Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Biomarker Discovery Center Receives Grant to Develop Diagnostic Blood Test

Published: Thursday, January 31, 2013
Last Updated: Thursday, January 31, 2013
Bookmark and Share
The $799,800 grant from the Osteopathic Heritage Foundation to develop is for a blood test that can diagnose mild cognitive impairment (MCI) caused by early-stage Alzheimer's disease.

MCI affects nearly one in every five adults older than 65, causing memory and language problems beyond those associated with normal aging. Individuals with MCI often exhibit early symptoms of dementia, and approximately 60 percent of all MCI cases are believed to be early-stage Alzheimer’s disease.

The grant from the Osteopathic Heritage Foundation will help expand earlier research conducted by Robert Nagele, PhD, the director of the Biomarker Discovery Center. Dr. Nagele’s published research includes recent findings that identify specific autoantibody biomarkers in the blood that can potentially be used to diagnose early stages of Alzheimer’s and Parkinson’s diseases.

“Using our novel biomarker discovery strategy, we have shown that it is possible to use a single drop of blood to diagnose Alzheimer’s and Parkinson’s with greater than 95 percent accuracy,” said Nagele. “This same approach should also allow us to identify a small number of biomarkers that can also accurately diagnose MCI caused by early-stage Alzheimer’s disease.”

The funded project will pursue three specific goals: identify a small number of autoantibody biomarkers that can accurately (90 percent or higher) diagnose MCI cases caused by early stage Alzheimer’s disease; verify the accuracy rate with a larger scale study; and construct and test a diagnostic kit that is maximally accurate for the broadest possible MCI patient population. If successful, the study will then take the steps needed for final Food and Drug Administration approval of the test.

Current approaches to MCI diagnosis rely on physical, neurological and psychiatric examinations, laboratory tests, and a thorough review of the patient’s medications and medical history. Recently, great attention has been given to using neuroimaging technologies to detect structural changes in the brain before symptoms appear. However, these approaches require expensive equipment and technology and can require hospital visits, the injection of radioactive compounds and the availability of radiologists with advanced training in these techniques.

“A relatively non-invasive test such as ours would allow for early detection of Alzheimer’s-driven MCI, which could lead to beneficial lifestyle changes and improved quality of life, and allow for patients and their families to plan for the future,” Nagele said. “It will also enable physicians to distinguish Alzheimer’s-driven MCI from that caused by other treatable conditions, such as drug reactions, depression or changes to the brain’s supply of blood or oxygen.”

While current treatments for Alzheimer’s cannot stop the progression of the disease, several medications are capable of significantly enhancing brain performance and alleviating symptoms. A number of promising drugs are also currently under development and in clinical trials for the treatment of early Alzheimer’s disease. An easy-to-administer blood test for MCI would give pharmaceutical companies a way to identify patients for clinical trials who are at a very early stage of their disease and give researchers a nearly immediate way to monitor the effectiveness of medications under examination.

The UMDNJ-School of Osteopathic Medicine, the New Jersey Health Foundation, and Durin Technologies, Inc., a biotechnology company with expertise in protein microarray technology, will provide additional support and in-kind contributions of staff, equipment and supplies directly related to this study.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Penn State, TB Alliance, and GSK Partner To Discover New Treatments For TB
A new collaboration between TB Alliance, GSK, and scientists in the Eberly College of Science seeks to find new small molecules that can be used to create antibiotics in the fight against tuberculosis (TB).
Molecular Map Provides Clues To Zinc-Related Diseases
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Platelets are the Pathfinders for Leukocyte Extravasation During Inflammation
Findings from the study could help in the prevention and treatment of inflammatory pathologies.
Genetic Research Can Significantly Improve Drug Development
With drug development costs topping $1.2bn (£850 million) to get a single treatment to the point it can be sold and used in the clinic, could genetic analysis save hundreds of millions of dollars?
New Method Opens Door to Development of Many New Medicines
Findings from TSRI reveal human proteins are better drug targets than previously thought.
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Blood Test That Detects Early Alzheimer’s Disease
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease – referred to as the mild cognitive impairment (MCI) stage – with unparalleled accuracy.
A New Approach to Chemical Synthesis
Communesins, originally found in fungus, could hold potential as cancer drugs.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!