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Repurposing Drugs for the Treatment of Multi-Drug Resistant Breast Cance
David Monaghan, Rachel Griffin, Amie Regan, Enda O’Connell, Howard Fearnhead

In this study, the Johns Hopkins Clinical Compound Library, containing approximately 1,500 FDA and foreign-approved clinical compounds, was used to screen a multi-drug resistant, triple negative breast cancer cell line for drug sensitivity.

Genome sequenicng and analysis of the emerging pathogen Corynebacterium ulcerans
Eva Trost, Andreas Tauch

Sequencing of two C. ulcerans isolates and identification of a noval putative virulence factor

Demethylation and Re-Expression of Tumor Suppressor Genes: A Novel Approach for Cancer Therapy
Genevieve Housman, Megan A. Mataga, Amrita Devalapalli, Sarah Heerboth, Leah R. Evans, Sibaji Sarkar

In this study, we demonstrated that a combination therapy using suboptimal doses of HDACi and calpeptin, an inhibitor of calpain, produced synergistic type growth inhibition and reduced cancer cell motility in cancer cells. We hypothesize that the re-expression of tumor suppressor genes by demethylation and other mechanisms sensitize the cells and allows for apoptotic death.

Development and NDA-Level Validation of a Real-Time PCR Procedure for Detection and Quantification of Residual E.coli DNA Contamination of Biopharmaceutical Products
Dan Papa, Pedro J. Morales and Michael D. Sadick

Escherichia coli (E. coli) has been commonly used for the production of biopharmaceuticals. Among the impurities that must be monitored in biopharmaceuticals is residual host-cell DNA (HCD). This study describes the development and subsequent NDA-level validation of a real time PCR procedure developed in response to a client’s need to improve the sensitivity of detection and quantification of residual E. coli HCD in their drug product.

Integrated In Silico Analysis of NGS Prostate Cancer Data via High-Resolution RNA-Seq Analysis
Sandeep Sanga , Antoaneta Vladimirova, Aubree Hoover

The goal: To get novel insights into the mechanisms of prostate adenocarcinoma by leveraging next generation sequencing (NGS) data, particularly human transcriptome data, through in silico data analysis and interpretation by Ingenuity’s IPA® software. CLC Genomics Workbench and CLC Genomics Server helped us assess short read RNA-Seq data.

DNA Methylation as a Marker of the Intra Uterine Environment
Carolyn Banister, Devin Koestler, Matthew A. Maccani, E. Andres Houseman, James F. Padbury and Carmen J. Marsit

The placenta functions not only as a conduit for nutrient and waste exchange between mother and fetus, but also as a regulator of the intrauterine environment. Recent work has identified changes in the expression of candidate genes, often through epigeneticalteration, which alter the placenta’s function and impact fetal growth.

Prognostic Factors for Refeeding Syndrome in Head and Neck Cancer Patients
James Hare, Rachel Skelly, Samit Ghosh, Terry Jones

Head and neck cancer sufferers are inherently at risk of refeeding syndrome, which had a prevalence of 9.5% in our series. Our results suggest that site of tumour (but not tumour or nodal staging) is a prognostic indicator for developing refeeding syndrome.

SuperNatural: A Database of Available Natural Compounds
Melanie Füllbeck, Mathias Dunkel and Robert Preissner

The majority of marketed drugs are natural compounds or derivatives thereof. The compounds availability is often unclear. Therefore we have compiled a database of ~50,000 natural compounds. Starting point for in silico screenings are about 2,500 well-known, classified natural compounds or imported molecules. Possible medical applications can be detected and about three million conformers computed to account for the flexibility during usage of the 3D-superposition algorithm.

Nucleic Acid Reagents and Experimental Results in the NCBI Probe Database
Svetlana Iazvovskaia, Ilene Karsch Mizrachi, Kirill Rotmistrovsky, and Savani Tatake

Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million probes of 65 types including gene silencing agents, in situ hybridization probes, and probes for variation analysis and genome mapping. Presently, ProbeDB is the largest and most extensive database of this type available in public domain.

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Showing Results 51 - 60 of 204
Scientific News
Gene Linked to Excess Male Hormones in Female Infertility Disorder
Discovery by NIH-supported researchers may lead to diagnostic test, treatment.
Unexpected Protein Partnership has Implications for Cancer Treatment
Scientists have identified a macrophage that works together in response to cancer drugs to increase inflammation in a way that may alter tumor growth.
Targeting Cancer with a Triple Threat
MIT chemists design nanoparticles that can deliver three cancer drugs at a time.
Breakthrough Profiling Technology to Improve Cancer Treatment on a Personalized Basis
New research paper published in the peer reviewed journal PLOS ONE.
Blocking DNA Repair Mechanisms Could Improve Brain Cancer Therapy
The findings were published April 7 in Nature Communications.
Study Identifies Growth Factor Receptors That May Prompt the Spread of Lung Cancer
Preventing lung cancers from metastasizing to other parts of the body could provide benefit for patients against the leading cause of cancer death.
Cancer’s Thirst For Copper Can Be Targeted
Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer.
An Integrated Approach to Clinical Genetics Research
OGT’s new whitepaper explores the next stage of molecular testing.
Improvement to Radiation Therapy for Deadly Brain Cancer
UT Southwestern Medical Center researchers have demonstrated in both cancer cell lines and in mice that blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas.
Obesity Primes the Colon for Cancer, According to NIH Study
The study appeared online April 1 in the journal Cell Metabolism.
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