Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
Become a Member | Sign in
Home>News>This Article

Definiens Expands Functionality of its Leading Solution for Quantitative Digital Pathology

Published: Monday, October 22, 2012
Last Updated: Monday, October 22, 2012
Bookmark and Share
Definiens Tissue Studio now supports the detection of spot-like signals from in situ hybridization assays.

Definiens® has announced that Definiens Tissue Studio® 3.5 now supports the automated analysis of in situ hybridization assays, including SISH, CISH, FISH and dual-ISH.

The unique combination of flexibility and ease-of-use that characterizes Definiens Tissue Studio® significantly facilitates the detection of spot-like signals originating from gene probes (or any other stain with spot-like appearance) on a cell-by-cell basis.

Definiens Tissue Studio® supports the detection of gene probe signals in both brightfield and immunofluorescene imaging.

The novel functionality complements the robust detection of regions of interest and the comprehensive quantification of cellular parameters and biomarker expression profiles.

Definiens Tissue Studio® can be used to analyze images from any solid tissue with any stain, acquired by any scanner or microscope, and in any common file format.

With these technological advances, pathologists and researchers can adapt preconfigured solutions to their specific assays with just a few clicks in no more than 30 minutes.

Straightforward workflow, intuitive configuration, as well as flexibility and robustness, have established Definiens Tissue Studio as the leading image analysis solution for quantitative digital pathology.

Definiens Tissue Studio opens new dimensions in quantification by significantly reducing study times in translational research, preclinical safety, tissue-based biomarker development and clinical trials around the world.

The new version includes a range of improvements that make it easier to use and more powerful than ever.

“Definiens has developed significant experience in the analysis of in situ hybridization assays in recent years,” said Thomas Heydler, CEO of Definiens.

Heydler continued, “In Definiens Tissue Studio® 3.5, we now make this available to our customers in a very easy-to-use workflow that supports virtually any type of 2D ISH assay. This further strengthens Definiens Tissue Studio’s position as the most comprehensive software package for quantitative digital pathology.”

With just a single configuration, Definiens Tissue Studio® automates the detection of regions of interest and has the capacity to distinguish individual cells and subcellular structures even in heterogeneous tissues samples.

The software provides quantitative readouts on morphological characteristics and molecular expression profiles of nuclear, cytoplasmic and membrane biomarkers.

In addition, Definiens Tissue Studio® supports robust detection of vessels for automated angiogenesis assays as well as extensive multiplexing for the quantification of numerous parameters from the same tissue sample in immunofluorescence assays.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Definiens Image Analysis Technology Improves Accuracy in Scoring Her2/neu in Breast Cancer Biopsies
New multi-dimensional image analysis platform aids diagnosis and treatment of breast cancer.
Wednesday, June 03, 2009
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
NIH Supports New Studies to Find Alzheimer’s Biomarkers in Down Syndrome
Initiative will track dementia onset, progress in Down syndrome volunteers.
University of Edinburgh, Selcia Achieve Key Milestones in Drug Development Program
Scientists from the University of Edinburgh, working with Selcia, have successfully passed the 20-month milestone targets of a 30-month Wellcome Trust SDDi £2.5 million project to design novel treatments for sleeping sickness.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Potential Persistent Tuberculosis Treatment
Researchers have discovered several first-in-class compounds that target hidden TB infections by attacking a critical process the bacteria use to survive in the hostile environment of the lungs.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
The Do’s and Don’ts of SPR Experiments
Surface Plasmon Resonance (SPR) is a technique that is becoming more widely used, particularly by anyone who wants to obtain accurate on (association) and off (dissociation) rates for biomolecular binding.
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos