Corporate Banner
Satellite Banner
Biomolecular Screening
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

How Disease-Related Proteins Work; a "Truly Momentous" Discovery

Published: Tuesday, July 09, 2013
Last Updated: Tuesday, July 09, 2013
Bookmark and Share
Researchers are helping demystify an important class of proteins associated with disease.

Professor Igor Stagljar of the Faculty of Medicine’s Donnelly Centre for Cellular and Biomolecular Research, and his team have developed the first road map for an important group of proteins known as ATP-binding cassette (ABC) transporter proteins.

“Our discovery shows how ABC transporter proteins affect cancer and other diseases, and this knowledge can help us develop better, more targeted drugs," said Stagljar. "This is truly momentous."

The ABC transporter proteins are crucial components of every cell, and are also involved in tumor resistance —when cancerous tumours become resistant to drug therapy.

Scientists have struggled to understand how these proteins work and communicate with other proteins but Stagljar and his team, including first author Dr. Jamie Snider, have solved the mystery by using something called Membrane Yeast Two-Hybrid (‘MYTH’) technology to see how these transporter proteins interact with other vital components in the cell.

“Cell systems are complex and we need to have a solid grasp of how the individual pieces fit together in order to understand why certain diseases occur and how to best treat them,” says Stagljar, who is also cross-appointed to the Departments of Biochemistry and Molecular Genetics.

ABC transporter proteins act as cellular gatekeepers by retaining nutrients and expelling toxins from the cell. If these proteins are not working properly, it can cause a number of diseases including: cystic fibrosis; age-related macular degeneration; Tangier disease; and Dubin-Johnson syndrome.

ABC proteins can also cause cancer cells to reject chemotherapy drugs which makes treatment less effective.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Cancer-causing Protein “Turned Off”
Clinical trials on the horizon for experimental cancer drug.
Friday, December 04, 2015
Stem Cells: How to Predict Their Fate
Technique has potential for regenerative medicine and drug development.
Thursday, October 31, 2013
University of Toronto Breakthrough Allows Fast, Reliable Identification of Pathogens
Researchers have created an electronic chip that can analyze blood and other clinical samples for infectious bacteria with record-breaking speed.
Friday, June 21, 2013
Scientific News
Breast Cancer Drug Hope
A drug for breast cancer that is more effective than existing medicines may be a step closer thanks to new research.
A New Platform for Discovering Antibiotics
Harvard chemists hope to shorten time, difficulty in measuring their effectiveness, potential.
The Need for Speed
Evaluating MALDI-TOF as a high-throughput screening technology for the pharmaceutical industry.
Antarctic Sponge Extract Kills MRSA
New findings may provide opportunity for developing new drugs to fight dangerous bacteria currently highly resistant to treatment.
US-India Collab Finds Molecular Signatures of Severe Malaria
Study may be a significant advancement in understanding the causes of severe malaria.
Novel Way to Prevent Deadly Bacterial Infections
Monash scientists may have found a way to stop deadly bacteria from infecting patients. The discovery could lead to a whole new way of treating antibiotic-resistant “superbugs”
Gene Expression Controls Revealed
Researchers have modelled every atom in a key part of the process for switching on genes, revealing a whole new area for potential drug targets.
An Old-New Weapon Against Emerging Chikungunya Virus
Researchers utilize existing drugs to interfere with host factors required for replication of Chikungunya virus.
Using Gene-editing Technology for Faster, Cheaper Antiviral Drug Development
UCLA scientists are working to develop special screening libraries based on a gene-editing technology called CRISPR.
Can Gender Play A Role In Determining Cancer Treatment Choices?
MD Anderson study reveals “sex-biased” gene signatures in review of 13 cancer types.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!