Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Why Does Smallpox Vaccine Shield Some, Not Others? It's in the Genes

Published: Tuesday, April 23, 2013
Last Updated: Tuesday, April 23, 2013
Bookmark and Share
How well people are protected by the smallpox vaccine depends on more than the quality of the vaccination: individual genes can alter their response, Mayo Clinic research shows.

The findings, gathered using sophisticated genomic screening, appear in today's online issue of the journal Genes and Immunity.

"We were looking into the intercellular reactions that occur when vaccinated and unvaccinated persons are exposed to and infected with smallpox virus. We were able to use blood samples taken directly from vaccinated patients," says senior author Gregory Poland, M.D., director of the Mayo Clinic Vaccine Research Group. "We could see what would happen based on exposing a mixed-cell peripheral blood cell population to the vaccinia virus."

While worldwide vaccination is believed to have eradicated smallpox, the highly contagious and sometimes fatal illness remains a bioterrorism concern.

Researchers studied 44 participants from Mayo Clinic and the Naval Health Research Center who had received the smallpox vaccine in the previous 48 months. Two samples were prepared from each of the 44, one uninfected and one that was infected with vaccinia, a smallpox-like virus. RNA (ribonucleic acid, molecules that represent the DNA makeup) from the samples was then tested in the high-speed sequencing facilities at Mayo Clinic's Center for Individualized Medicine. Genetic differences were found between people with robust protective antibodies and those with lower immunity from smallpox.

Dr. Poland says this individualized medicine approach and its findings offer researchers new targets for developing tests to determine if a person should receive a specific vaccine, but also an opportunity to develop new vaccines to benefit non-responders.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Mayo Clinic Forms Joint Venture with Cancer Genetics
OncoSpire Genomics will seek to discover and commercialize biomarkers for multiple cancer types.
Thursday, May 23, 2013
Mayo Clinic Receives Funding for Gut Function Biomarker Research
The program aims to identify and validate biomarkers that can assess gut function and guide new ways to improve the health and development of children in the developing world.
Friday, December 28, 2012
Mitochondrial Dysfunction Present Early in Alzheimer’s, Before Memory Loss
Using genetic mouse models, Mayo Clinic researchers have discovered that mitochondria in the brain are dysfunctional early in the disease.
Thursday, March 01, 2012
Mayo Clinic to Collaborate with Indian Science Leaders
The collaboration will cover areas such as drug, device and biomarker studies relating to heart disease, chemical biology, applied genomics and innovations in metabolomics.
Wednesday, October 19, 2011
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Peer Reviewed Study Demonstrates Mass Spec Technique
The peer reviewed study demonstrates MS workflow, TMTCalibrator workflow, which dramatically enhances detection of key early stage Alzheimer’s biomarkers.
Small Molecules Lead to Big Change in Reaction Outcomes
Scientists have changed the behaviour of a group of molecules involved in carbon-oxygen bond synthesis.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
Sanger Institute, St Jude Data-Sharing Agreement
Childhood cancer targeted by Sanger Institute and St Jude Children’s Research Hospital exchanges of cancer data
Over Two-Thirds of Cervical Cancer Deaths Prevented
Cervical screening prevents 70% of cervical cancer deaths and if all eligible women regularly attended screening this would rise to 83%.
Space Research Fighting Cancer
JPL and National Cancer Institute renew Big Data partnership that 'learns' data similarities.
Uncovering the Genetics Behind High Blood Pressure
Results suggest a role for blood vessels themselves in controlling blood pressure.
Detecting Bacterial Infections in Newborns
Researchers tested an alternative way to diagnose bacterial infections in infants—by analyzing RNA biosignatures from a small blood sample.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!