Corporate Banner
Satellite Banner
Genomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Aging Contributes to Rapid Rates of Genomic Change

Published: Thursday, June 26, 2014
Last Updated: Thursday, June 26, 2014
Bookmark and Share
Signaling challenges for personalized medicine.

Exploiting individual genomes for personalized medicine may be more complicated than medical scientists have suspected, researchers at Virginia Bioinformatics Institute have discovered.

In a paper published in June in the journal Aging, scientists from the institute's Medical Informatics and Systems Division found that spontaneous mutations occur in our bodies constantly, but the rate of change differed dramatically among various people.

The study has implications for personalized medicine, which will make use of genomic information to predict future diseases and treatments. With genomes continually shifting over time, the monitoring of genomic health will require more frequent measurement of patients' genomes.

"We have long known that there were mutations acquired in cancerous tumors, but this study confirms that our genome is constantly changing even in healthy tissues," said Harold "Skip" Garner, a professor of biological sciences and computer science at Virginia Tech and a professor of medicine at the Virginia Tech Carilion School of Medicine. "The implications on using genomic information for medicine and medical research in the future are tremendous. Things are not as simple as we once thought."

DNA in our cells changes from exposure to various environmental stressors. This can cause mutations in up to 13,000 genes that raise the risk of diabetes, kidney failure, cancer, rheumatoid arthritis, and Alzheimer's disease - conditions usually associated with aging.

The research may help scientists better understand how individuals tolerate environmental exposure and why some people seem to age faster or slower than others.

"We observed that certain portions of our genome age 100 times faster than others," Garner said. "Microsatellites, once considered 'junk DNA,' are known to be associated with many diseases. They change much faster than individual DNA bases (known as single nucleotide polymorphisms, or SNPs), so it is important that future studies look at this very dynamic part of the human genome."

The researchers used the latest DNA sequencing technology to study the genetic makeup of three individuals at different times in their lives, spanning nine to 16 years. One of the individuals had almost 10 times as many variations as the others, and was found to be at risk for many more potential diseases.

"We observed that the variation rate is specific to the individual and also varies even within an individual's genome," said Jasmin Bavarva, a geneticist at the institute and lead scientist on the project. "Understanding the dynamics of the genome is the key to the success of personalized genomics and this is a major step forward."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Big Genetics in BC: The American Society for Human Genetics 2016 Meeting
Themes at this year's meeting ranged from the verification, validation, and sharing of data, to the translation of laboratory findings into actionable clinical results.
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.
Unexpected Epigenetic Enzymes Role in Cancer
Researchers use epigenetics to identify the role of an enzyme family as regulators of genetic message interpretation in yeast.
Genetic Links to Brain Cancer Cell Growth
Researchers discover clues to tumour behaviour from genetic differences between brain cancer cells and normal tissue cells.
New Form of Autism Found
An international team of researchers have identified a new form of syndromic autism.
Tissue Damage Is Key for Cell Reprogramming
Researchers have shown tissue damage is important for cells to return to an embryonic state for cell reprogramming.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
Accelerating the Detection of Foodborne Bacterial Outbreaks
The speed of diagnosis of foodborne bacterial outbreaks could be improved by a new technique developed by researchers at the Georgia Institute of Technology.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!