October 08, 2015
New Leukemia Gene Stops Blood Cells ‘Growing Up’
University of Manchester scientists have identified a gene – FOXC1 – that, if switched on, causes more aggressive cancer in a fifth of acute myeloid leukaemia (AML) patients, according to a Cancer Research UK study.
Wednesday, September 16, 2015
Gene Variants Show Potential In Predicting Rheumatoid Arthritis Disease Outcomes
Arthritis Research UK-funded scientists at The University of Manchester have identified a new way in which genotyping can be used to predict disease outcomes among sufferers of rheumatoid arthritis.
Thursday, April 30, 2015
Potential For Prediction Of Progression For Early Form Of Breast Cancer
Scientists in Manchester have identified a way to potentially predict which patients with an early form of breast cancer will experience disease progression.
Friday, April 17, 2015
Current Detection of Gene Mutations Misses People At High Risk Of Cancer
Research on the BRCA gene mutation in the Jewish population shows that the current process of identifying people misses half the people who have the mutation and are at risk of developing cancer.
Tuesday, December 02, 2014
New Insight into Drug Resistance in Metastatic Melanoma
A study by scientists in Manchester has shown how melanoma drugs can cause the cancer to progress once a patient has stopped responding to treatment.
Wednesday, June 04, 2014
Study Maps Human Metabolism in Health and Disease
Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual’s genetic make-up and their lifestyle.
Monday, March 04, 2013
Yeast Unravels Effects of Chemotherapy Drugs
Researchers identify new biological processes involved in the cellular response to N-BPs, opening up opportunities for the development of new anticancer drugs.
Friday, September 11, 2009
New Strategy in Fight against Cancer
Scientists have identified a new strategy in the fight against cancer, having found a mechanism for switching off a chemical signal that is intimately linked to progression of the disease.
Monday, September 22, 2008
Gene may Hold Key to Future Cancer Hope
The University of Manchester research has identified a key gene that appears to play a critical role in the normal process of cell division.
Tuesday, October 09, 2007
£2million Dwarfism Study Launched
An international team of researchers have been awarded more than £2million to study the genetic causes of dwarfism in a bid to develop future treatments.
Friday, June 01, 2007
Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Secret Phenotypes: Disease Devils in Invisible Details
Algorithmic deep phenotyping exposes masses of hidden traits and possible subtle genetic connections relevant to unseen influences on disease.
Cracking the Code of a Deadly Virus
Researchers have exploited weaknesses in VEEV's genetic code, creating a far less deadly variant.
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
Repurposing Genes for Brain Development
Mammalian bone gene may be repurposed to promote cognition in humans.
Enhancing CRISPR to Explore Further
Researchers have developed sOPTiKO, a more efficient and controllable CRISPR genome editing platform.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!