Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

A New European Consortium to Boost our Understanding of IBD

Published: Thursday, May 23, 2013
Last Updated: Thursday, May 23, 2013
Bookmark and Share
A multi-modal integrated biomarker study Consortium to increase diagnostic precision in detection of the diseases.

The Inflammatory Bowel Disease Characterization by a multi-modal integrated biomarker study (IBD-Character) Consortium is a collaborative effort to advance our understanding of the inflammatory bowel diseases Ulcerative Colitis and Crohn's Disease and to increase diagnostic precision in detection of the diseases in their early manifestation.

The consortium associates 10 European partners from both academia and industry. It starts with a € 6M grant thanks to the European Commission´s 7th Framework Program (FP7).

The project will generate the largest collection of samples so far assembled from treatment naïve patients recently diagnosed with inflammatory bowel disease.

DNA methylation and RNA transcription status, protein markers, gut microbial content, patient genotype for known susceptibility loci and classical clinical data will be extensively analyzed for the characterization of the cohort in order to create a molecular snapshot of IBD in its early manifestation.

This massive molecular profiling will be used to yield a list of biomarkers indicative for onset of the disease.

The participating Small and Medium sized Enterprises (SMEs) will develop assays capable of analyzing panels of several hundred relevant protein markers as well as methods for rapid profiling of gut microbial content relevant for IBD.

The proposed biomarkers will form a solid ground for development of improved diagnostic assays and be a rich source to mine for novel therapeutic targets.

"We are pleased to have gathered such a strong combination of clinicians, clinical researchers, basic researchers and innovative SME:s into one focused project," said Dr. Mats Gullberg, project coordinator for IBD-Character and Chief Technology Officer at Olink Bioscience.

Dr. Gullberg continued, "The project will advance our understanding of IBD as well as generate proprietary products by the participating SMEs. The project will provide the most complete molecular characterization of samples from patients with IBD and also progress the field of analysis of large data sets containing different types of molecular markers from large sets of individuals."

Based on the findings within the IBD-Character project, results are expected to improve many aspects of patient care, including the development of new personalized medical strategies and treatments.

Consortium members

The project will be co-ordinated by Olink Bioscience (Sweden) with partners coming from several European countries including the United Kingdom, Sweden, Belgium, Spain and Norway.

The IBD-Character Consortium unites researchers from three SME:s, one research institute, five Universities and one public, non-profit organization.

IBD-Character is a four year project running from the 1st of December 2012 until the 30th of November 2016 and is funded by the 7th Framework Program of the European Commission. In addition to the research activities, IBD-Character will be organizing meetings, workshops and will be present at a number of international conferences.

Members of the consortium:
• Olink Bioscience (Coordinator, SME), Mats Gullberg, SE
• Diagenode (SME), Hélène Pendeville, BE
• Genetic Analsysis (SME), Heidi Vebø, NO
• Instituto Aragonés de Ciencias de la Salud/IIS Aragón, Fernando Gomollón, ES
• Linköpings Universitet, Johan Söderholm, Åsa Keita SE
• The University of Edinburgh, Jack Satsangi, UK
• Örebro University Hospital, Jonas Halfvarson, SE
• Centro Nacional de Análisis Genómico, Ivo Gut, Monica Bayés, ES
• Karolinska Institutet, Mauro D’Amato, SE
• Universitetet I Oslo, Morten H. Vatn, Bettina Kulle Andreassen, NO


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Friday, May 17, 2013
Scientific News
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Cytoskeleton Crew
Findings confirm sugar's role in helping cancers survive by changing cellular architecture.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Valvena, GSK Sign New R&D Collaboration
Valneva to supply process development services for EB66® -based Influenza vaccines.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!